Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2016) Aiden Haghikia et al.   IMMUNITY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.

(2016) Allison Agus et al.   Scientific Reports

Chemical communication in the gut: Effects of microbiota-generated metabolites on gastrointestinal bacterial pathogens

(2015) Stefanie L. Vogt et al.   ANAEROBE

Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions

(2015) Ashish Gurav et al.   BIOCHEMICAL JOURNAL

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain

(2015) Yangzom D. Bhutia et al.   IMMUNITY

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

(2015) Angélica T. Vieira et al.   Arthritis & Rheumatology

The effect of short-chain fatty acids on human monocyte-derived dendritic cells

(2015) Claudia Nastasi et al.   Scientific Reports

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

(2014) Nicole Reichardt et al.   ISME Journal

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

(2014) Hui Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

A decrease of the butyrate-producing speciesRoseburia hominisandFaecalibacterium prausnitziidefines dysbiosis in patients with ulcerative colitis

(2013) Kathleen Machiels et al.   GUT

G Protein-Coupled Receptor 43 Moderates Gut Inflammation Through Cytokine Regulation from Mononuclear Cells

(2013) Ryuta Masui et al.   INFLAMMATORY BOWEL DISEASES

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Butyricicoccus pullicaecorumin inflammatory bowel disease

(2012) Venessa Eeckhaut et al.   GUT

Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon

(2012) Xiaolei Ze et al.   ISME Journal

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

(2011) Laurence Macia et al.   IMMUNOLOGICAL REVIEWS

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

(2011) Martina Lukasova et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer

(2010) Yong Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary Cycloinulooligosaccharides Enhance Intestinal Immunoglobulin A Production in Mice

(2009) Tomomi ISHIKAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites

(2009) Marco A. R. Vinolo et al.   CLINICAL SCIENCE

Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene

(2009) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation

(2009) C. Sina et al.   JOURNAL OF IMMUNOLOGY

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation

(2008) Stephen W. Ragsdale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Effects of short chain fatty acids on effector mechanisms of neutrophils

(2008) Marco A. R. Vinolo et al.   CELL BIOCHEMISTRY AND FUNCTION