Multifaceted interactions between adaptive immunity and the central nervous system

Reflexes in Immunity

(2016) Kevin J. Tracey   CELL

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Targeting Neural Circuits

(2016) Priyamvada Rajasethupathy et al.   CELL

Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs

(2016) Ekaterina Petrovich et al.   FASEB JOURNAL

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Genetically targeted magnetic control of the nervous system

(2016) Michael A Wheeler et al.   NATURE NEUROSCIENCE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

(2015) Catherine Larochelle et al.   ANNALS OF NEUROLOGY

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

(2015) Mauricio F. Farez et al.   CELL

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Neural circuitry and immunity

(2015) Valentin A. Pavlov et al.   IMMUNOLOGIC RESEARCH

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Dealing with Danger in the CNS: The Response of the Immune System to Injury

(2015) Sachin P. Gadani et al.   NEURON

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

Glial regulation of the blood-brain barrier in health and disease

(2015) Bieke Broux et al.   Seminars in Immunopathology

GM-CSF in Neuroinflammation: Licensing Myeloid Cells for Tissue Damage

(2015) Andrew L. Croxford et al.   TRENDS IN IMMUNOLOGY

Immune Surveillance of the CNS following Infection and Injury

(2015) Matthew V. Russo et al.   TRENDS IN IMMUNOLOGY

Precision medicine in chronic disease management: The multiple sclerosis BioScreen

(2014) Pierre-Antoine Gourraud et al.   ANNALS OF NEUROLOGY

Immunology of Relapse and Remission in Multiple Sclerosis

(2014) Lawrence Steinman   Annual Review of Immunology

Development of the mammalian lymphatic vasculature

(2014) Ying Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory T Cells in Central Nervous System Injury: A Double-Edged Sword

(2014) James T. Walsh et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

(2014) Benoit Aubé et al.   JOURNAL OF IMMUNOLOGY

Synapse elimination and learning rules co-regulated by MHC class I H2-Db

(2014) Hanmi Lee et al.   NATURE

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

(2013) Ali Radjavi et al.   BRAIN BEHAVIOR AND IMMUNITY

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39

(2013) Ivan D Mascanfroni et al.   NATURE IMMUNOLOGY

Mice Infected with Low-Virulence Strains of Toxoplasma gondii Lose Their Innate Aversion to Cat Urine, Even after Extensive Parasite Clearance

(2013) Wendy Marie Ingram et al.   PLoS One

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Modeling the heterogeneity of multiple sclerosis in animals

(2013) Sarah B. Simmons et al.   TRENDS IN IMMUNOLOGY

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

(2012) Christian A. von Hehn et al.   NEURON

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?

(2009) Howard L. Weiner   ANNALS OF NEUROLOGY

Immune and Nervous Systems: More Than Just a Superficial Similarity?

(2009) Dimitris Kioussis et al.   IMMUNITY

Classical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity

(2009) Akash Datwani et al.   NEURON

MHC Class I: An Unexpected Role in Neuronal Plasticity

(2009) Carla J. Shatz   NEURON

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Adaptive immunity affects learning behavior in mice

(2008) Anna Brynskikh et al.   BRAIN BEHAVIOR AND IMMUNITY

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration

(2008) J. K. Atwal et al.   SCIENCE

Immunity and cognition: what do age-related dementia, HIV-dementia and ‘chemo-brain’ have in common?

(2008) Jonathan Kipnis et al.   TRENDS IN IMMUNOLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE