Targeting nanoparticles to the brain by exploiting the blood–brain barrier impermeability to selectively label the brain endothelium

A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

(2020) Mark F Sabbagh et al.   eLife

A ligand motif enables differential vascular targeting of endothelial junctions between brain and retina

(2019) Fenny H. F. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury

(2019) Evan M. Lutton et al.   Frontiers in Neurology

Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide

(2019) Lin-Ping Wu et al.   Nature Communications

Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice

(2018) Linhao You et al.   ACS Nano

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

(2018) Fred C. Lam et al.   Nature Communications

The Role of the Blood Brain Barrier in Neurodegenerative Disorders and their Treatment

(2018) Alan M. Palmer   JOURNAL OF ALZHEIMERS DISEASE

L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted nano-vehicles

(2018) Daniel Gonzalez-Carter et al.   Nanomedicine-Nanotechnology Biology and Medicine

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake

(2018) Hamideh Parhiz et al.   JOURNAL OF CONTROLLED RELEASE

Nanoscale manipulation of membrane curvature for probing endocytosis in live cells

(2017) Wenting Zhao et al.   Nature Nanotechnology

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

(2017) Y. Anraku et al.   Nature Communications

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

(2017) Kasper Bendix Johnsen et al.   Scientific Reports

Large amino acid transporter 1 mediated glutamate modified docetaxel-loaded liposomes for glioma targeting

(2016) Lin Li et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke

(2015) Qi-jin Yu et al.   Neural Regeneration Research

A Role for Low Density Lipoprotein Receptor-Related Protein 1 in the Cellular Uptake of Tissue Plasminogen Activator in the Lungs

(2015) Swan Lin et al.   PHARMACEUTICAL RESEARCH

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

(2015) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP-1-mediated intracellular antibody delivery to the Central Nervous System

(2015) Xiaohe Tian et al.   Scientific Reports

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

(2015) Anita Ramanathan et al.   Frontiers in Aging Neuroscience

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Nitrosation-Dependent Caveolin 1 Phosphorylation, Ubiquitination, and Degradation and its Association with Idiopathic Pulmonary Arterial Hypertension

(2014) Farnaz R. Bakhshi et al.   Pulmonary Circulation

PECAM-1 and caveolae form the mechanosensing complex necessary for NOX2 activation and angiogenic signaling with stopped flow in pulmonary endothelium

(2013) John Noel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Choline transporter-targeting and co-delivery system for glioma therapy

(2013) Jianfeng Li et al.   BIOMATERIALS

Binding, Transcytosis and Biodistribution of Anti-PECAM-1 Iron Oxide Nanoparticles for Brain-Targeted Delivery

(2013) Mo Dan et al.   PLoS One

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

(2013) D. T. Wiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Choline-Derivate-Modified Nanoparticles for Brain-Targeting Gene Delivery

(2011) Jianfeng Li et al.   ADVANCED MATERIALS

Caveolin-1 opens endothelial cell junctions by targeting catenins

(2011) Romy Kronstein et al.   CARDIOVASCULAR RESEARCH

Efficient In Vivo Delivery of siRNA Into Brain Capillary Endothelial Cells Along With Endogenous Lipoprotein

(2011) Hiroya Kuwahara et al.   MOLECULAR THERAPY

Local clustering of transferrin receptors promotes clathrin-coated pit initiation

(2010) Allen P. Liu et al.   JOURNAL OF CELL BIOLOGY

Inflammation Determines the Pro-Adhesive Properties of High Extracellular D-Glucose in Human Endothelial Cells In Vitro and Rat Microvessels In Vivo

(2010) Verónica Azcutia et al.   PLoS One

Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

(2009) Yong Hong Chen et al.   NATURE MEDICINE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE