期刊
AMINO ACIDS
卷 48, 期 4, 页码 907-914出版社
SPRINGER WIEN
DOI: 10.1007/s00726-015-2168-x
关键词
Arginine; Glutamate; Glutamine; Inflammation; Osteoarthritis
资金
- National Natural Science Foundation of China [81201420, 81272034, 81402224, 81472130]
- Provincial Science Foundation of Hunan [14JJ3032, 2015JJ3139]
- Development and Reform Commission of Hunan Province [[2013]1199, [2014]6588]
- Science and Technology Office of Hunan Province [2012FJ6001, 2013SK2018]
- Science and Technology Office of Changsha City [K1203040-31]
- Health and Family Planning Commission of Hunan Province [B2014-12]
- Administration of Traditional Chinese Medicine of Hunan Province [2015115]
- Texas A&M AgriLife Research [H-8200]
Osteoarthritis (OA) is a common form of arthritis in humans. It has long been regarded as a non-inflammatory disease, but a degree of inflammation is now recognized as being a vital inducer of subpopulation of OA. Besides inflammation, the establishment and development of OA are associated with alterations in metabolism and profiles of amino acids (AA), including glutamate- and arginine-family AA as well as their related metabolites (e.g., creatinine, hydroxyproline, gamma-aminobutyrate, dimethylarginines and homoarginine). Functional AA (e.g., glutamine, arginine, glutamate, glycine, proline, and tryptophan) have various benefits (i.e., anti-inflammation and anti-oxidation) in treatment of inflammation-associated diseases, including OA. Thus, these AA have potential as immunomodulatory nutrients for patients with inflammation-induced OA.
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