Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1

(2016) Bianca Maria Scicchitano et al.   Aging-US

Mechanisms regulating skeletal muscle growth and atrophy

(2013) Stefano Schiaffino et al.   FEBS Journal

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Myostatin is associated with age-related human muscle stem cell dysfunction

(2012) Bryon R. McKay et al.   FASEB JOURNAL

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

(2012) Catherine E. Winbanks et al.   JOURNAL OF CELL BIOLOGY

The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms

(2012) Lorenza Brocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Role of satellite cells in muscle growth and maintenance of muscle mass

(2012) G. Pallafacchina et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice

(2011) A. J. Courey et al.   BLOOD

PKB signaling and atrogene expression in skeletal muscle of aged mice

(2011) Megan Gaugler et al.   JOURNAL OF APPLIED PHYSIOLOGY

Retraction: Myostatin Induces Degradation of Sarcomeric Proteins through a Smad3 Signaling Mechanism During Skeletal Muscle Wasting

(2011) Sudarsanareddy Lokireddy et al.   MOLECULAR ENDOCRINOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

A pathway that links reproductive status to lifespan in Caenorhabditis elegans

(2010) Cynthia Kenyon   Annals of the New York Academy of Sciences

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Mitochondrial fission and remodelling contributes to muscle atrophy

(2010) Vanina Romanello et al.   EMBO JOURNAL

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

(2010) Subhash D. Katewa et al.   EXPERIMENTAL GERONTOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation

(2009) Bert Blaauw et al.   FASEB JOURNAL

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

(2008) Yasuhiro Izumiya et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle

(2008) Bert Blaauw et al.   HUMAN MOLECULAR GENETICS

Identification of a Novel Pool of Extracellular Pro-myostatin in Skeletal Muscle

(2008) Sarah B. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL