The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
出版年份 2020 全文链接
标题
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
作者
关键词
Osteoarthritis (OA), Cartilage, Chondrocyte, Metabolism, Hypoxia, Glycolysis, Oxidative phosphorylation, Metabolic dysfunction, Therapeutic
出版物
AGEING RESEARCH REVIEWS
Volume 66, Issue -, Pages 101249
出版商
Elsevier BV
发表日期
2020-12-29
DOI
10.1016/j.arr.2020.101249
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Magnolol Alleviates IL-1β-Induced Dysfunction of Chondrocytes Through Repression of SIRT1/AMPK/PGC-1α Signaling Pathway
- (2020) Zili Liu et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Mitochondrial TCA cycle metabolites control physiology and disease
- (2020) Inmaculada Martínez-Reyes et al. Nature Communications
- Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis
- (2020) Jiapeng Bao et al. Aging-US
- Metformin limits osteoarthritis development and progression through activation of AMPK signalling
- (2020) Jun Li et al. ANNALS OF THE RHEUMATIC DISEASES
- Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling
- (2020) Keita Okada et al. Scientific Reports
- Ex Vivo Equine Cartilage Explant Osteoarthritis Model: A Metabolomics and Proteomics Study
- (2020) James R. Anderson et al. JOURNAL OF PROTEOME RESEARCH
- Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy
- (2020) Sunli Hu et al. Cell Death & Disease
- LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
- (2020) Manoj Arra et al. Nature Communications
- Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis
- (2020) Yan Zhou et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue
- (2020) Yang Liu et al. CELL
- Critical role for arginase II in osteoarthritis pathogenesis
- (2019) Wan-Su Choi et al. ANNALS OF THE RHEUMATIC DISEASES
- HIF-1α metabolically controls collagen synthesis and modification in chondrocytes
- (2019) Steve Stegen et al. NATURE
- The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis
- (2019) Wan-Su Choi et al. NATURE
- Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad
- (2019) Anne-Mari Mustonen et al. Lipids in Health and Disease
- Effects of AURKA-mediated degradation of SOD2 on mitochondrial dysfunction and cartilage homeostasis in osteoarthritis
- (2019) Cheng Yang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model
- (2019) Kai Feng et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Silk fibroin nanoparticles for celecoxib and curcumin delivery: ROS-scavenging and anti-inflammatory activities in an in vitro model of osteoarthritis
- (2019) Barbara Crivelli et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Osteoarthritis
- (2019) David J Hunter et al. LANCET
- A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
- (2019) Yuanyuan Shi et al. Nature Communications
- Application of Metabolomics to Osteoarthritis: from Basic Science to the Clinical Approach
- (2019) Salah Ali A. Showiheen et al. Current Rheumatology Reports
- Cardiovascular profile in osteoarthritis: a meta-analysis of cardiovascular events and risk factors
- (2019) Sylvain Mathieu et al. JOINT BONE SPINE
- The association of plasma fatty acids levels with hand and knee osteoarthritis
- (2019) M. Loef et al. OSTEOARTHRITIS AND CARTILAGE
- Activation of The Phosphatidylcholine to Lysophosphatidylcholine Pathway Is Associated with Osteoarthritis Knee Cartilage Volume Loss Over Time
- (2019) Guangju Zhai et al. Scientific Reports
- MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling
- (2019) Chen Cai et al. Aging-US
- Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation
- (2019) Azuma Kosai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles
- (2019) P. Akhbari et al. OSTEOARTHRITIS AND CARTILAGE
- Pyruvate kinase M2: A simple molecule with complex functions
- (2019) Mohammed Alquraishi et al. FREE RADICAL BIOLOGY AND MEDICINE
- Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization
- (2019) O.R. Mahon et al. OSTEOARTHRITIS AND CARTILAGE
- In vivo assessment of extracellular pH of joint tissues using acidoCEST-UTE MRI
- (2019) Rachel A. High et al. Quantitative Imaging in Medicine and Surgery
- Zinc protects chondrocytes from monosodium iodoacetate-induced damage by enhancing ATP and mitophagy
- (2019) Li-Wen Huang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Active Vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK/mTOR signaling pathway
- (2019) Chunyu Kong et al. Biochemistry and Cell Biology
- New aspects of amino acid metabolism in cancer
- (2019) Lisa Vettore et al. BRITISH JOURNAL OF CANCER
- Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model
- (2019) Shang Piao et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Mechanisms and regulation of cholesterol homeostasis
- (2019) Jie Luo et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure
- (2019) Li Qing-xian et al. PHARMACOLOGICAL RESEARCH
- Oral administration of N-acetyl cysteine prevents osteoarthritis development and progression in a rat model
- (2019) Yosuke Kaneko et al. Scientific Reports
- PKM2: A Potential Regulator of Rheumatoid Arthritis via Glycolytic and Non-Glycolytic Pathways
- (2019) Danyi Xu et al. Frontiers in Immunology
- Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis
- (2018) Marta Varela-Eirin et al. AGEING RESEARCH REVIEWS
- Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2
- (2018) Haiyan Zhang et al. ANNALS OF THE RHEUMATIC DISEASES
- Unraveling the Complex Interplay Between T Cell Metabolism and Function
- (2018) Ramon I. Klein Geltink et al. Annual Review of Immunology
- Advances in Hypoxia-Inducible Factor Biology
- (2018) Hani Choudhry et al. Cell Metabolism
- Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
- (2018) Graeme I. Lancaster et al. Cell Metabolism
- Reactive Oxygen Species in Metabolic and Inflammatory Signaling
- (2018) Steven J. Forrester et al. CIRCULATION RESEARCH
- Bioactive lipids in osteoarthritis
- (2018) Andreea Ioan-Facsinay et al. CURRENT OPINION IN RHEUMATOLOGY
- Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis
- (2018) Xiaobo Yang et al. DNA AND CELL BIOLOGY
- Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
- (2018) Nadee Nissanka et al. FEBS LETTERS
- Osteoarthritis as a disease of the cartilage pericellular matrix
- (2018) Farshid Guilak et al. MATRIX BIOLOGY
- Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes
- (2018) Francisco J. Blanco et al. Nature Reviews Rheumatology
- Altered N -methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes
- (2018) Maggie L. Kalev-Zylinska et al. OSTEOARTHRITIS AND CARTILAGE
- Activation of AMPK-SIRT3 Signaling is Chondroprotective by Preserving Mitochondrial DNA Integrity and Function
- (2018) Liang-Yu Chen et al. OSTEOARTHRITIS AND CARTILAGE
- Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 Signaling Pathway in Osteoarthritis Rats
- (2018) Luyao Wang et al. PHARMACOLOGY
- Presence of comorbidities and prognosis of clinical symptoms in knee and/or hip osteoarthritis: A systematic review and meta-analysis
- (2018) Patrick Calders et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation
- (2018) Thomas Karonitsch et al. Cell Reports
- Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis
- (2018) Cuicui Wang et al. Journal of Orthopaedic Translation
- Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis
- (2018) Marta F Bustamante et al. ANNALS OF THE RHEUMATIC DISEASES
- Physiological dynamic compression regulates central energy metabolism in primary human chondrocytes
- (2018) Daniel Salinas et al. Biomechanics and Modeling in Mechanobiology
- Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes
- (2018) Mohammad Y. Ansari et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Reactive oxygen species, aging and articular cartilage homeostasis
- (2018) Jesalyn A. Bolduc et al. FREE RADICAL BIOLOGY AND MEDICINE
- Fatty acids and osteoarthritis: different types, different effects
- (2018) Marieke Loef et al. JOINT BONE SPINE
- PI3K/Akt and caspase pathways mediate oxidative stress-induced chondrocyte apoptosis
- (2018) Dong Li et al. CELL STRESS & CHAPERONES
- Pro-inflammatory cytokines: The link between obesity and osteoarthritis
- (2018) Tiantian Wang et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans
- (2018) Bon San Koo et al. International Journal of Rheumatic Diseases
- Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis
- (2018) Yasutaka Murahashi et al. Scientific Reports
- Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures
- (2018) Bernhard Rieder et al. Scientific Reports
- Redox control of chondrocyte differentiation and chondrogenesis
- (2018) Yun Bai et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease
- (2018) E. Sandra Chocron et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- ROS-induced ROS release in plant and animal cells
- (2017) Sara I. Zandalinas et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cell Biology of the Mitochondrion
- (2017) Alexander M. van der Bliek et al. GENETICS
- Cholesterol metabolism in pathogenesis of osteoarthritis disease
- (2017) Saba Farnaghi et al. International Journal of Rheumatic Diseases
- Global and targeted metabolomics of synovial fluid discovers special osteoarthritis metabolites
- (2017) Kaidi Zheng et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- The Effect of Aging and Mechanical Loading on the Metabolism of Articular Cartilage
- (2017) Adam El Mongy Jørgensen et al. JOURNAL OF RHEUMATOLOGY
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- Osteoarthritis: In search of phenotypes
- (2017) Sita M. Bierma-Zeinstra et al. Nature Reviews Rheumatology
- The role of metabolism in the pathogenesis of osteoarthritis
- (2017) Ali Mobasheri et al. Nature Reviews Rheumatology
- Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study
- (2017) N. Frey et al. OSTEOARTHRITIS AND CARTILAGE
- Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans
- (2017) H.S. Jónasdóttir et al. OSTEOARTHRITIS AND CARTILAGE
- Cell Biology of the Mitochondrion
- (2017) Alexander M. van der Bliek et al. GENETICS
- Combining Targeted Metabolomic Data with a Model of Glucose Metabolism: Toward Progress in Chondrocyte Mechanotransduction
- (2017) Daniel Salinas et al. PLoS One
- Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease
- (2016) Aneesa Ansari et al. AGING CELL
- Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health
- (2016) Yusheng Li et al. AMINO ACIDS
- Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature
- (2016) A. Dell’Isola et al. BMC MUSCULOSKELETAL DISORDERS
- Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges
- (2016) Maryam Rahmati et al. BONE
- From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence
- (2016) Christopher D. Wiley et al. Cell Metabolism
- PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage
- (2016) Jining Qu et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis
- (2016) Houda Benabdoune et al. INFLAMMATION RESEARCH
- Advanced oxidation protein products induce catabolic effect through oxidant-dependent activation of NF-κ B pathway in human chondrocyte
- (2016) Wenbin Ye et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease
- (2016) Tsuyoshi Shirai et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis
- (2016) Ronald K. June et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Metabolomic analysis of human synovial fluid and plasma reveals that phosphatidylcholine metabolism is associated with both osteoarthritis and diabetes mellitus
- (2016) Weidong Zhang et al. Metabolomics
- Ageing and the pathogenesis of osteoarthritis
- (2016) Richard F. Loeser et al. Nature Reviews Rheumatology
- Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study
- (2016) R.F. Loeser et al. OSTEOARTHRITIS AND CARTILAGE
- Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients
- (2016) W. Zhang et al. OSTEOARTHRITIS AND CARTILAGE
- Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis
- (2016) Weidong Zhang et al. RHEUMATOLOGY
- Profile of Free Fatty Acids and Fractions of Phospholipids, Cholesterol Esters and Triglycerides in Serum of Obese Youth with and without Metabolic Syndrome
- (2016) Juliana Bermúdez-Cardona et al. Nutrients
- Osteoarthritis
- (2016) Johanne Martel-Pelletier et al. Nature Reviews Disease Primers
- Inflammaging: disturbed interplay between autophagy and inflammasomes
- (2016) Antero Salminen et al. Aging-US
- Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology
- (2015) Dimitrios Tsikas et al. AMINO ACIDS
- Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease
- (2015) Gráinne S. Gorman et al. ANNALS OF NEUROLOGY
- Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis
- (2015) Hilde Brouwers et al. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
- The contributions of respiration and glycolysis to extracellular acid production
- (2015) Shona A. Mookerjee et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- (2015) Beth Kelly et al. CELL RESEARCH
- Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis
- (2015) Qingmeng Zhang et al. DISEASE MARKERS
- Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
- (2015) Hyun Hwang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mechanotransduction in primary human osteoarthritic chondrocytes is mediated by metabolism of energy, lipids, and amino acids
- (2015) Donald L. Zignego et al. JOURNAL OF BIOMECHANICS
- Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis
- (2015) Beata Mickiewicz et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis
- (2015) Ali Mobasheri et al. MATURITAS
- Excitatory amino acid glutamate: role in peripheral nociceptive transduction and inflammation in experimental and clinical osteoarthritis
- (2015) Z.-H. Wen et al. OSTEOARTHRITIS AND CARTILAGE
- Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis
- (2015) V. Silverwood et al. OSTEOARTHRITIS AND CARTILAGE
- The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
- (2015) Charles N. Serhan et al. SEMINARS IN IMMUNOLOGY
- mTOR: A Potential Therapeutic Target in Osteoarthritis?
- (2015) Bandna Pal et al. Drugs in research & development
- Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes
- (2015) Hongming Miao et al. Scientific Reports
- A review on phospholipids and their main applications in drug delivery systems
- (2015) Jing Li et al. Asian Journal of Pharmaceutical Sciences
- Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration
- (2015) Masato Koike et al. Scientific Reports
- Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
- (2014) Yue Zhang et al. ANNALS OF THE RHEUMATIC DISEASES
- Candidate mediators of chondrocyte mechanotransduction via targeted and untargeted metabolomic measurements
- (2014) Aaron A. Jutila et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
- (2014) David Heras-Sandoval et al. CELLULAR SIGNALLING
- Advanced glycation end products-induced chondrocyte apoptosis through mitochondrial dysfunction in cultured rabbit chondrocyte
- (2014) Qingshan Yang et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
- (2014) Hezhi Fang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Signaling Pathways in Cartilage Repair
- (2014) Erminia Mariani et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis
- (2014) Beata Mickiewicz et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- mtDNA haplogroups and osteoarthritis in different geographic populations
- (2014) A. Soto-Hermida et al. MITOCHONDRION
- Pro-resolving lipid mediators are leads for resolution physiology
- (2014) Charles N. Serhan NATURE
- The individual and socioeconomic impact of osteoarthritis
- (2014) David J. Hunter et al. Nature Reviews Rheumatology
- Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis
- (2014) T. Weng et al. OSTEOARTHRITIS AND CARTILAGE
- Regulation of Human Trophoblast GLUT1 Glucose Transporter by Insulin-Like Growth Factor I (IGF-I)
- (2014) Marc U. Baumann et al. PLoS One
- Role of mtDNA Haplogroups in the Prevalence of Osteoarthritis in Different Geographic Populations: A Meta-Analysis
- (2014) Jin-Ming Shen et al. PLoS One
- Malalignment: a possible target for prevention of incident knee osteoarthritis in overweight and obese women
- (2014) J. Runhaar et al. RHEUMATOLOGY
- Enhancement of the synthesis of n-3 PUFAs infat-1transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice
- (2013) Min-jun Huang et al. ANNALS OF THE RHEUMATIC DISEASES
- Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice—a translational model for atherosclerosis
- (2013) L M Gierman et al. ANNALS OF THE RHEUMATIC DISEASES
- Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage
- (2013) Brendan L. Thoms et al. ARTHRITIS AND RHEUMATISM
- Citric Acid Cycle and Role of its Intermediates in Metabolism
- (2013) Muhammad Akram CELL BIOCHEMISTRY AND BIOPHYSICS
- Metabolism of inflammation limited by AMPK and pseudo-starvation
- (2013) Luke A. J. O'Neill et al. NATURE
- Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes
- (2013) Freyr Petursson et al. ARTHRITIS RESEARCH & THERAPY
- Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis
- (2013) Wouter de Munter et al. ARTHRITIS RESEARCH & THERAPY
- L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis
- (2013) Valerio Pascale et al. MEDICAL SCIENCE MONITOR
- Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes
- (2012) Carlos Vaamonde-García et al. ARTHRITIS AND RHEUMATISM
- Osteoarthritis of the knee and hip. Part I: aetiology and pathogenesis as a basis for pharmacotherapy
- (2012) Aleem Adatia et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes
- (2012) Trevor W. Oren et al. JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT
- Nitrite and nitric oxide metabolism in peripheral artery disease
- (2012) Jason D. Allen et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study
- (2012) K.R. Baker et al. OSTEOARTHRITIS AND CARTILAGE
- Characterization of nitrotyrosine as a biomarker for arthritis and joint injury
- (2012) T.P. Misko et al. OSTEOARTHRITIS AND CARTILAGE
- l-Carnitine enhances extracellular matrix synthesis in human primary chondrocytes
- (2012) Daniela Stoppoloni et al. RHEUMATOLOGY INTERNATIONAL
- Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator
- (2012) Ali Mobasheri Frontiers in Endocrinology
- Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
- (2011) Beatriz Caramés et al. ANNALS OF THE RHEUMATIC DISEASES
- Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice
- (2011) Je-Hwang Ryu et al. ARTHRITIS AND RHEUMATISM
- Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α
- (2011) Robert Terkeltaub et al. ARTHRITIS AND RHEUMATISM
- Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
- (2011) Richard F. Loeser et al. ARTHRITIS AND RHEUMATISM
- Dynamics of arachidonic acid mobilization by inflammatory cells
- (2011) Alma M. Astudillo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- FATTY ACIDS AS BIOCOMPOUNDS: THEIR ROLE IN HUMAN METABOLISM, HEALTH AND DISEASE - A REVIEW. PART 1: CLASSIFICATION, DIETARY SOURCES AND BIOLOGICAL FUNCTIONS
- (2011) Eva Tvrzicka et al. BIOMEDICAL PAPERS-OLOMOUC
- Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction
- (2011) J-H Ryu et al. CELL DEATH AND DIFFERENTIATION
- Inflammation in osteoarthritis
- (2011) Mary B. Goldring et al. CURRENT OPINION IN RHEUMATOLOGY
- Aging and osteoarthritis
- (2011) Richard F. Loeser CURRENT OPINION IN RHEUMATOLOGY
- C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes
- (2011) Makoto Hirata et al. HUMAN MOLECULAR GENETICS
- The role of mitochondria in osteoarthritis
- (2011) Francisco J. Blanco et al. Nature Reviews Rheumatology
- High-resolution magic angle spinning NMR spectroscopy of human osteoarthritic cartilage
- (2011) Keerthi Shet et al. NMR IN BIOMEDICINE
- The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review
- (2011) D. Pereira et al. OSTEOARTHRITIS AND CARTILAGE
- Multiple phospholipase A2 enzymes participate in the inflammatory process in osteoarthritic cartilage
- (2011) L Leistad et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis
- (2010) G. Zhai et al. ANNALS OF THE RHEUMATIC DISEASES
- Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
- (2010) J. L. Scott et al. ANNALS OF THE RHEUMATIC DISEASES
- Mitochondrial function, mitochondrial DNA and ageing: a reappraisal
- (2010) Giuseppe Passarino et al. BIOGERONTOLOGY
- Triacylglycerol Homeostasis: Insights from Yeast
- (2010) Sepp D. Kohlwein JOURNAL OF BIOLOGICAL CHEMISTRY
- Circulating mitochondrial DAMPs cause inflammatory responses to injury
- (2010) Qin Zhang et al. NATURE
- Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
- (2010) Taku Saito et al. NATURE MEDICINE
- Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
- (2010) Siyoung Yang et al. NATURE MEDICINE
- Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
- (2010) Mohit Kapoor et al. Nature Reviews Rheumatology
- Lipid metabolism and osteoarthritis: Lessons from atherosclerosis
- (2010) Vasiliki Gkretsi et al. PROGRESS IN LIPID RESEARCH
- Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor- B in human osteoarthritis chondrocytes
- (2010) Z. Rasheed et al. RHEUMATOLOGY
- Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis
- (2010) Stéphane Pallu et al. ARTHRITIS RESEARCH & THERAPY
- Amino acids: metabolism, functions, and nutrition
- (2009) Guoyao Wu AMINO ACIDS
- Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain
- (2009) I Rego et al. ANNALS OF THE RHEUMATIC DISEASES
- As a Matter of Fat
- (2009) Rita T. Brookheart et al. Cell Metabolism
- PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- (2009) Carles Cantó et al. CURRENT OPINION IN LIPIDOLOGY
- Mesenchymal stem cells in regenerative medicine: Opportunities and challenges for articular cartilage and intervertebral disc tissue engineering
- (2009) Stephen M. Richardson et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
- (2009) R.F. Loeser OSTEOARTHRITIS AND CARTILAGE
- Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression
- (2009) T. Piepoli et al. OSTEOARTHRITIS AND CARTILAGE
- Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis
- (2009) Z. Zainal et al. OSTEOARTHRITIS AND CARTILAGE
- Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes
- (2009) J. Kim et al. OSTEOARTHRITIS AND CARTILAGE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate
- (2009) Jonathan B Catterall et al. ARTHRITIS RESEARCH & THERAPY
- Arginine metabolism and nutrition in growth, health and disease
- (2008) Guoyao Wu et al. AMINO ACIDS
- Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes
- (2008) Berta Cillero-Pastor et al. ARTHRITIS AND RHEUMATISM
- Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined withSox9 viarAAV gene transfer
- (2008) Magali Cucchiarini et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Effects of hypoxia on glucose transport in primary equine chondrocytesin vitroand evidence of reduced GLUT1 gene expression in pathologic cartilagein vivo
- (2008) Siriporn Peansukmanee et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics
- (2008) Cristina Ruiz-Romero et al. MOLECULAR & CELLULAR PROTEOMICS
- Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
- (2008) Amber Buescher Johnson et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Osteoarthritis and nitric oxide
- (2008) Steven B. Abramson OSTEOARTHRITIS AND CARTILAGE
- Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes
- (2008) V.I. Grishko et al. OSTEOARTHRITIS AND CARTILAGE
- Epidemiology of Osteoarthritis
- (2008) Yuqing Zhang et al. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More