Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

(2015) Nobuhiko Hiramatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Chondroinduction Is the Main Cartilage Repair Response to Microfracture and Microfracture With BST-CarGel

(2015) Caroline D. Hoemann et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

(2015) Faezeh Vasheghani et al.   ANNALS OF THE RHEUMATIC DISEASES

Apoptosis in mammalian oocytes: a review

(2015) Meenakshi Tiwari et al.   APOPTOSIS

Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment

(2015) Samira Goldar et al.   Asian Pacific Journal of Cancer Prevention

The BCL-2 protein family, BH3-mimetics and cancer therapy

(2015) A R D Delbridge et al.   CELL DEATH AND DIFFERENTIATION

Targeting PI3K/AKT/mTOR network for treatment of leukemia

(2015) Jessika Bertacchini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Core Binding Factor β Plays a Critical Role During Chondrocyte Differentiation

(2015) Na-Rae Park et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Repair of massively defected hemi-joints using demineralized osteoarticular allografts with protected cartilage

(2015) Siming Li et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis

(2015) Ali Mobasheri et al.   MATURITAS

The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model

(2015) K.A. Elsaid et al.   OSTEOARTHRITIS AND CARTILAGE

Matrix cross-linking–mediated mechanotransduction promotes posttraumatic osteoarthritis

(2015) Jin-Hong Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guided differentiation of bone marrow stromal cells on co-cultured cartilage and bone scaffolds

(2015) Paul Lee et al.   Soft Matter

Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments

(2015) Xiaohong Yang et al.   ARTHRITIS RESEARCH & THERAPY

Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes

(2015) Paloma López de Figueroa et al.   Arthritis & Rheumatology

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

(2014) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia–ischemia: Role of protein synthesis and autophagic pathways

(2014) Silvia Carloni et al.   EXPERIMENTAL NEUROLOGY

Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro

(2014) LEI JIN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Up-regulation of the chemo-attractive receptor ChemR23 and occurrence of apoptosis in human chondrocytes isolated from fractured calcaneal osteochondral fragments

(2014) Paola Sena et al.   JOURNAL OF ANATOMY

Autophagy in human articular chondrocytes is cytoprotective following glucocorticoid stimulation

(2014) NING LIU et al.   Molecular Medicine Reports

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein

(2014) Y. Uehara et al.   OSTEOARTHRITIS AND CARTILAGE

Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease

(2014) Jana Hroudová et al.   Biomed Research International

Subchondral Bone Plate Thickening Precedes Chondrocyte Apoptosis and Cartilage Degradation in Spontaneous Animal Models of Osteoarthritis

(2014) Zaitunnatakhin Zamli et al.   Biomed Research International

Aging and Oxidative Stress Reduce the Response of Human Articular Chondrocytes to Insulin-like Growth Factor 1 and Osteogenic Protein 1

(2014) Richard F. Loeser et al.   Arthritis & Rheumatology

Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes

(2013) Soichiro Yamabe et al.   FEBS Journal

The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis

(2013) JUN CHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Identification of CD163 Expressing Phagocytic Chondrocytes in Joint Cartilage and Its Novel Scavenger Role in Cartilage Degradation

(2013) Kai Jiao et al.   PLoS One

C/EBP homologous protein drives pro-catabolic responses in chondrocytes

(2013) Matt Husa et al.   ARTHRITIS RESEARCH & THERAPY

Granzyme B in injury, inflammation, and repair

(2012) Paul R. Hiebert et al.   TRENDS IN MOLECULAR MEDICINE

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

(2012) Jing Li et al.   ARTHRITIS RESEARCH & THERAPY

D469del-COMP Retention in Chondrocytes Stimulates Caspase-Independent Necroptosis

(2011) Françoise Coustry et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection

(2011) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

(2011) Hiroshi Sasaki et al.   ARTHRITIS AND RHEUMATISM

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage

(2011) Koji Takada et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Chondrocyte apoptosis: a cause or consequence of osteoarthritis?

(2011) Zaitunnatakhin ZAMLI et al.   International Journal of Rheumatic Diseases

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1

(2010) Wasanthi Subasinghe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Autophagy Signaling Through Reactive Oxygen Species

(2010) Ju Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

(2010) Martin K Lotz   ARTHRITIS RESEARCH & THERAPY

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy

(2009) Jolene Bohensky et al.   ARTHRITIS AND RHEUMATISM

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

(2009) Margaret A. Knowles et al.   CANCER AND METASTASIS REVIEWS

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced Osteoarthritis in Humans Is Associated With Altered Collagen VI Expression and Upregulation of ER-stress Markers Grp78 and Bag-1

(2009) Ashleigh E. Nugent et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Mitochondrial gateways to cancer

(2009) Lorenzo Galluzzi et al.   MOLECULAR ASPECTS OF MEDICINE

FLIP-mediated autophagy regulation in cell death control

(2009) Jong-Soo Lee et al.   NATURE CELL BIOLOGY

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Involvement of p38 MAPK in regulation of MMP13 mRNA in chondrocytes in response to surviving stress to endoplasmic reticulum

(2008) Kazunori Hamamura et al.   ARCHIVES OF ORAL BIOLOGY

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21

(2008) John W. Blankenship et al.   BIOCHEMICAL JOURNAL

Cell death in the host response to infection

(2008) K Labbé et al.   CELL DEATH AND DIFFERENTIATION

Tumor resistance to apoptosis

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF CANCER

Caspases as therapeutic targets

(2008) B. Howley et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE

Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis

(2008) Cristina Ruiz-Romero et al.   PROTEOMICS

Biomechanics and mechanobiology in osteochondral tissues

(2008) LA McMahon et al.   Regenerative Medicine

Gene Regulation by Transcription Factors and MicroRNAs

(2008) O. Hobert   SCIENCE