Review
Immunology
Rumi Hachiya, Miyako Tanaka, Michiko Itoh, Takayoshi Suganami
Summary: Chronic inflammation, particularly obesity-induced inflammation in adipose tissue, is considered as the molecular basis of metabolic syndrome. The crosstalk between different cell types in adipose tissue in obesity is not fully understood. The review highlights the role of innate immune receptors in the interaction between immune and metabolic systems in metabolic syndrome.
INFLAMMATION AND REGENERATION
(2022)
Review
Biology
Tamas Ilyes, Ciprian N. Silaghi, Alexandra M. Craciun
Summary: This article provides an overview and analysis of the variations of short-chain fatty acids (SCFAs) in obesity-related conditions, and their potential in disease monitoring. SCFAs have been shown to decrease weight gain and improve diseases related to obesity. Diet plays an important role in modifying SCFA levels, with high fiber-containing foods and supplements increasing SCFA production and showing bodyweight-lowering effects.
Article
Gastroenterology & Hepatology
Alexis Bretin, Beng San Yeoh, Vu L. Ngo, Lavanya Reddivari, Michael Pellizzon, Matam Vijay-Kumar, Andrew T. Gewirtz
Summary: The impacts of dietary fiber on intestinal inflammation are complex, but specific semi-purified fibers such as psyllium can protect against colitis. Psyllium's protection against colitis and metabolic syndrome is independent of the FXR bile acid receptor and fermentation, but requires the presence of a minimal microbiota. Psyllium enriches the high-fat diet and provides strong protection against gut inflammation and metabolic consequences induced by obesity.
Article
Biochemistry & Molecular Biology
Jorge L. Petro, Maria Carolina Fragozo-Ramos, Andres F. Milan, Juan C. Aristizabal, Jaime A. Gallo-Villegas, Juan C. Calderon
Summary: This cross-sectional study found that serum myonectin levels are lower in subjects with metabolic syndrome (MS) compared to those without MS. Serum myonectin is negatively correlated with the android/gynoid fat mass ratio, but not with lipid profile, free fatty acids, intramuscular lipid content, or insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Liqing Zang, Maedeh Baharlooeian, Masahiro Terasawa, Yasuhito Shimada, Norihiro Nishimura
Summary: Metabolic syndrome comprises a group of conditions that collectively increase the risk of abdominal obesity, diabetes, atherosclerosis, cardiovascular diseases, and cancer. Gut microbiota is involved in the pathogenesis of metabolic syndrome, and microbial diversity and function are strongly affected by diet. In recent years, epidemiological evidence has shown that the dietary intake of seaweed can prevent metabolic syndrome via gut microbiota modulation.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Sandra Maria Chemin Seabra da Silva, Aline de Piano Ganen, Deborah Cristina Landi Masquio, Marcus V. L. Dos Santos Quaresma, Debora Estadella, Lila Missae Oyama, Lian Tock, Marco Tulio de Mello, Ana Raimunda Damaso, Claudia Maria da Penha Oller do Nascimento, Danielle Arisa Caranti
Summary: This study aimed to verify the relationships between serum-free fatty acids (FA), inflammatory processes, and depressive symptoms in obese adolescents. The results showed positive correlations between depressive symptoms and saturated fatty acids (SFA) content, body fat, and inflammatory adipokines. On the other hand, n-3 polyunsaturated fatty acids (PUFA) content was negatively correlated with depressive symptoms. However, further longitudinal studies are needed to confirm the causality between dietary SFA and depression in obese individuals.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Iwona Boniecka, Aneta Czerwonogrodzka-Senczyna, Anna Jeznach-Steinhagen, Krzysztof Pasnik, Dorota Szostak-Wegierek, Samir Zeair
Summary: Bariatric surgery is the most effective treatment for obesity and its complications, but failure to adhere to dietary recommendations can lead to unsatisfactory weight loss and metabolic disorders. This study aimed to evaluate the effects of bariatric surgery on anthropometric parameters and nutrient intake.
Article
Gastroenterology & Hepatology
Clara Depommier, Amandine Everard, Celine Druart, Dominique Maiter, Jean-Paul Thissen, Audrey Loumaye, Michel P. Hermans, Nathalie M. Delzenne, Willem M. de Vos, Patrice D. Cani
Summary: The reduction of A. muciniphila in the gut microbiota is associated with obesity-related metabolic disorders. Metabolomics profiling revealed that administration of different forms of A. muciniphila can lead to alterations in amino acid metabolism and induction of ketogenesis through enhanced beta-oxidation. Additionally, certain metabolites emerged as significant compounds related to health and diseases.
Review
Nutrition & Dietetics
Mohamad Khalil, Harshitha Shanmugam, Hala Abdallah, Jerlin Stephy John Britto, Ilaria Galerati, Javier Gomez-Ambrosi, Gema Fruhbeck, Piero Portincasa
Summary: Abnormal expansion of body fat leads to metabolic abnormalities and increases the risk of cardiovascular disease. Adopting a healthy diet, such as the Mediterranean diet, can improve mitochondrial function and metabolism.
Article
Nutrition & Dietetics
Natalia Kopiczko, Anna Bobrus-Chociej, Ewa Harasim-Symbor, Eugeniusz Tarasow, Malgorzata Wojtkowska, Adrian Chabowski, Dariusz M. Lebensztejn
Summary: This study aimed to evaluate the serum FA concentration in children with obesity and NAFLD. The results showed that the total FA concentration was significantly higher in obese children and in obese children with NAFLD compared to controls. There was a significant positive correlation between total FA concentration and cholesterol, triacylglycerols, and insulin in children with NAFLD.
Article
Medicine, General & Internal
Peter Arner, Mikael Ryden
Summary: Recent technological advancements have allowed researchers to determine the age of fat cells and their lipids in adults. Contrary to previous beliefs, these studies have shown that fat cells have a high turnover rate of 10% per year, with their lipid droplets being replaced six times every 10 years. Obesity and having many small fat cells (hyperplasia) increase fat cell turnover. While weight gain increases both the number and size of fat cells, weight loss only affects the size (decreasing), which may contribute to weight regain. Subjects with excess body fat have reduced fat cell lipid turnover. This dysregulation is observed in the subcutaneous region in overweight individuals and in the visceral depot only in severe obesity. This helps explain why visceral fat is particularly detrimental in the overweight/obese state, as it allows for faster lipid fluxes between the visceral fat and the liver. Adipose lipid turnover decreases with age due to impaired breakdown of stored triglycerides. If this decline is not compensated by reduced lipid uptake by adipocytes, bodyweight will increase over time. Low rates of lipolysis are a risk factor for future weight gain and glucose intolerance. Adipose lipid turnover is also decreased in insulin resistance and certain forms of dyslipidemia. In summary, adult adipose tissue is highly dynamic, and alterations in fat cell and lipid turnover are novel factors to consider in the pathophysiology of common metabolic disorders.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Cristina Bellarosa, Giorgio Bedogni, Annalisa Bianco, Sabrina Cicolini, Diana Caroli, Claudio Tiribelli, Alessandro Sartorio
Summary: Obesity plays a central role in the development of metabolic syndrome and non-alcoholic fatty liver disease in children, with serum bilirubin concentrations showing an inverse association with certain components of metabolic syndrome. However, bilirubin does not appear to be protective against metabolic syndrome and non-alcoholic fatty liver disease in severe obesity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Junki Miyamoto, Hidenori Shimizu, Keiko Hisa, Chiaki Matsuzaki, Shinsuke Inuki, Yuna Ando, Akari Nishida, Ayano Izumi, Mayu Yamano, Chihiro Ushiroda, Junichiro Irie, Takane Katayama, Hiroaki Ohno, Hiroshi Itoh, Kenji Yamamoto, Ikuo Kimura
Summary: Fermented foods have health benefits due to probiotic bacteria or microproducts produced by bacterial fermentation. Prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) show significant metabolic benefits. EPS-derived gut microbial short-chain fatty acids improve glucose metabolism and energy homeostasis, and alter gut microbial composition.
Article
Multidisciplinary Sciences
Wenwen Huang, Yiping Zhang, Liping Zhong, Chunlong Sun, Zaiwang Zhang
Summary: A new method for determining the isomers of palmitoleic acid, cPOA and tPOA, has been developed and successfully applied in pharmacokinetic studies in rat serum. Fluctuating concentrations of cPOA and tPOA in rat serum were observed, suggesting reciprocal bio-conversion in the body.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Mimi S. Kim, Nicole R. Fraga, Nare Minaeian, Mitchell E. Geffner
Summary: Classical CAH patients have a higher prevalence of cardiovascular metabolic risk factors, although the complete metabolic syndrome is relatively rare in children and adolescents. Understanding the traditional and non-traditional risk factors in CAH patients can guide treatment options and prevent the onset of metabolic syndrome in adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Angelica M. Munoz, Claudia M. Velasquez, Gabriel Bedoya
Article
Nutrition & Dietetics
Gloria M. Agudelo-Ochoa, Isabel C. Pulgarin-Zapata, Claudia M. Velasquez-Rodriguez, Mauricio Duque-Ramirez, Mauricio Naranjo-Cano, Monica M. Quintero-Ortiz, Oscar J. Lara-Guzman, Katalina Munoz-Durango
JOURNAL OF NUTRITION
(2016)
Article
Neurosciences
Javier G. Villamil-Ortiz, Alvaro Barrera-Ocampo, Diego Piedrahita, Claudia M. Velasquez-Rodriguez, Julian D. Arias-Londono, Gloria P. Cardona-Gomez
FRONTIERS IN CELLULAR NEUROSCIENCE
(2016)
Article
Food Science & Technology
Julian Zuluaga Rodriguez, Claudia Maria Ramirez Botero, Sara Elisa Gallego Rios, Gustavo A. Penuela, Sara M. Macias, Beatriz Estella Lopez Marin, Jenny Leal Florez, Claudia M. Velasquez Rodriguez
JOURNAL OF AQUATIC FOOD PRODUCT TECHNOLOGY
(2017)
Article
Tropical Medicine
Ana C. Orozco, Angelica M. Munoz, Claudia M. Velasquez, Rosa M. Uscategui, Maria V. Parra, Fredy A. Patino, Luz M. Manjarres, Beatriz E. Parra, Alejandro Estrada, Gloria M. Agudelo
Article
Pediatrics
Claudia-Maria Velasquez-Rodriguez, Marcela Velasquez-Villa, Leidy Gomez-Ocampo, Juliana Bermudez-Cardona
Article
Gastroenterology & Hepatology
Carlos Bernal, Claudia Velasquez, Gloria Alcaraz, Jorge Botero
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2008)
Article
Medicine, Research & Experimental
Gloria M. Agudelo, Gabriel Bedoya, Alejandro Estrada, Fredy A. Patino, Angelica M. Munoz, Claudia M. Velasquez
METABOLIC SYNDROME AND RELATED DISORDERS
(2014)
Article
Nutrition & Dietetics
J. A. Bermudez, C. M. Velasquez
ARCHIVOS LATINOAMERICANOS DE NUTRICION
(2014)
Article
Tropical Medicine
Nora Elena Munera, Rosa Magdalena Uscategui, Beatriz Elena Parra, Luz Mariela Manjarres, Fredy Patino, Claudia Maria Velasquez, Alejandro Estrada, Gabriel Bedoya, Vicky Parra, Angelica Maria Munoz, Ana Carolina Orozco, Gloria Maria Agudelo
Article
Nutrition & Dietetics
R. Claudia Velasquez, C. Juliana Bermudez, V. Claudia Echeverri, R. Alejandro Estrada
ARCHIVOS LATINOAMERICANOS DE NUTRICION
(2011)
Review
Medicine, General & Internal
Viviana Taylor Bacteriol, Claudia Velasquez, Luis C. Burgos, Jaime Carmona, Adriana Correa, Amanda Maestre, Rosa Uscategui
Article
Medicine, General & Internal
Claudia Velasquez, Carolina Navarro, Cesar Munoz, Angel Gonzalez