Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
出版年份 2020 全文链接
标题
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
作者
关键词
type 2 diabetes, lipoglucotoxicity, glucolipotoxicity, human pancreatic islets, beta cells, damage, recovery, endoplasmic reticulum stress, transcriptome, eQTL
出版物
Cell Reports
Volume 33, Issue 9, Pages 108466
出版商
Elsevier BV
发表日期
2020-12-01
DOI
10.1016/j.celrep.2020.108466
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
- (2020) Décio L. Eizirik et al. Nature Reviews Endocrinology
- A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes
- (2020) Piero Marchetti et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Loss of the transcription factor MAFB limits β-cell derivation from human PSCs
- (2020) Ronan Russell et al. Nature Communications
- Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
- (2020) Ana Viñuela et al. Nature Communications
- Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes
- (2019) Amna Khamis et al. Molecular Metabolism
- Brain mitochondrial proteome alteration driven by creatine deficiency suggests novel therapeutic venues for creatine deficiency syndromes
- (2019) Laura Giusti et al. NEUROSCIENCE
- g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
- (2019) Uku Raudvere et al. NUCLEIC ACIDS RESEARCH
- Understanding the mechanisms of reversal of type 2 diabetes
- (2019) Roy Taylor et al. Lancet Diabetes & Endocrinology
- Fostering improved human islet research: a European perspective
- (2019) Piero Marchetti et al. DIABETOLOGIA
- Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis
- (2019) Damiana Pieragostino et al. Journal of Proteomics
- Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
- (2019) Irene Miguel-Escalada et al. NATURE GENETICS
- Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets
- (2019) Elin Hall et al. DIABETES
- Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes
- (2019) Maria Lytrivi et al. JOURNAL OF MOLECULAR BIOLOGY
- A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression
- (2018) Ina Kycia et al. AMERICAN JOURNAL OF HUMAN GENETICS
- IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells
- (2018) Alexandra Coomans de Brachène et al. DIABETOLOGIA
- Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial
- (2018) Michael EJ Lean et al. LANCET
- Proteomic Characterization of a New asymmetric Cellulose Triacetate Membrane for Hemodialysis
- (2018) Maurizio Ronci et al. Proteomics Clinical Applications
- Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach
- (2018) Kelly M. Cahill et al. Scientific Reports
- Type 2 diabetes in adolescents and young adults
- (2018) Nadia Lascar et al. Lancet Diabetes & Endocrinology
- Modeling human pancreatic beta cell dedifferentiation
- (2018) Marc Diedisheim et al. Molecular Metabolism
- Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery
- (2018) Roy Taylor et al. Cell Metabolism
- Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?
- (2018) Maria Lytrivi et al. CURRENT OPINION IN PHARMACOLOGY
- Immune cell gene signatures for profiling the microenvironment of solid tumors
- (2018) Ajit J Nirmal et al. Cancer Immunology Research
- Transient neonatal diabetes mellitus and hypomethylation at additional imprinted loci: novel ZFP57 mutation and review on the literature
- (2018) Ameni Touati et al. ACTA DIABETOLOGICA
- Single-Cell RNA-Seq of the Pancreatic Islets––a Promise Not yet Fulfilled?
- (2018) Yue J. Wang et al. Cell Metabolism
- A Call for Improved Reporting of Human Islet Characteristics in Research Articles
- (2018) Vincent Poitout et al. DIABETES
- Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions
- (2018) Nathaniel J. Hart et al. DIABETOLOGIA
- Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
- (2018) Melanie J. Davies et al. DIABETOLOGIA
- Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- (2018) Anubha Mahajan et al. NATURE GENETICS
- GENCODE reference annotation for the human and mouse genomes
- (2018) Adam Frankish et al. NUCLEIC ACIDS RESEARCH
- From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion
- (2018) Jin-Kui Yang et al. Cell Reports
- IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots
- (2017) David E Maridas et al. ENDOCRINOLOGY
- Islet inflammation in type 2 diabetes and physiology
- (2017) Kosei Eguchi et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions
- (2017) Mohammed Bensellam et al. JOURNAL OF ENDOCRINOLOGY
- Type 2 diabetes
- (2017) Sudesna Chatterjee et al. LANCET
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?
- (2017) Katleen Lemaire et al. PLoS One
- Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
- (2017) Arushi Varshney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene
- (2017) Timothy J. Pullen et al. Frontiers in Genetics
- Metabolic Stress and Compromised Identity of Pancreatic Beta Cells
- (2017) Avital Swisa et al. Frontiers in Genetics
- Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets
- (2017) Federica Ciregia et al. Scientific Reports
- Type 2 Diabetes: The Pathologic Basis of Reversible β-Cell Dysfunction
- (2016) Michael G. White et al. DIABETES CARE
- Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders
- (2016) Sarah Steven et al. DIABETES CARE
- When β-cells fail: lessons from dedifferentiation
- (2016) D. Accili et al. DIABETES OBESITY & METABOLISM
- Islet inflammation in type 2 diabetes
- (2016) Piero Marchetti DIABETOLOGIA
- HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use
- (2016) Anton E. Ludvik et al. ENDOCRINOLOGY
- Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
- (2016) Francesca Cinti et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- PAX6 maintains β cell identity by repressing genes of alternative islet cell types
- (2016) Avital Swisa et al. JOURNAL OF CLINICAL INVESTIGATION
- Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
- (2016) Chunhua Dai et al. JOURNAL OF CLINICAL INVESTIGATION
- The genetic architecture of type 2 diabetes
- (2016) Christian Fuchsberger et al. NATURE
- MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes
- (2016) Elvira Ganic et al. Cell Reports
- Islet β-cell failure in type 2 diabetes – Within the network of toxic lipids
- (2015) Justyna Janikiewicz et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Pancreatic β-cell identity, glucose sensing and the control of insulin secretion
- (2015) Guy A. Rutter et al. BIOCHEMICAL JOURNAL
- In vitro use of free fatty acids bound to albumin: A comparison of protocols
- (2015) Ana F Oliveira et al. BIOTECHNIQUES
- Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms
- (2015) Flora Brozzi et al. DIABETOLOGIA
- Bariatric–metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial
- (2015) Geltrude Mingrone et al. LANCET
- Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle
- (2015) Yoshiaki Shimoda et al. PLoS One
- AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages
- (2015) E Six et al. Cell Death & Disease
- Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci
- (2015) Martijn van de Bunt et al. PLoS Genetics
- LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia
- (2015) Gao Sun et al. Molecular Metabolism
- The Type 2 Diabetes Risk Allele of TMEM154-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes
- (2015) Marie Neergaard Harder et al. PLoS One
- Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets
- (2014) Elin Hall et al. BMC Medicine
- Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3
- (2014) A. B. Osipovich et al. DEVELOPMENT
- ADCY5 Couples Glucose to Insulin Secretion in Human Islets
- (2014) D. J. Hodson et al. DIABETES
- β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
- (2014) Philippe A. Halban et al. DIABETES CARE
- Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
- (2014) J. Fadista et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MYC and the Control of Apoptosis
- (2014) S. B. McMahon Cold Spring Harbor Perspectives in Medicine
- Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity
- (2013) Marc Y. Donath et al. Cell Metabolism
- RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
- (2013) Miriam Cnop et al. DIABETES
- Long-Term Effects of Bariatric Surgery on Meal Disposal and -Cell Function in Diabetic and Nondiabetic Patients
- (2013) S. Camastra et al. DIABETES
- Highly Sensitive Diagnosis of 43 Monogenic Forms of Diabetes or Obesity Through One-Step PCR-Based Enrichment in Combination With Next-Generation Sequencing
- (2013) A. Bonnefond et al. DIABETES CARE
- β-Cell inflammation in human type 2 diabetes and the role of autophagy
- (2013) L. Marselli et al. DIABETES OBESITY & METABOLISM
- BiallelicPDX1(insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency
- (2013) E. De Franco et al. DIABETIC MEDICINE
- Are we overestimating the loss of beta cells in type 2 diabetes?
- (2013) Lorella Marselli et al. DIABETOLOGIA
- Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome
- (2013) A. C. Nica et al. GENOME RESEARCH
- AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels
- (2013) Craig Beall et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Multidomain integration in the structure of the HNF-4α nuclear receptor complex
- (2013) Vikas Chandra et al. NATURE
- Persistent Overexpression of Phosphoglycerate Mutase, a Glycolytic Enzyme, Modifies Energy Metabolism and Reduces Stress Resistance of Heart in Mice
- (2013) Junji Okuda et al. PLoS One
- TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
- (2013) Daehwan Kim et al. GENOME BIOLOGY
- Short-term intensive insulin therapy in type 2 diabetes mellitus: a systematic review and meta-analysis
- (2013) Caroline Kaercher Kramer et al. Lancet Diabetes & Endocrinology
- Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
- (2012) Taro Hitosugi et al. CANCER CELL
- Diabetes Mellitus and the β Cell: The Last Ten Years
- (2012) Frances M. Ashcroft et al. CELL
- A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
- (2012) Jalal Taneera et al. Cell Metabolism
- Adaptive changes of human islets to an obesogenic environment in the mouse
- (2012) S. Gargani et al. DIABETOLOGIA
- Examining the Effects of Hyperglycemia on Pancreatic Endocrine Function in Humans: Evidence forin VivoGlucotoxicity
- (2012) Thomas P. J. Solomon et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- The MYC-Associated Protein CDCA7 Is Phosphorylated by AKT To Regulate MYC-Dependent Apoptosis and Transformation
- (2012) R. Montgomery Gill et al. MOLECULAR AND CELLULAR BIOLOGY
- The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions
- (2012) Mohammed Bensellam et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin–proteasome system in pancreatic beta cell dysfunction
- (2012) Marco Bugliani et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Role of AMPK in pancreatic beta cell function
- (2012) Accalia Fu et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation
- (2012) Davis J. McCarthy et al. NUCLEIC ACIDS RESEARCH
- The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis
- (2012) Qiman Sun et al. PLoS One
- Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet-Induced Glucose Intolerance
- (2011) M. C. Akerfeldt et al. DIABETES
- The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals
- (2011) N. Grarup et al. DIABETOLOGIA
- A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
- (2011) Philippe Ravassard et al. JOURNAL OF CLINICAL INVESTIGATION
- The Stunned β Cell: A Brief History
- (2010) Ele Ferrannini Cell Metabolism
- Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation
- (2010) L. Thorrez et al. GENOME RESEARCH
- Transcriptome genetics using second generation sequencing in a Caucasian population
- (2010) Stephen B. Montgomery et al. NATURE
- Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures
- (2010) Seema B. Plaisier et al. NUCLEIC ACIDS RESEARCH
- Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
- (2010) Lorella Marselli et al. PLoS One
- Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
- (2010) Daniele Merico et al. PLoS One
- Pathway analysis of dilated cardiomyopathy using global proteomic profiling and enrichment maps
- (2010) Ruth Isserlin et al. PROTEOMICS
- Identification of genes selectively disallowed in the pancreatic islet
- (2010) Timothy J. Pullen et al. Islets
- Glucolipotoxicity of the pancreatic beta cell
- (2009) Vincent Poitout et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Glioblastoma Proto-oncogene SEC61 Is Required for Tumor Cell Survival and Response to Endoplasmic Reticulum Stress
- (2009) Z. Lu et al. CANCER RESEARCH
- Linking Fatty Acid Stress to -Cell Mitochondrial Dynamics
- (2009) A. Wiederkehr et al. DIABETES
- Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
- (2009) Daniel A. Cunha et al. DIABETES
- Goals of Treatment for Type 2 Diabetes: -Cell preservation for glycemic control
- (2009) P. Marchetti et al. DIABETES CARE
- Towards better understanding of the contributions of overwork and glucotoxicity to the β-cell inadequacy of type 2 diabetes
- (2009) G. C. Weir et al. DIABETES OBESITY & METABOLISM
- Autophagy in human type 2 diabetes pancreatic beta cells
- (2009) M. Masini et al. DIABETOLOGIA
- β-Cell deterioration during diabetes: what's in the gun?
- (2009) R. Paul Robertson TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction
- (2008) Vincent Poitout et al. ENDOCRINE REVIEWS
- Initiation and execution of lipotoxic ER stress in pancreatic -cells
- (2008) D. A. Cunha et al. JOURNAL OF CELL SCIENCE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started