Article
Chemistry, Multidisciplinary
Weizhi Chen, Yang Yuan, Cheng Li, Hui Mao, Baorui Liu, Xiqun Jiang
Summary: This study reveals that blocking cancer cell signaling can disrupt tumor extracellular matrix, and it is demonstrated that multireceptor-mediated modulation of tumor ECM can reverse tumor microenvironment remodeling. These findings are not only important for understanding the regulatory role of cancer cells in tumor microenvironment development, but also introduce a new therapeutic platform or strategy for cancer treatment.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Katie J. Hogan, Marissa R. Perez, Antonios G. Mikos
Summary: The extracellular matrix (ECM) is composed of various proteins, proteoglycans, and biomolecules. ECM-based materials have shown great potential in drug delivery and tissue engineering applications due to their high biocompatibility and bioactivity. This review focuses on nanoparticles incorporating ECM-based materials and their applications in drug delivery and tissue engineering, highlighting the use of proteins (gelatin, collagen, fibrin) and glycosaminoglycans (hyaluronic acid, chondroitin sulfate, heparin) for cancer therapy, gene delivery, wound healing, and regenerative medicine. Modification and functionalization of these materials with synthetic and natural polymers, as well as stimuli-responsive degradation and drug release strategies, have improved their efficacy and allowed for targeted drug delivery and tissue-specific cell differentiation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Nithya Subrahmanyam, Bhuvanesh Yathavan, Julian Kessler, Hamidreza Ghandehari
Summary: The extracellular matrix (ECM) plays an important role in cell growth and cancer etiology. Tumor-associated ECM has high collagen deposition and remodeling activity. A study developed polymeric carriers that selectively bind to denatured collagen in tumor ECM, which can be used for the management of diseases characterized by high ECM remodeling activity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Health Care Sciences & Services
Nithya Subrahmanyam, Hamidreza Ghandehari
Summary: The extracellular matrix (ECM) is actively involved in cancer progression and presents opportunities for cancer therapy through its interactions with signaling molecules and cells. By targeting the ECM, interventions can be made in the invasiveness of tumors and in facilitating drug delivery for therapeutic purposes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Ji-Sun Kim, Jam-Eon Park, Seung-Hyeon Choi, Se Won Kang, Ju Huck Lee, Jung-Sook Lee, Minsang Shin, Seung-Hwan Park
Summary: Bacterial cancer therapies aim to use engineered bacteria to deliver cytotoxic drugs to tumors, either triggering an immune response or increasing antitumor efficacy when combined with chemotherapeutic drugs. By degrading the extracellular matrix (ECM) surrounding cancer cells, bacteria can effectively suppress tumor growth and prolong survival when combined with chemotherapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, Research & Experimental
Nithya Subrahmanyam, Bhuvanesh Yathavan, S. Michael Yu, Hamidreza Ghandehari
Summary: Osteosarcoma (OS) is the most common malignant bone cancer in adolescents. Chemotherapeutic treatment for OS is limited by off target toxicities and lacks sufficient localization at the tumor site. In this study, collagen hybridizing peptides (CHPs) were conjugated with water-soluble HPMA copolymers to target OS tumors. The results showed increased accumulation and retention of the targeted copolymers compared to non-targeted copolymers and CHPs, providing a foundation for the use of HPMA copolymer-CHP conjugates as targeted drug delivery systems in OS tumors.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Sumel Ashique, Krishnan Anand
Summary: Extracellular vesicles (ECVs) have been abandoned as bio-inspired drug delivery systems (DDS) in the biomedical field. ECVs have a natural ability to cross over extracellular and intracellular barriers, making them superior to manufactured nanoparticles. Additionally, they have the ability to move beneficial biomolecules among far-flung bodily cells. These advantages and the accomplishment of favorable in vivo results convincingly show the value of ECVs in medication delivery. The usage of ECVs is constantly being improved, as it might be difficult to develop a consistent biochemical strategy that is in line with their useful clinical therapeutic uses.
Review
Engineering, Biomedical
Xiaoxuan Xu, Yao Wu, Xindi Qian, Yuqi Wang, Jiaoying Wang, Jie Li, Yaping Li, Zhiwen Zhang
Summary: By regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM, intratumor ECM barriers can be effectively overcome, leading to improved drug delivery and anticancer efficacy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Oncology
Akhil Srivastava, Shipra Rathore, Anupama Munshi, Rajagopal Ramesh
Summary: Exosomes, as a natural form of cell communication, have potential applications as drug delivery vehicles and in cancer treatment. However, challenges such as sourcing and scaling up production need to be addressed for broader use.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Agata Noelia Traverso, David Jose Fragale, Diego Luis Viale, Octavio Garate, Pablo Torres, Gaston Valverde, Alejandro Berra, Ana Vanesa Torbidoni, Juan Sebastian Yakisich, Mariano Grasselli, Martin Radrizzani
Summary: In this study, a two-step procedure for preparing biohybrid nanoparticles with a hydrophobic quantum dot core and a multilayer coating of human serum albumin is reported. These nanoparticles, decorated with proteins like human serum albumin or human transferrin, retained their fluorescent properties and showed no corona effect in the presence of serum. They were selectively taken up by lung cancer and neuroblastoma cells but not by non-cancerous cells or differentiated neurons. Moreover, digitoxin-loaded transferrin-decorated nanoparticles specifically reduced the number of lung cancer cells. Finally, the in vivo uptake of these biohybrid nanoparticles by retinal cells in mice demonstrated their excellent targeting and traceability.
Review
Polymer Science
Julian A. Serna, Laura Rueda-Gensini, Daniela N. Cespedes-Valenzuela, Javier Cifuentes, Juan C. Cruz, Carolina Munoz-Camargo
Summary: Hydrogels play a vital role in biomedical applications, with dECM-derived hydrogels offering high biomimetic capabilities that can be enhanced through external stimuli for tissue engineering and regenerative medicine advancements.
Article
Neurosciences
Ichiro Takashima, Riichi Kajiwara
Summary: Functional magnetic resonance imaging studies assume linear relationships between hemodynamic responses and neural activity, but investigating the neurovascular transfer function accurately requires full-field imaging of electrophysiological and hemodynamic responses with optical imaging tools like VSD and IS. Results from optical imaging in rat somatosensory cortices showed differences in sensory responses between S1 and S2, with more localized neural activity in S1 and stronger metabolic responses in S1 compared to S2. Despite these differences, the neurovascular coupling did not vary between the S1 and S2 cortices.
Article
Biochemistry & Molecular Biology
Lidia Gomez-Cid, Maria Luisa Lopez-Donaire, Diego Velasco, Victor Marin, Maria Isabel Gonzalez, Beatriz Salinas, Lorena Cusso, Angel Garcia, Susana Belen Bravo, Maria Eugenia Fernandez-Santos, Carlos Elvira, Johanna Sierra, Ester Arroba, Rafael Banares, Lilian Grigorian-Shamagian, Francisco Fernandez-Aviles
Summary: Stem cell-derived extracellular vesicles (EVs) show beneficial effects in preclinical models of cardiac diseases, but their poor retention at the target site limits their efficacy. A new product combining cardiac extracellular matrix hydrogels (cECMH), polyethylene glycol (PEG), and EVs (EVs-PEG-cECMH) was developed to overcome this limitation. The combined product demonstrated improved physicochemical properties, increased on-site retention, and maintained bioactivity, potentially leading to enhanced therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Jie Zhang, Ziqing Xu, Yang Li, Yongzhi Hu, Jiajia Tang, Jiaqi Xu, Yafei Luo, Feiyun Wu, Xiaolian Sun, Yuxia Tang, Shouju Wang
Summary: In this study, a theranostic nanoplatform was designed to remodel the extracellular matrix (ECM) in breast cancer through combination treatment. The platform effectively loaded Halofuginone (HF) and enhanced anti-cancer efficacy through photothermal therapy and anti-TGF beta effect.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Xudong Zhang, Qianming Li, Zhengxi Wang, Wei Zhou, Linlin Zhang, Yingsheng Liu, Ze Xu, Zheng Li, Chen Zhu, Xianzuo Zhang
Summary: This study comprehensively assessed the existing research and recent progress on bone regeneration materials (BRMs) and explored potential future directions. Through literature review and data mining analysis, it was found that China, the United States, and Italy were the most productive countries. Acta Biomaterialia and Biomaterials were the most prolific journals in the BRM field. Recent research focused on extracellular matrices, hydrogel materials, and drug delivery systems. The research hotspots included growth factors, bone morphogenetic protein-2, and mesenchymal stem cells. Future relevant research fields will focus on composite scaffolds, 3D printing technology, and antibacterial activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
News Item
Biophysics
Charles Nicholson
BIOPHYSICAL JOURNAL
(2015)
Review
Clinical Neurology
Jenna M. Tarasoff-Conway, Roxana O. Carare, Ricardo S. Osorio, Lidia Glodzik, Tracy Butler, Els Fieremans, Leon Axel, Henry Rusinek, Charles Nicholson, Berislav V. Zlokovic, Blas Frangione, Kaj Blennow, Joel Menard, Henrik Zetterberg, Thomas Wisniewski, Mony J. de Leon
NATURE REVIEWS NEUROLOGY
(2015)
Correction
Clinical Neurology
Jenna M. Tarasoff-Conway, Roxana O. Carare, Ricardo S. Osorio, Lidia Glodzik, Tracy Butler, Els Fieremans, Leon Axel, Henry Rusinek, Charles Nicholson, Berislav V. Zlokovic, Blas Frangione, Kaj Blennow, Joel Menard, Henrik Zetterberg, Thomas Wisniewski, Mony J. de Leon
NATURE REVIEWS NEUROLOGY
(2016)
Article
Multidisciplinary Sciences
John Odackal, Robert Colbourn, Namrita Jain Odackal, Lian Tao, Charles Nicholson, Sabina Hrabetova
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Neurosciences
Jyoti C. Patel, Melissa A. Stouffer, Maria Mancini, Charles Nicholson, Kenneth D. Carr, Margaret E. Rice
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Gayatri Venkiteswaran, Stephen W. Lewellis, John Wang, Eric Reynolds, Charles Nicholson, Holger Knaut
Article
Neurosciences
Xianting Li, Jyoti C. Patel, Jing Wang, Marat V. Avshalumov, Charles Nicholson, Joseph D. Buxbaum, Gregory A. Elder, Margaret E. Rice, Zhenyu Yue
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Sabina Hrabetova, Daniel Masri, Lian Tao, Fanrong Xiao, Charles Nicholson
JOURNAL OF PHYSIOLOGY-LONDON
(2009)
Article
Multidisciplinary Sciences
Lulu Xie, Hongyi Kang, Qiwu Xu, Michael J. Chen, Yonghong Liao, Meenakshisundaram Thiyagarajan, John O'Donnell, Daniel J. Christensen, Charles Nicholson, Jeffrey J. Iliff, Takahiro Takano, Rashid Deane, Maiken Nedergaard
Article
Biochemistry & Molecular Biology
Charles Nicholson, Padideh Kamali-Zare
NEUROCHEMICAL RESEARCH
(2020)
Editorial Material
Biochemistry & Molecular Biology
N. Joan Abbott, Charles Nicholson, Alexei Verkhratsky
NEUROCHEMICAL RESEARCH
(2020)
Article
Neurosciences
Robert Colbourn, Jan Hrabe, Charles Nicholson, Matthew Perkins, Jeffrey H. Goodman, Sabina Hrabetova
Summary: The discovery of rapid volume pulsation (RVP) during epileptic seizures suggests a potential novel target for epilepsy management and treatment, as RVP is closely associated with epileptiform activity across multiple models. Pharmacological blockade of the electrogenic Na+/HCO3- cotransporter by DIDS was effective in halting both RVP and epileptiform activity, demonstrating its importance in epilepsy treatment.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biophysics
Charles Nicholson, Sabina Hrabetova
BIOPHYSICAL JOURNAL
(2017)
Review
Neurosciences
Adam Chodobski, Jean-Francois Ghersi-Egea, Charles Nicholson, Tavarekere Nagaraja, Joanna Szmydynger-Chodobska
FLUIDS AND BARRIERS OF THE CNS
(2015)
Article
Mathematics, Interdisciplinary Applications
Charles Nicholson, Padideh Kamali-Zare, Lian Tao
COMPUTING AND VISUALIZATION IN SCIENCE
(2011)