期刊
LUPUS
卷 27, 期 6, 页码 930-938出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203317751860
关键词
Systemic lupus erythematosus; polyamine; biomarker; disease activity
类别
资金
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute - Ministry of Health & Welfare, Republic of Korea [HI16C0992]
- Priority Research Centers Program through the National Research Foundation of Korea - Ministry of Education, Science and Technology [2009-0093826]
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations and serologic markers. In this study, we analyzed nine polyamine (PA) profiles of plasma from patients with SLE and healthy controls (HCs), and the relationship between the PA profiles and disease activity. PA alterations in plasma of 44 patients with SLE and fever were investigated using gas chromatography mass spectrometry (GC-MS) in selected ion monitoring mode using N-ethoxycarbonyl/N-pentafluoropropionyl derivatives, and compared with those of 43HCs. Patients with SLE and HCs showed differences in five of nine PA profiles. Among five changed PA levels, four PAs, namely N-1-acetylcadaverine, spermidine, N-1-acetylspermidine, and spermine, were dramatically decreased. However, the level of cadaverine was increased in patients with SLE. In the partial correlation with PA profiles and disease activity markers of SLE, several disease activity markers and nutritional markers were correlated with cadaverine, spermidine, and N-8-acetylspermidine. Thus, our results provide a comprehensive understanding of the relationship between PA metabolomics and disease activity markers in patients with SLE.
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