Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

TRIM50 regulates Beclin 1 proautophagic activity

(2018) Carmela Fusco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Negative regulation of MAVS-mediated antiviral signaling by the mitochondrial protein LRPPRC during HCV infection

(2018) Giulia Refolo et al.   HEPATOLOGY

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

(2018) Anthea Di Rita et al.   Nature Communications

NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway

(2017) Run Fang et al.   JOURNAL OF IMMUNOLOGY

Emerging Mechanisms in Initiating and Terminating Autophagy

(2017) Manuela Antonioli et al.   TRENDS IN BIOCHEMICAL SCIENCES

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

(2017) Qing Yang et al.   PLoS Pathogens

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

(2016) Marios G Koliopoulos et al.   EMBO JOURNAL

TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours

(2016) Elisa Lazzari et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

(2016) Francesca Nazio et al.   JOURNAL OF CELL BIOLOGY

Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

(2016) Tomonori Kimura et al.   JOURNAL OF CELL SCIENCE

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response

(2016) Preeti Bharaj et al.   PLoS Pathogens

Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice

(2015) Martina Chrisam et al.   Autophagy

Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

(2015) Anna Ulbricht et al.   Autophagy

The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2

(2015) Ekaterina I. Mokhonova et al.   HUMAN MOLECULAR GENETICS

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Erratum: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

(2015) Valentina Cianfanelli et al.   NATURE CELL BIOLOGY

Muscle wasting in disease: molecular mechanisms and promising therapies

(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy is required and protects against apoptosis during myoblast differentiation

(2014) Elliott M. McMillan et al.   BIOCHEMICAL JOURNAL

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance

(2014) Rodrigo Troncoso et al.   CELL CYCLE

RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy

(2014) Pengyan Xia et al.   CELL RESEARCH

InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins

(2014) Gijs A. Versteeg et al.   CYTOKINE & GROWTH FACTOR REVIEWS

AMBRA1 Interplay with Cullin E3 Ubiquitin Ligases Regulates Autophagy Dynamics

(2014) Manuela Antonioli et al.   DEVELOPMENTAL CELL

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response

(2014) Ricardo Rajsbaum et al.   IMMUNITY

TRAF6 Inhibition Rescues Dexamethasone-Induced Muscle Atrophy

(2014) Hualin Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

(2014) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Zebrafish ambra1a and ambra1b Knockdown Impairs Skeletal Muscle Development

(2014) Tatjana Skobo et al.   PLoS One

Erratum: Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2014) C De Palma et al.   Cell Death & Disease

Signaling pathways controlling skeletal muscle mass

(2013) Marc A. Egerman et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies

(2013) M. Sandri et al.   JOURNAL OF CELL SCIENCE

Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease

(2013) Anna Vainshtein et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

A patient with limb girdle muscular dystrophy carries a TRIM32 deletion, detected by a novel CGH array, in compound heterozygosis with a nonsense mutation

(2013) M. Neri et al.   NEUROMUSCULAR DISORDERS

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Skeletal muscle autophagy: a new metabolic regulator

(2013) Brian A. Neel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

(2012) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H

(2012) Elena Kudryashova et al.   JOURNAL OF CLINICAL INVESTIGATION

TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and Is Necessary for Normal Adult Muscle Regeneration

(2012) Sarah Nicklas et al.   PLoS One

Seeing is believing: The impact of electron microscopy on autophagy research

(2011) Eeva-Liisa Eskelinen et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype

(2011) E. Kudryashova et al.   HUMAN MOLECULAR GENETICS

Autophagy is increased in laminin α2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A

(2011) Virginie Carmignac et al.   HUMAN MOLECULAR GENETICS

Parkin Interacts with Ambra1 to Induce Mitophagy

(2011) C. Van Humbeeck et al.   JOURNAL OF NEUROSCIENCE

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

(2010) Pradyut K. Paul et al.   JOURNAL OF CELL BIOLOGY

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

(2009) Elena Kudryashova et al.   HUMAN MOLECULAR GENETICS

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H

(2007) Valentina Saccone et al.   HUMAN MUTATION