HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

(2018) Steve Stegen et al.   Nature Communications

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

(2017) Doriane Lorendeau et al.   METABOLIC ENGINEERING

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Osteogenesis imperfecta

(2017) Joan C. Marini et al.   Nature Reviews Disease Primers

Adequate hypoxia inducible factor 1α signaling is indispensable for bone regeneration

(2016) Steve Stegen et al.   BONE

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

(2016) Steve Stegen et al.   Cell Metabolism

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

Metabolic control of signalling pathways and metabolic auto-regulation

(2015) Doriane Lorendeau et al.   BIOLOGY OF THE CELL

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expansion of Murine Periosteal Progenitor Cells with Fibroblast Growth Factor 2 Reveals an Intrinsic Endochondral Ossification Program Mediated by Bone Morphogenetic Protein 2

(2014) Nick van Gastel et al.   STEM CELLS

Hypoxia-inducible Factor-1 (HIF-1) but Not HIF-2 Is Essential for Hypoxic Induction of Collagen Prolyl 4-Hydroxylases in Primary Newborn Mouse Epiphyseal Growth Plate Chondrocytes

(2012) Ellinoora Aro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

Development of micro-CT protocols for in vivo follow-up of mouse bone architecture without major radiation side effects

(2011) K. Laperre et al.   BONE

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival

(2011) Christa Maes et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypoxia. 2. Hypoxia regulates cellular metabolism

(2010) William W. Wheaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling

(2010) Jean-Paul Decuypere et al.   CELL CALCIUM

Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery

(2010) Erik Storkebaum et al.   CIRCULATION

Post-translational control of collagen fibrillogenesis in mineralizing cultures of chick osteoblasts

(2010) Louis C. Gerstenfeld et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

(2010) Kim Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

Location of 3-Hydroxyproline Residues in Collagen Types I, II, III, and V/XI Implies a Role in Fibril Supramolecular Assembly

(2009) Mary Ann Weis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

(2008) Johanna Myllyharju   ANNALS OF MEDICINE

TRPV4-Mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts

(2008) Ritsuko Masuyama et al.   Cell Metabolism

Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-α

(2008) Filip Callewaert et al.   FASEB JOURNAL