标题
The genetic architecture of type 2 diabetes
作者
关键词
-
出版物
NATURE
Volume 536, Issue 7614, Pages 41-47
出版商
Springer Nature
发表日期
2016-07-12
DOI
10.1038/nature18642
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
- (2015) Kyle J Gaulton et al. NATURE GENETICS
- The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium
- (2015) Gonneke Willemsen et al. Twin Research and Human Genetics
- Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits
- (2014) Joseph K. Pickrell AMERICAN JOURNAL OF HUMAN GENETICS
- minimac2: faster genotype imputation
- (2014) Christian Fuchsberger et al. BIOINFORMATICS
- Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms
- (2014) Melina Claussnitzer et al. CELL
- Association of a Low-Frequency Variant inHNF1AWith Type 2 Diabetes in a Latino Population
- (2014) Karol Estrada et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- A polygenic burden of rare disruptive mutations in schizophrenia
- (2014) Shaun M. Purcell et al. NATURE
- A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
- (2014) Ida Moltke et al. NATURE
- Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
- (2014) Valgerdur Steinthorsdottir et al. NATURE GENETICS
- Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
- (2014) Lorenzo Pasquali et al. NATURE GENETICS
- Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
- (2014) Jason Flannick et al. NATURE GENETICS
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
- (2014) Anubha Mahajan et al. NATURE GENETICS
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content
- (2014) H. Mahdessian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
- (2014) A. R. Majithia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies
- (2013) Seunggeun Lee et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Whole-Exome Sequencing of 2,000 Danish Individuals and the Role of Rare Coding Variants in Type 2 Diabetes
- (2013) Kirk E. Lohmueller et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4
- (2013) R. C. W. Ma et al. DIABETOLOGIA
- Recommended Joint and Meta-Analysis Strategies for Case-Control Association Testing of Single Low-Count Variants
- (2013) Clement Ma et al. GENETIC EPIDEMIOLOGY
- Evaluating empirical bounds on complex disease genetic architecture
- (2013) Vineeta Agarwala et al. NATURE GENETICS
- Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
- (2013) S. C. J. Parker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- Detecting and Estimating Contamination of Human DNA Samples in Sequencing and Array-Based Genotype Data
- (2012) Goo Jun et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Optimal tests for rare variant effects in sequencing association studies
- (2012) S. Lee et al. BIOSTATISTICS
- Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
- (2012) A. Albrechtsen et al. DIABETOLOGIA
- Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
- (2012) Angela Oppelt et al. EMBO REPORTS
- Multiway Admixture Deconvolution Using Phased or Unphased Ancestral Panels
- (2012) Claire Churchhouse et al. GENETIC EPIDEMIOLOGY
- GENCODE: The reference human genome annotation for The ENCODE Project
- (2012) J. Harrow et al. GENOME RESEARCH
- Defective PAX4 R192H transcriptional repressor activities associated with maturity onset diabetes of the young and early onset-age of type 2 diabetes
- (2012) Suwattanee Kooptiwut et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Bayesian refinement of association signals for 14 loci in 3 common diseases
- (2012) Julian B Maller et al. NATURE GENETICS
- Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
- (2012) Amélie Bonnefond et al. NATURE GENETICS
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
- (2012) Jeroen R Huyghe et al. NATURE GENETICS
- Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
- (2012) Jian Yang et al. NATURE GENETICS
- Detecting overlapping protein complexes in protein-protein interaction networks
- (2012) Tamás Nepusz et al. NATURE METHODS
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
- (2011) DIABETOLOGIA
- Transethnic meta-analysis of genomewide association studies
- (2011) Andrew P. Morris GENETIC EPIDEMIOLOGY
- Low-coverage sequencing: Implications for design of complex trait association studies
- (2011) Y. Li et al. GENOME RESEARCH
- Discovery and genotyping of genome structural polymorphism by sequencing on a population scale
- (2011) Robert E Handsaker et al. NATURE GENETICS
- Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
- (2011) Jaspal S Kooner et al. NATURE GENETICS
- A framework for variation discovery and genotyping using next-generation DNA sequencing data
- (2011) Mark A DePristo et al. NATURE GENETICS
- Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
- (2011) Yoon Shin Cho et al. NATURE GENETICS
- New approaches to disease mapping in admixed populations
- (2011) Michael F. Seldin et al. NATURE REVIEWS GENETICS
- The Importance of Synthetic Associations Will Only Be Resolved Empirically
- (2011) David B. Goldstein PLOS BIOLOGY
- Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results
- (2011) Naomi R. Wray et al. PLOS BIOLOGY
- Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
- (2011) Carl A. Anderson et al. PLOS BIOLOGY
- Transferability of Type 2 Diabetes Implicated Loci in Multi-Ethnic Cohorts from Southeast Asia
- (2011) Xueling Sim et al. PLoS Genetics
- GCTA: A Tool for Genome-wide Complex Trait Analysis
- (2010) Jian Yang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- dmGWAS: dense module searching for genome-wide association studies in protein–protein interaction networks
- (2010) Peilin Jia et al. BIOINFORMATICS
- METAL: fast and efficient meta-analysis of genomewide association scans
- (2010) C. J. Willer et al. BIOINFORMATICS
- Genetic Heterogeneity in Human Disease
- (2010) Jon McClellan et al. CELL
- Comparative Epigenomic Analysis of Murine and Human Adipogenesis
- (2010) Tarjei S. Mikkelsen et al. CELL
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
- (2010) A. McKenna et al. GENOME RESEARCH
- Discovery and characterization of chromatin states for systematic annotation of the human genome
- (2010) Jason Ernst et al. NATURE BIOTECHNOLOGY
- A map of open chromatin in human pancreatic islets
- (2010) Kyle J Gaulton et al. NATURE GENETICS
- Common SNPs explain a large proportion of the heritability for human height
- (2010) Jian Yang et al. NATURE GENETICS
- Variance component model to account for sample structure in genome-wide association studies
- (2010) Hyun Min Kang et al. NATURE GENETICS
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- (2010) Benjamin F Voight et al. NATURE GENETICS
- Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies
- (2010) A. Eyre-Walker PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rare Variants Create Synthetic Genome-Wide Associations
- (2010) Samuel P. Dickson et al. PLOS BIOLOGY
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- Finding the missing heritability of complex diseases
- (2009) Teri A. Manolio et al. NATURE
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations
- (2009) Alkes L. Price et al. PLoS Genetics
- Long-Range LD Can Confound Genome Scans in Admixed Populations
- (2008) Alkes L. Price et al. AMERICAN JOURNAL OF HUMAN GENETICS
- ForSim: a tool for exploring the genetic architecture of complex traits with controlled truth
- (2008) Brian W. Lambert et al. BIOINFORMATICS
- Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs
- (2008) Joshua M Korn et al. NATURE GENETICS
- Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes
- (2008) Valeriya Lyssenko et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clinical implications of a molecular genetic classification of monogenic β-cell diabetes
- (2008) Rinki Murphy et al. Nature clinical practice. Endocrinology & metabolism
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started