Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration

Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis

(2015) Keiji Kobayashi et al.   Scientific Reports

Collagen peptide and vitamin C additively attenuate age-related skin atrophy inSod1-deficient mice

(2014) Shuichi Shibuya et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro

(2014) LEI JIN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

TRPV4 as a therapeutic target for joint diseases

(2014) Amy L. McNulty et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Preventive effects of hyaluronan from deterioration of gait parameters in surgically induced mice osteoarthritic knee model

(2014) Y. Muramatsu et al.   OSTEOARTHRITIS AND CARTILAGE

Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model

(2014) Lingling Zeng et al.   PLoS One

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac Electrophysiological Alterations in Heart/Muscle-Specific Manganese-Superoxide Dismutase-Deficient Mice: Prevention by a Dietary Antioxidant Polyphenol

(2014) Tadahiro Sunagawa et al.   Biomed Research International

Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction

(2013) John F. Bateman et al.   ARTHRITIS AND RHEUMATISM

Sod1 Loss Induces Intrinsic Superoxide Accumulation Leading to p53-Mediated Growth Arrest and Apoptosis

(2013) Kenji Watanabe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis

(2013) R.K. Chaganti et al.   OSTEOARTHRITIS AND CARTILAGE

Disease Progression and Phasic Changes in Gene Expression in a Mouse Model of Osteoarthritis

(2013) Richard F. Loeser et al.   PLoS One

MiR-146a Regulates SOD2 Expression in H2O2 Stimulated PC12 Cells

(2013) Guohua Ji et al.   PLoS One

Increased susceptibility ofTrpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet

(2012) Christopher J O'Conor et al.   ANNALS OF THE RHEUMATIC DISEASES

Biomechanical factors in osteoarthritis

(2012) Farshid Guilak   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

Effects of aging on articular cartilage homeostasis

(2012) Martin Lotz et al.   BONE

Mechanical stress and ATP synthesis are coupled by mitochondrial oxidants in articular cartilage

(2012) Katherine J. Wolff et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Procyanidin B3 Prevents Articular Cartilage Degeneration and Heterotopic Cartilage Formation in a Mouse Surgical Osteoarthritis Model

(2012) Hailati Aini et al.   PLoS One

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

(2012) Jing Li et al.   ARTHRITIS RESEARCH & THERAPY

Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling

(2011) Aaron H. Bubolz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Future therapeutics for osteoarthritis

(2011) Johanne Martel-Pelletier et al.   BONE

Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice

(2011) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking

(2011) Hidetoshi Nojiri et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

Model mice for tissue-specific deletion of the manganese superoxide dismutase gene

(2010) Takahiko Shimizu et al.   Geriatrics & Gerontology International

Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Toshihiko Toda et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Hypoxia, RONS and energy metabolism in articular cartilage

(2010) B. Fermor et al.   OSTEOARTHRITIS AND CARTILAGE

Basic methods in histopathology of joint tissues

(2010) N. Schmitz et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative

(2009) Kazuma Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antioxidant, EUK-8, Prevents Murine Dilated Cardiomyopathy

(2009) Satoru Kawakami et al.   CIRCULATION JOURNAL

Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study

(2009) Noriko Yoshimura et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols

Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury

(2008) E.A. Regan et al.   OSTEOARTHRITIS AND CARTILAGE