标题
Harnessing Cerebrospinal Fluid Circulation for Drug Delivery to Brain Tissues
作者
关键词
CSF Flow, Glymphatic system, CSF pharmacokinetics, Intrathecal, Formulation, Imaging, Modeling, Clinical disorders, Clinical studies, Devices
出版物
ADVANCED DRUG DELIVERY REVIEWS
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2021-03-09
DOI
10.1016/j.addr.2021.03.002
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Intrathecal drug delivery in the era of nanomedicine
- (2020) M. Fowler et al. ADVANCED DRUG DELIVERY REVIEWS
- Guide to preclinical models used to study the pathophysiology of idiopathic intracranial hypertension
- (2020) Zerin Alimajstorovic et al. EYE
- Perivascular spaces in the brain: anatomy, physiology and pathology
- (2020) Joanna M. Wardlaw et al. Nature Reviews Neurology
- Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus
- (2020) Benjamin C. Reeves et al. TRENDS IN MOLECULAR MEDICINE
- Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain
- (2020) William M. Pardridge Frontiers in Aging Neuroscience
- Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?
- (2020) Marco Cavaco et al. Pharmaceutics
- Intrathecal Antibacterial and Antifungal Therapies
- (2020) Roland Nau et al. CLINICAL MICROBIOLOGY REVIEWS
- Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial
- (2020) Kazuyuki Shimada et al. LANCET ONCOLOGY
- The Brain’s Glymphatic System: Current Controversies
- (2020) Humberto Mestre et al. TRENDS IN NEUROSCIENCES
- A roadmap for potassium buffering/dispersion via the glial network of the CNS
- (2020) Marie E. Beckner NEUROCHEMISTRY INTERNATIONAL
- Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
- (2020) Timothy Miller et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting nanoparticles to the brain by exploiting the blood–brain barrier impermeability to selectively label the brain endothelium
- (2020) Daniel Gonzalez-Carter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intraventricular Hemorrhage Clearance in Human Neonatal Cerebrospinal Fluid
- (2020) Kelly B. Mahaney et al. STROKE
- Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
- (2020) Federico N. Soria et al. Nature Communications
- Treatment response to intrathecal chemotherapy with pemetrexed via an Ommaya reservoir in EGFR-mutated leptomeningeal metastases from non-small cell lung cancer: a case report
- (2020) Huiying Li et al. Annals of Palliative Medicine
- Cerebral Microdialysis as a Tool for Assessing the Delivery of Chemotherapy in Brain Tumor Patients
- (2020) Charles F. Pierce et al. World Neurosurgery
- Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study
- (2019) Todd Mainprize et al. Scientific Reports
- Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges
- (2019) Victor M. Pulgar Frontiers in Neuroscience
- Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia
- (2019) Lauren M. Hablitz et al. Science Advances
- Intrathecal cell therapy with autologous stromal cells increases cerebral glucose metabolism and can offer a new approach to the treatment of Alzheimer's type dementia
- (2019) JESÚS VAQUERO et al. CYTOTHERAPY
- Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies
- (2019) Neil A. Miller et al. CLINICAL PHARMACOKINETICS
- Clinical outcomes of breast leptomeningeal disease treated with intrathecal trastuzumab, intrathecal chemotherapy, or whole brain radiation therapy
- (2019) Nicholas B. Figura et al. BREAST CANCER RESEARCH AND TREATMENT
- A translational platform PBPK model for antibody disposition in the brain
- (2019) Hsueh-Yuan Chang et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Nose to brain delivery
- (2019) Ijeoma Uchegbu et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs
- (2019) Tuomas O. Lilius et al. JOURNAL OF CONTROLLED RELEASE
- Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients
- (2019) Christopher Duma et al. MOLECULAR BIOLOGY REPORTS
- Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
- (2019) Ji Hoon Ahn et al. NATURE
- Respiratory influence on cerebrospinal fluid flow – a computational study based on long-term intracranial pressure measurements
- (2019) Vegard Vinje et al. Scientific Reports
- Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis
- (2019) Laurens F. M. Verscheijden et al. PLoS Computational Biology
- Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
- (2019) Steven William Bothwell et al. Fluids and Barriers of the CNS
- Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields
- (2019) Matteo Croci et al. Fluids and Barriers of the CNS
- Fluid dynamics of cerebrospinal fluid flow in perivascular spaces
- (2019) John H. Thomas Journal of the Royal Society Interface
- Myelomeningocele-associated hydrocephalus: nationwide analysis and systematic review
- (2019) David J. McCarthy et al. Neurosurgical Focus
- Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice
- (2019) K. T. Householder et al. Scientific Reports
- Convection-Enhanced Delivery: Connection to and Impact of Interstitial Fluid Flow
- (2019) Caleb A. Stine et al. Frontiers in Oncology
- A multiple-network poroelastic model for biological systems and application to subject-specific modelling of cerebral fluid transport
- (2019) Liwei Guo et al. INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
- Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats
- (2019) Xuezhu Cai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In Vivo Intrathecal Tracer Dispersion in Cynomolgus Monkey Validates Wide Biodistribution Along Neuraxis
- (2019) Kevin Tangen et al. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
- The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?
- (2018) N. Joan Abbott et al. ACTA NEUROPATHOLOGICA
- The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future
- (2018) Benjamin A. Plog et al. Annual Review of Pathology-Mechanisms of Disease
- Colloidal stability as a determinant of nanoparticle behavior in the brain
- (2018) Chad Curtis et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach
- (2018) Yumi Yamamoto et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- On the bulk motion of the cerebrospinal fluid in the spinal canal
- (2018) A. L. Sánchez et al. JOURNAL OF FLUID MECHANICS
- Antibody pharmacokinetics in rat brain determined using microdialysis
- (2018) Hsueh-Yuan Chang et al. mAbs
- Best practices for the use of intracerebroventricular drug delivery devices
- (2018) Irene Slavc et al. MOLECULAR GENETICS AND METABOLISM
- Clinical Trial Protocol: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage [NEWTON-2 (Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After SubarachNoid Hemorrhage)]
- (2018) Daniel Hänggi et al. Neurocritical Care
- Study of Intraventricular Cerliponase Alfa for CLN2 Disease
- (2018) Angela Schulz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cotransporter-mediated water transport underlying cerebrospinal fluid formation
- (2018) Annette B. Steffensen et al. Nature Communications
- General Anesthesia Inhibits the Activity of the “Glymphatic System”
- (2018) Clement Gakuba et al. Theranostics
- Cannula Implantation into the Cisterna Magna of Rodents
- (2018) Anna L.R. Xavier et al. Jove-Journal of Visualized Experiments
- Immunogenicity to cerliponase alfa intracerebroventricular enzyme replacement therapy for CLN2 disease: Results from a Phase 1/2 study
- (2018) Anu Cherukuri et al. CLINICAL IMMUNOLOGY
- Preliminary Safety and Tolerability of a Novel Subcutaneous Intrathecal Catheter System for Repeated Outpatient Dosing of Nusinersen to Children and Adults With Spinal Muscular Atrophy
- (2018) Kevin A. Strauss et al. JOURNAL OF PEDIATRIC ORTHOPAEDICS
- Sensitive targeted methods for brain metabolomic studies in microdialysis samples
- (2018) Jana Bongaerts et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
- (2018) Sandro Da Mesquita et al. NATURE
- New Insight Into The Mechanism Of Mannitol Effects On Cerebrospinal Fluid Pressure Decrease And Craniospinal Fluid Redistribution
- (2018) Darko Orešković et al. NEUROSCIENCE
- The synthesized transporter K16APoE enabled the therapeutic HAYED peptide to cross the blood-brain barrier and remove excess iron and radicals in the brain, thus easing Alzheimer’s disease
- (2018) Zhenyou Zou et al. Drug Delivery and Translational Research
- Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus
- (2018) Md Mahdi Hasan-Olive et al. GLIA
- Infusion of 5-Azacytidine (5-AZA) into the fourth ventricle or resection cavity in children with recurrent posterior Fossa Ependymoma: a pilot clinical trial
- (2018) David I. Sandberg et al. JOURNAL OF NEURO-ONCOLOGY
- Intrathecal administration of nusinersen in adolescent and adult SMA type 2 and 3 patients
- (2018) Claudia D. Wurster et al. JOURNAL OF NEUROLOGY
- The glymphatic pathway in neurological disorders
- (2018) Martin Kaag Rasmussen et al. LANCET NEUROLOGY
- Intrathecal treatment trial of rituximab in progressive MS
- (2018) Joakim Bergman et al. NEUROLOGY
- Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension
- (2018) Temel Fatih Yılmaz et al. Radiologia Medica
- Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
- (2018) Humberto Mestre et al. Nature Communications
- Aquaporin-4-dependent glymphatic solute transport in the rodent brain
- (2018) Humberto Mestre et al. eLife
- Homeostasis and the concept of 'interstitial fluids hierarchy': Relevance of cerebrospinal fluid sodium concentrations and brain temperature control (Review)
- (2017) Luigi F. Agnati et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Nonuniform Moving Boundary Method for Computational Fluid Dynamics Simulation of Intrathecal Cerebrospinal Flow Distribution in a Cynomolgus Monkey
- (2017) Mohammadreza Khani et al. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
- Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
- (2017) Antoine Louveau et al. JOURNAL OF CLINICAL INVESTIGATION
- Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real-time phase-contrast MRI
- (2017) Selda Yildiz et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery
- (2017) Michelle E. Pizzo et al. JOURNAL OF PHYSIOLOGY-LONDON
- Ventriculo-peritoneal shunt surgery for tuberculous meningitis: A systematic review
- (2017) Imran Rizvi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Role of choroid plexus in cerebrospinal fluid hydrodynamics
- (2017) Darko Orešković et al. NEUROSCIENCE
- Systemic autoimmune diseases complicated with hydrocephalus: pathogenesis and management
- (2017) Junji Wei et al. NEUROSURGICAL REVIEW
- Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration
- (2017) Jessica L. Cohen-Pfeffer et al. PEDIATRIC NEUROLOGY
- Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow
- (2017) Karl Erik Holter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications
- (2017) Yiming Lei et al. PROGRESS IN NEUROBIOLOGY
- Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
- (2017) Qiaoli Ma et al. Nature Communications
- The ultrastructure of spinal cord perivascular spaces: Implications for the circulation of cerebrospinal fluid
- (2017) Magdalena A. Lam et al. Scientific Reports
- Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma
- (2017) Alex J Smith et al. eLife
- Quantitative Visualization of Dynamic Tracer Transportation in the Extracellular Space of Deep Brain Regions Using Tracer-Based Magnetic Resonance Imaging
- (2017) Jin Hou et al. MEDICAL SCIENCE MONITOR
- Cerebrospinal Fluid Mechanics and Its Coupling to Cerebrovascular Dynamics
- (2016) Andreas A. Linninger et al. Annual Review of Fluid Mechanics
- Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data
- (2016) Lu Gaohua et al. Drug Metabolism and Pharmacokinetics
- CSF, blood-brain barrier, and brain drug delivery
- (2016) William M. Pardridge Expert Opinion on Drug Delivery
- A fully dynamic multi-compartmental poroelastic system: Application to aqueductal stenosis
- (2016) Dean Chou et al. JOURNAL OF BIOMECHANICS
- Chronic, intermittent convection-enhanced delivery devices
- (2016) Owen Lewis et al. JOURNAL OF NEUROSCIENCE METHODS
- Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration
- (2016) Patrick E. Trapa et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A phase 1/2 study of intrathecal heparan-N-sulfatase in patients with mucopolysaccharidosis IIIA
- (2016) Simon A. Jones et al. MOLECULAR GENETICS AND METABOLISM
- Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain
- (2016) Antoine G. Godin et al. Nature Nanotechnology
- Direct, long-term intrathecal application of therapeutics to the rodent CNS
- (2016) Benjamin V Ineichen et al. Nature Protocols
- A classification system of spontaneous spinal CSF leaks
- (2016) Wouter I. Schievink et al. NEUROLOGY
- New Concepts of Cerebrospinal Fluid Physiology and Development of Hydrocephalus
- (2016) Darko Orešković et al. PEDIATRIC NEUROSURGERY
- A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations
- (2016) Yumi Yamamoto et al. PHARMACEUTICAL RESEARCH
- Cilia-based flow network in the brain ventricles
- (2016) R. Faubel et al. SCIENCE
- Multifaceted interactions between adaptive immunity and the central nervous system
- (2016) J. Kipnis SCIENCE
- Osmolality of Cerebrospinal Fluid from Patients with Idiopathic Intracranial Hypertension (IIH)
- (2016) Elisabeth A. Wibroe et al. PLoS One
- Glymphatic solute transport does not require bulk flow
- (2016) Mahdi Asgari et al. Scientific Reports
- Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
- (2015) Richard S. Geary et al. ADVANCED DRUG DELIVERY REVIEWS
- Comparative Analysis by Magnetic Resonance Imaging of Extracellular Space Diffusion and Interstitial Fluid Flow in the Rat Striatum and Thalamus
- (2015) Long Zuo et al. APPLIED MAGNETIC RESONANCE
- Ventricular access device placement in the fourth ventricle to treat malignant fourth ventricle brain tumors: technical note
- (2015) David I. Sandberg et al. CHILDS NERVOUS SYSTEM
- Is There A Pulse Wave Encephalopathy Component To Multiple Sclerosis?
- (2015) Bernhard Juurlink CURRENT NEUROVASCULAR RESEARCH
- Spinal anaesthesia with low-dose bupivacaine in marginally hyperbaric solutions for caesarean section
- (2015) Wen-Xi Tang et al. EUROPEAN JOURNAL OF ANAESTHESIOLOGY
- A balanced view of choroid plexus structure and function: Focus on adult humans
- (2015) Reynold Spector et al. EXPERIMENTAL NEUROLOGY
- Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson’s disease patients
- (2015) Gesine Paul et al. JOURNAL OF CLINICAL INVESTIGATION
- Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging
- (2015) Daniel J. Wolak et al. JOURNAL OF CONTROLLED RELEASE
- A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
- (2015) Aleksanteri Aspelund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Safety of intra-cerebrospinal fluid chemotherapy in onco-haematological patients: a retrospective analysis of 627 interventions
- (2015) Javier Pardo-Moreno et al. JOURNAL OF NEURO-ONCOLOGY
- Methotrexate administration directly into the fourth ventricle in children with malignant fourth ventricular brain tumors: a pilot clinical trial
- (2015) David I. Sandberg et al. JOURNAL OF NEURO-ONCOLOGY
- Current status of intratumoral therapy for glioblastoma
- (2015) Ankit I. Mehta et al. JOURNAL OF NEURO-ONCOLOGY
- The Molecular Mechanisms of Neural Flow Coupling: A New Concept
- (2015) Tsutomu Nakada JOURNAL OF NEUROIMAGING
- The Effect of Body Posture on Brain Glymphatic Transport
- (2015) H. Lee et al. JOURNAL OF NEUROSCIENCE
- Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System
- (2015) B. A. Plog et al. JOURNAL OF NEUROSCIENCE
- Inspiration Is the Major Regulator of Human CSF Flow
- (2015) S. Dreha-Kulaczewski et al. JOURNAL OF NEUROSCIENCE
- Development of the Metronomic Biofeedback Pump for leptomeningeal carcinomatosis: technical note
- (2015) Thomas C. Chen et al. JOURNAL OF NEUROSURGERY
- Click-crosslinked injectable hyaluronic acid hydrogel is safe and biocompatible in the intrathecal space for ultimate use in regenerative strategies of the injured spinal cord
- (2015) T. Führmann et al. METHODS
- Determination of the role of injection site on the efficacy of intra-CSF enzyme replacement therapy in MPS IIIA mice
- (2015) Helen Beard et al. MOLECULAR GENETICS AND METABOLISM
- Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann–Pick C1
- (2015) Timothy J. Maarup et al. MOLECULAR GENETICS AND METABOLISM
- Structural and functional features of central nervous system lymphatic vessels
- (2015) Antoine Louveau et al. NATURE
- Clearance systems in the brain—implications for Alzheimer disease
- (2015) Jenna M. Tarasoff-Conway et al. Nature Reviews Neurology
- Development and functions of the choroid plexus–cerebrospinal fluid system
- (2015) Melody P. Lun et al. NATURE REVIEWS NEUROSCIENCE
- Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma
- (2015) Rajneet K. Oberoi et al. NEURO-ONCOLOGY
- The Glymphatic System: A Beginner’s Guide
- (2015) Nadia Aalling Jessen et al. NEUROCHEMICAL RESEARCH
- Muddying the water in brain edema?
- (2015) Alex J. Smith et al. TRENDS IN NEUROSCIENCES
- Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation
- (2015) Chunyan Shi et al. Scientific Reports
- Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
- (2015) Sethu Sankaranarayanan et al. PLoS One
- Impairment of paravascular clearance pathways in the aging brain
- (2014) Benjamin T. Kress et al. ANNALS OF NEUROLOGY
- Development and validation of a liquid chromatography/tandem mass spectrometry method for the quantification of flucloxacillin and cloxacillin in microdialysis samples
- (2014) Karin H. M. Larmené-Beld et al. BIOMEDICAL CHROMATOGRAPHY
- Enigma of cerebrospinal fluid dynamics
- (2014) Marijan Klarica et al. CROATIAN MEDICAL JOURNAL
- A proposed role for efflux transporters in the pathogenesis of hydrocephalus
- (2014) Satish Krishnamurthy et al. CROATIAN MEDICAL JOURNAL
- Cerebrospinal fluid physiology: visualization of cerebrospinal fluid dynamics using the magnetic resonance imaging Time-Spatial Inversion Pulse method
- (2014) Shinya Yamada CROATIAN MEDICAL JOURNAL
- A computational model of cerebrospinal fluid production and reabsorption driven by Starling forces
- (2014) Joel Buishas et al. CROATIAN MEDICAL JOURNAL
- A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastoma
- (2014) Neil U. Barua et al. DRUG DELIVERY
- Gliotoxin-induced swelling of astrocytes hinders diffusion in brain extracellular space via formation of dead-space microdomains
- (2014) Ang Doma Sherpa et al. GLIA
- Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood−brain barrier using MRI-guided focused ultrasound
- (2014) Elizabeth Nance et al. JOURNAL OF CONTROLLED RELEASE
- Ventriculolumbar Perfusion Chemotherapy With Methotrexate for Treating Leptomeningeal Carcinomatosis: A Phase II Study
- (2014) H.-S. Gwak et al. ONCOLOGIST
- Intrathecal delivery of protein therapeutics to the brain: A critical reassessment
- (2014) Pericles Calias et al. PHARMACOLOGY & THERAPEUTICS
- The Influence of Body Position on Cerebrospinal Fluid Pressure Gradient and Movement in Cats with Normal and Impaired Craniospinal Communication
- (2014) Marijan Klarica et al. PLoS One
- Recombinant human tripeptidyl peptidase-1 infusion to the monkey CNS: Safety, pharmacokinetics, and distribution
- (2014) Brian R. Vuillemenot et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Drowning stars: reassessing the role of astrocytes in brain edema
- (2014) Alexander S. Thrane et al. TRENDS IN NEUROSCIENCES
- A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain (December2013)
- (2014) Hongbin Han et al. IEEE Journal of Biomedical and Health Informatics
- Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates
- (2013) S J Gray et al. GENE THERAPY
- Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery into the Cerebrospinal Fluid of Nonhuman Primates
- (2013) Lluis Samaranch et al. HUMAN GENE THERAPY
- Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
- (2013) Jeffrey J. Iliff et al. JOURNAL OF CLINICAL INVESTIGATION
- Pulsatility in CSF dynamics: pathophysiology of idiopathic normal pressure hydrocephalus
- (2013) S. Qvarlander et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain
- (2013) J. J. Iliff et al. JOURNAL OF NEUROSCIENCE
- The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in Development, Disease, and Therapy
- (2013) M. K. Lehtinen et al. JOURNAL OF NEUROSCIENCE
- Pig lumbar spine anatomy and imaging-guided lateral lumbar puncture: A new large animal model for intrathecal drug delivery
- (2013) Josef Pleticha et al. JOURNAL OF NEUROSCIENCE METHODS
- Utility of CSF in translational neuroscience
- (2013) Elizabeth C. M. de Lange JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid
- (2013) Joost Westerhout et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS
- (2013) Mikhail I. Papisov et al. MOLECULAR PHARMACEUTICS
- Diffusion of Macromolecules in the Brain: Implications for Drug Delivery
- (2013) Daniel J. Wolak et al. MOLECULAR PHARMACEUTICS
- Inhibition of aquaporin-4 significantly increases regional cerebral blood flow
- (2013) Hironaka Igarashi et al. NEUROREPORT
- Real-time magnetic resonance imaging visualization and quantitative assessment of diffusion in the cerebral extracellular space of C6 glioma-bearing rats
- (2013) Kai Li et al. NEUROSCIENCE LETTERS
- Cerebrospinal Fluid Secretion by the Choroid Plexus
- (2013) Helle H. Damkier et al. PHYSIOLOGICAL REVIEWS
- Sleep Drives Metabolite Clearance from the Adult Brain
- (2013) L. Xie et al. SCIENCE
- Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
- (2013) Sarah L. DeVos et al. Jove-Journal of Visualized Experiments
- Pilot study assessing a seven-day continuous intrathecal topotecan infusion for recurrent or progressive leptomeningeal metastatic cancer
- (2013) Hung C Tran et al. JOURNAL OF ONCOLOGY PHARMACY PRACTICE
- Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats
- (2012) Joost Westerhout et al. AAPS Journal
- Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma
- (2012) J. L. Rubenstein et al. BLOOD
- Development of a Physiologically Based Pharmacokinetic Model for the Rat Central Nervous System and Determination of an In Vitro–In Vivo Scaling Methodology for the Blood–Brain Barrier Permeability of Two Transporter Substrates, Morphine and Oxycodone
- (2012) Kathryn Ball et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Investigation of the Role of FcγR and FcRn in mAb Distribution to the Brain
- (2012) Lubna Abuqayyas et al. MOLECULAR PHARMACEUTICS
- Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment
- (2012) M.D. Howell et al. NEUROSCIENCE
- A phase-1 pharmacokinetic optimal dosing study of intraventricular topotecan for children with neoplastic meningitis: A pediatric brain tumor consortium study
- (2012) Susan M. Blaney et al. PEDIATRIC BLOOD & CANCER
- CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder
- (2012) Pericles Calias et al. PLoS One
- An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain
- (2012) HongBin Han et al. Science China-Life Sciences
- A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue
- (2012) E. A. Nance et al. Science Translational Medicine
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid
- (2012) J. J. Iliff et al. Science Translational Medicine
- SOD1 in Cerebral Spinal Fluid as a Pharmacodynamic Marker for Antisense Oligonucleotide Therapy
- (2012) Leah Winer et al. JAMA Neurology
- Delivery of proteins to CNS as seen and measured by positron emission tomography
- (2012) Mikhail I. Papisov et al. Drug Delivery and Translational Research
- Safety Assessment and Pharmacokinetics of Intrathecal Methylprednisolone Acetate in Dogs
- (2011) Mienke Rijsdijk et al. ANESTHESIOLOGY
- The blood-spinal cord barrier: Morphology and Clinical Implications
- (2011) Viktor Bartanusz et al. ANNALS OF NEUROLOGY
- Aquaporins in Clinical Medicine
- (2011) A.S. Verkman Annual Review of Medicine
- Astrocytes and pericytes cooperatively maintain a capillary-like structure composed of endothelial cells on gel matrix
- (2011) Yoshiaki Itoh et al. BRAIN RESEARCH
- Classification of hydrocephalus: critical analysis of classification categories and advantages of “Multi-categorical Hydrocephalus Classification” (Mc HC)
- (2011) Shizuo Oi CHILDS NERVOUS SYSTEM
- Overview of post-infective hydrocephalus
- (2011) Sandip Chatterjee et al. CHILDS NERVOUS SYSTEM
- A consensus on the classification of hydrocephalus: its utility in the assessment of abnormalities of cerebrospinal fluid dynamics
- (2011) Harold L. Rekate CHILDS NERVOUS SYSTEM
- Ventricle wall movements and cerebrospinal fluid flow in hydrocephalus
- (2011) Richard D. Penn et al. JOURNAL OF NEUROSURGERY
- Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
- (2011) Dhaval K. Shah et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Quantification of Gd-DTPA concentration in neuroimaging using T1 3D MP-RAGE sequence at 3.0 T
- (2011) Fangjingwei Xu et al. MAGNETIC RESONANCE IMAGING
- Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
- (2011) N. N. Haj-Yasein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Imaging biomarkers in Parkinson's disease
- (2011) David J. Brooks et al. PROGRESS IN NEUROBIOLOGY
- Staging Alzheimer's disease progression with multimodality neuroimaging
- (2011) Michael Ewers et al. PROGRESS IN NEUROBIOLOGY
- Development of hydrocephalus and classical hypothesis of cerebrospinal fluid hydrodynamics: Facts and illusions
- (2011) D. Orešković et al. PROGRESS IN NEUROBIOLOGY
- A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid- Production in Vivo
- (2011) J. K. Atwal et al. Science Translational Medicine
- Safety Evaluation of Chronic Intrathecal Administration of Idursulfase-IT in Cynomolgus Monkeys
- (2011) Brian R. Felice et al. TOXICOLOGIC PATHOLOGY
- Anatomy and physiology of cerebrospinal fluid
- (2011) L. Sakka et al. European Annals of Otorhinolaryngology-Head and Neck Diseases
- Safety and Pharmacokinetics of Single Intravenous Dose of MGAWN1, a Novel Monoclonal Antibody to West Nile Virus
- (2010) J. H. Beigel et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics
- (2010) C. Andrew Boswell et al. BIOCONJUGATE CHEMISTRY
- The formation of cerebrospinal fluid: Nearly a hundred years of interpretations and misinterpretations
- (2010) D. Orešković et al. BRAIN RESEARCH REVIEWS
- Recent insights into a new hydrodynamics of the cerebrospinal fluid
- (2010) Marin Bulat et al. BRAIN RESEARCH REVIEWS
- Safety and Changes in Plasma and Cerebrospinal Fluid Amyloid β After a Single Administration of an Amyloid β Monoclonal Antibody in Subjects With Alzheimer Disease
- (2010) Eric R. Siemers et al. CLINICAL NEUROPHARMACOLOGY
- A 4-Week Intrathecal Toxicity and Pharmacokinetic Study With Trastuzumab in Cynomolgus Monkeys
- (2010) Angélique P. J. M. Braen et al. INTERNATIONAL JOURNAL OF TOXICOLOGY
- Cilia Organize Ependymal Planar Polarity
- (2010) Z. Mirzadeh et al. JOURNAL OF NEUROSCIENCE
- Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs
- (2010) Andreas Kuttler et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Extracellular Matrix: Functions in the Nervous System
- (2010) C. S. Barros et al. Cold Spring Harbor Perspectives in Biology
- Investigation of the Influence of FcRn on the Distribution of IgG to the Brain
- (2009) Amit Garg et al. AAPS Journal
- A mathematical model of blood, cerebrospinal fluid and brain dynamics
- (2009) Andreas A. Linninger et al. JOURNAL OF MATHEMATICAL BIOLOGY
- Continuous intraventricular infusion of pentosan polysulfate: Clinical trial against prion diseases
- (2009) Yoshio Tsuboi et al. NEUROPATHOLOGY
- Intracerebroventricular Administration of Drugs
- (2009) Aaron M Cook et al. PHARMACOTHERAPY
- The rotational model and microdialysis: Significance for dopamine signalling, clinical studies, and beyond
- (2009) Mario Herrera-Marschitz et al. PROGRESS IN NEUROBIOLOGY
- The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction
- (2009) Britta Engelhardt et al. Seminars in Immunopathology
- Lymphatic drainage of the brain and the pathophysiology of neurological disease
- (2008) Roy O. Weller et al. ACTA NEUROPATHOLOGICA
- Intrathecal enzyme replacement therapy in a patient with mucopolysaccharidosis type I and symptomatic spinal cord compression
- (2008) Maria-Veronica Munoz-Rojas et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Diffusion of Flexible Random-Coil Dextran Polymers Measured in Anisotropic Brain Extracellular Space by Integrative Optical Imaging
- (2008) Fanrong Xiao et al. BIOPHYSICAL JOURNAL
- Feasibility and safety of intrathecal nimodipine on posthaemorrhagic cerebral vasospasm refractory to medical and endovascular therapy
- (2008) Daniel Hänggi et al. CLINICAL NEUROLOGY AND NEUROSURGERY
- CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective
- (2008) Jiunn Lin CURRENT DRUG METABOLISM
- Recurrent lymphomatous meningitis treated with intra-CSF rituximab and liposomal ara-C
- (2008) Marc C. Chamberlain et al. JOURNAL OF NEURO-ONCOLOGY
- High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl/6J mice
- (2008) A.E. Dorr et al. NEUROIMAGE
- Diffusion in Brain Extracellular Space
- (2008) Eva Syková et al. PHYSIOLOGICAL REVIEWS
- In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate
- (2008) R. G. Thorne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain
- (2007) Zsolt Zador et al. FASEB JOURNAL
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