Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

(2020) Jessica Segalés et al.   Nature Communications

Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis

(2019) Seri Choi et al.   Autophagy

Fibroblast growth factor 21 controls mitophagy and muscle mass

(2019) Lynette J. Oost et al.   Journal of Cachexia Sarcopenia and Muscle

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

(2019) Jordan J. S. VerPlank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

(2019) Fabrizio Pin et al.   FASEB JOURNAL

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

(2019) Francesca Ascenzi et al.   AGING CELL

Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure

(2019) Volker Adams et al.   Journal of Cachexia Sarcopenia and Muscle

Insulin/IGF1 signalling mediates the effects of β 2 ‐adrenergic agonist on muscle proteostasis and growth

(2019) Dawit A. Gonçalves et al.   Journal of Cachexia Sarcopenia and Muscle

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

(2019) M. Di Rienzo et al.   Science Advances

ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle

(2019) Jordan D. Fuqua et al.   FASEB JOURNAL

Methyltransferase-like 21c methylates and stabilizes the heat shock protein HSPA8 in type I myofibers in mice

(2019) Chao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space

(2019) Samuel M. Cadena et al.   Scientific Reports

A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice

(2019) Liam C. Hunt et al.   Cell Reports

An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse

(2019) Massiré Traoré et al.   Science Translational Medicine

Skeletal muscle mTORC1 regulates neuromuscular junction stability

(2019) Martina Baraldo et al.   Journal of Cachexia Sarcopenia and Muscle

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy

(2018) Bojana Kravic et al.   Autophagy

Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia

(2018) Parash Parajuli et al.   DEVELOPMENTAL CELL

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

(2018) Derek T Hall et al.   EMBO Molecular Medicine

Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease

(2018) Dwight D. Koeberl et al.   MOLECULAR THERAPY

Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis

(2018) Luca Madaro et al.   NATURE CELL BIOLOGY

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle

(2018) Gang Wang et al.   NATURE MEDICINE

Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy

(2018) Jie Yin et al.   Nature Communications

Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown

(2018) Janica Lea Wiederstein et al.   Cell Reports

PERK regulates skeletal muscle mass and contractile function in adult mice

(2018) Yann S. Gallot et al.   FASEB JOURNAL

ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation

(2018) Donghoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LY2495655, an antimyostatin antibody, in pancreatic cancer: a randomized, phase 2 trial

(2018) Talia Golan et al.   Journal of Cachexia Sarcopenia and Muscle

Long-noncoding RNA Atrolnc-1 promotes muscle wasting in mice with chronic kidney disease

(2018) Lijing Sun et al.   Journal of Cachexia Sarcopenia and Muscle

FoxO Transcription Factors are Critical Regulators of Diabetes-Related Muscle Atrophy

(2018) Brian T. O’Neill et al.   DIABETES

The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy

(2018) Jae-Sung You et al.   FASEB JOURNAL

Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis

(2018) Qing Zhang et al.   Journal of Cachexia Sarcopenia and Muscle

Muscle-specific Perilipin2 down-regulation affects lipid metabolism and induces myofiber hypertrophy

(2018) Maria Conte et al.   Journal of Cachexia Sarcopenia and Muscle

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

(2017) Bérengère Benoit et al.   NATURE MEDICINE

Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

(2017) Guohua Zhang et al.   Nature Communications

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

(2017) Marco Segatto et al.   Nature Communications

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

FoxO-dependent atrogenes vary among catabolic conditions and play a key role in muscle atrophy induced by hindlimb suspension

(2016) Lorenza Brocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women

(2016) Ulf Ekelund et al.   LANCET

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

(2016) Catherine E. Winbanks et al.   Science Translational Medicine

Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways

(2016) Xingcai Cai et al.   Scientific Reports

ATP Citrate Lyase Improves Mitochondrial Function in Skeletal Muscle

(2015) Suman Das et al.   Cell Metabolism

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

(2015) Adam L. Bujak et al.   Cell Metabolism

Muscle as a “Mediator” of Systemic Metabolism

(2015) Kedryn K. Baskin et al.   Cell Metabolism

Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials

(2015) José M Garcia et al.   LANCET ONCOLOGY

Muscle wasting in disease: molecular mechanisms and promising therapies

(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

The Mitochondrial Calcium Uniporter Controls Skeletal Muscle Trophism In Vivo

(2015) Cristina Mammucari et al.   Cell Reports

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

(2014) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

(2014) A. W. Beharry et al.   JOURNAL OF CELL SCIENCE

Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs

(2014) Christopher John Bowman et al.   NATURE CELL BIOLOGY

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

(2014) J. P. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age

(2013) Darren T. Hwee et al.   AGING CELL

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

(2013) Ivan Nemazanyy et al.   EMBO Molecular Medicine

Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

(2013) Marco Sandri   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

(2013) Catherine E. Winbanks et al.   JOURNAL OF CELL BIOLOGY

NF-κB–mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia

(2013) Wei A. He et al.   JOURNAL OF CLINICAL INVESTIGATION

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

(2012) Jorge L. Ruas et al.   CELL

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins

(2012) Rosanna Piccirillo et al.   EMBO JOURNAL

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

(2012) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

(2012) Catherine E. Winbanks et al.   JOURNAL OF CELL BIOLOGY

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

(2012) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

(2012) P. K. Paul et al.   MOLECULAR AND CELLULAR BIOLOGY

Posttranslational modifications control FoxO3 activity during denervation

(2011) Enrico Bertaggia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles

(2011) Paolo Grumati et al.   Autophagy

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

(2011) Noriaki Shimizu et al.   Cell Metabolism

Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

(2011) Leslie M. Baehr et al.   JOURNAL OF PHYSIOLOGY-LONDON

Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

(2010) Jeffrey J. Brault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy

(2010) Anna Raffaello et al.   JOURNAL OF CELL BIOLOGY

The TWEAK–Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice

(2010) Ashwani Mittal et al.   JOURNAL OF CELL BIOLOGY

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

(2010) Pradyut K. Paul et al.   JOURNAL OF CELL BIOLOGY

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation

(2009) Bert Blaauw et al.   FASEB JOURNAL

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

(2008) Kathryn R. Wagner et al.   ANNALS OF NEUROLOGY

Reduced Disability and Mortality Among Aging Runners

(2008) Eliza F. Chakravarty   ARCHIVES OF INTERNAL MEDICINE

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS