Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

(2018) Ye Zhao et al.   Mucosal Immunology

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2016) Aiden Haghikia et al.   IMMUNITY

Microbiota-specific Th17 Cells

(2016) Wei Wu et al.   INFLAMMATORY BOWEL DISEASES

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology

(2016) Marcela Montes de Oca et al.   PLoS Pathogens

TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression

(2015) Hou-Pu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

(2015) Yonghao Cao et al.   Science Translational Medicine

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Comprehensive Intestinal T Helper Cell Profiling Reveals Specific Accumulation of IFN-γ+IL-17+Coproducing CD4+ T Cells in Active Inflammatory Bowel Disease

(2014) Anna-Maria Globig et al.   INFLAMMATORY BOWEL DISEASES

Role of Blimp-1 in programing Th effector cells into IL-10 producers

(2014) Christian Neumann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1

(2014) Christina Heinemann et al.   Nature Communications

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

(2014) Chang H. Kim et al.   Immune Network

Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

(2013) Vadivel Ganapathy et al.   CURRENT OPINION IN PHARMACOLOGY

Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies

(2013) David Ellinghaus et al.   GASTROENTEROLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells

(2012) M.-H. Lin et al.   DIABETOLOGIA

Defective IL10 Signaling Defining a Subgroup of Patients With Inflammatory Bowel Disease

(2011) Bernadette Begue et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

(2011) Ting Feng et al.   GASTROENTEROLOGY

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

(2011) Samuel Huber et al.   IMMUNITY

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

(2011) Laurence Macia et al.   IMMUNOLOGICAL REVIEWS

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

(2011) Martina Lukasova et al.   JOURNAL OF CLINICAL INVESTIGATION

Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production

(2011) T. Feng et al.   JOURNAL OF IMMUNOLOGY

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

(2011) Erika Cretney et al.   NATURE IMMUNOLOGY

Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission

(2010) Henrike M. Hamer et al.   CLINICAL NUTRITION

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

(2009) Hyokjoon Kwon et al.   IMMUNITY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

(2009) Soumya Raychaudhuri et al.   NATURE GENETICS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

(2009) Y. Cong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

(2008) Andre Franke et al.   NATURE GENETICS