Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

Maternal Diabetes Causes Alterations of DNA Methylation Statuses of Some Imprinted Genes in Murine Oocytes1

(2013) Zhao-Jia Ge et al.   BIOLOGY OF REPRODUCTION

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

(2013) Antigone S. Dimas et al.   DIABETES

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

(2013) A. C. Nica et al.   GENOME RESEARCH

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model

(2013) Liguo Wang et al.   NUCLEIC ACIDS RESEARCH

Characterization and comparison of human nuclear and cytosolic editomes

(2013) L. Chen   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8

(2012) A. B. Hardy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies

(2012) Alessandra Fierabracci et al.   AUTOIMMUNITY REVIEWS

Matrix eQTL: ultra fast eQTL analysis via large matrix operations

(2012) A. A. Shabalin   BIOINFORMATICS

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes

(2012) Taman Mahdi et al.   Cell Metabolism

A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

(2012) Jalal Taneera et al.   Cell Metabolism

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

Detecting differential usage of exons from RNA-seq data

(2012) S. Anders et al.   GENOME RESEARCH

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

(2012) Sofia A. Andersson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pax6 Is Crucial for β-Cell Function, Insulin Biosynthesis, and Glucose-Induced Insulin Secretion

(2012) Yvan Gosmain et al.   MOLECULAR ENDOCRINOLOGY

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Diabetes in numbers

(2012) Tony Scully   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

(2012) Robert A Scott et al.   NATURE GENETICS

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

IEG's Role in Evaluating Climate Financing--Response

(2012) S. D. Donner et al.   SCIENCE

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Identification of novel transcripts in annotated genomes using RNA-Seq

(2011) A. Roberts et al.   BIOINFORMATICS

Transcriptomes of the major human pancreatic cell types

(2011) C. Dorrell et al.   DIABETOLOGIA

Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway

(2011) Yuedan Zhou et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

(2011) Jaspal S Kooner et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

(2011) Yoon Shin Cho et al.   NATURE GENETICS

A linear complexity phasing method for thousands of genomes

(2011) Olivier Delaneau et al.   NATURE METHODS

Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cells

(2011) Shin-ichi Harashima et al.   Journal of Diabetes Investigation

A framework for oligonucleotide microarray preprocessing

(2010) Benilton S. Carvalho et al.   BIOINFORMATICS

Global Epigenomic Analysis of Primary Human Pancreatic Islets Provides Insights into Type 2 Diabetes Susceptibility Loci

(2010) Michael L. Stitzel et al.   Cell Metabolism

The Transcription Factor Rfx3 Regulates  -Cell Differentiation, Function, and Glucokinase Expression

(2010) A. Ait-Lounis et al.   DIABETES

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

(2010) N. Soranzo et al.   DIABETES

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

The Imprinted GenePEG3Inhibits Wnt Signaling and Regulates Glioma Growth

(2010) Xiuli Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression

(2010) Michael S. Cunnington et al.   PLoS Genetics

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Detailed transcriptome atlas of the pancreatic beta cell

(2009) Burak Kutlu et al.   BMC Medical Genomics

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Transcription factor expression in the developing human fetal endocrine pancreas

(2008) B. M. Lyttle et al.   DIABETOLOGIA

RNA-seq: An assessment of technical reproducibility and comparison with gene expression arrays

(2008) J. C. Marioni et al.   GENOME RESEARCH

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE