Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

(2016) Erik N. T. P. Bakker et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways

(2016) Beatrice Bedussi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Diffusion of macromolecules in a polymer hydrogel: from microscopic to macroscopic scales

(2016) D. Sandrin et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

An assessment of the ability of the obstruction-scaling model to estimate solute diffusion coefficients in hydrogels

(2015) Nicholas A. Hadjiev et al.   JOURNAL OF CONTROLLED RELEASE

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Muddying the water in brain edema?

(2015) Alex J. Smith et al.   TRENDS IN NEUROSCIENCES

How astrocyte networks may contribute to cerebral metabolite clearance

(2015) Mahdi Asgari et al.   Scientific Reports

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

(2015) Natalya Korogod et al.   eLife

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Drowning stars: reassessing the role of astrocytes in brain edema

(2014) Alexander S. Thrane et al.   TRENDS IN NEUROSCIENCES

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Diffusion in the extracellular space in brain and tumors

(2013) A S Verkman   PHYSICAL BIOLOGY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation

(2012) Esther Steiner et al.   GLIA

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Real-Time Imaging of Perivascular Transport of Nanoparticles During Convection-Enhanced Delivery in the Rat Cortex

(2011) Conor P. Foley et al.   ANNALS OF BIOMEDICAL ENGINEERING

Microfiberoptic Measurement of Extracellular Space Volume in Brain and Tumor Slices Based on Fluorescent Dye Partitioning

(2010) Hua Zhang et al.   BIOPHYSICAL JOURNAL

Improved Model of Fluorescence Recovery Expands the Application of Multiphoton Fluorescence Recovery after Photobleaching in Vivo

(2009) Kelley D. Sullivan et al.   BIOPHYSICAL JOURNAL

Electrostatic and electrokinetic effects on hindered convection in pores

(2009) Panadda Dechadilok et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

A New FRAP/FRAPa Method for Three-Dimensional Diffusion Measurements Based on Multiphoton Excitation Microscopy

(2008) Davide Mazza et al.   BIOPHYSICAL JOURNAL

Real-time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices andin vivorevealed by two-photon microscopy

(2008) W. Christopher Risher et al.   GLIA

Extracellular Diffusion Parameters in the Rat Somatosensory Cortex during Recovery from Transient Global Ischemia/Hypoxia

(2008) Norbert Zoremba et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aquaporin-4-Deficient Mice Have Increased Extracellular Space without Tortuosity Change

(2008) X. Yao et al.   JOURNAL OF NEUROSCIENCE

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS