The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy
出版年份 2020 全文链接
标题
The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy
作者
关键词
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出版物
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2020-12-02
DOI
10.1002/med.21761
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- SOCS3 Deletion in T Lymphocytes Suppresses Development of Chronic Ocular Inflammation via Upregulation of CTLA-4 and Expansion of Regulatory T Cells
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- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- Ellagic Acid and Embelin Affect Key Cellular Components of Pancreatic Adenocarcinoma, Cancer, and Stellate Cells
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- Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition
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- MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines
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- Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells
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- A Potent Anti-Carcinoma and Anti-Acute Myeloblastic Leukemia Agent, AG490
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- Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer
- (2012) Remya Prasannan et al. BIOCHEMICAL PHARMACOLOGY
- S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma
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- Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells
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- S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites
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- Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
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- STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation
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- Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol
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- Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling
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- Let-7 Expression Is a Significant Determinant of Response to Chemotherapy through the Regulation of IL-6/STAT3 Pathway in Esophageal Squamous Cell Carcinoma
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- The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain
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- Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans
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- Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
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- Activation of IL-6R/JAK1/STAT3 Signaling Induces De Novo Resistance to Irreversible EGFR Inhibitors in Non-Small Cell Lung Cancer with T790M Resistance Mutation
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- Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3
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- Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN
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- HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis
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- STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17
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- STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells
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- Hallmarks of Cancer: The Next Generation
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- Direct reprogramming of stem cell properties in colon cancer cells by CD44
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- Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer
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- Roles of STAT3 and ZEB1 Proteins in E-cadherin Down-regulation and Human Colorectal Cancer Epithelial-Mesenchymal Transition
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- Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
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- From branch to bedside: Youyou Tu is awarded the 2011 Lasker~DeBakey Clinical Medical Research Award for discovering artemisinin as a treatment for malaria
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- The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
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- Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin Expression on M2-Polarized and Tumor-Associated Macrophages Is Macrophage-CSF Dependent and Enhanced by Tumor-Derived IL-6 and IL-10
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- IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway
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- Molecular mechanisms and clinical applications of angiogenesis
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- Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer
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- Lestaurtinib Inhibition of the JAK/STAT Signaling Pathway in Hodgkin Lymphoma Inhibits Proliferation and Induces Apoptosis
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- STAT3 Knockdown Reduces Pancreatic Cancer Cell Invasiveness and Matrix Metalloproteinase-7 Expression in Nude Mice
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- STAT3 controls myeloid progenitor growth during emergency granulopoiesis
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- Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
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- TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients
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- γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
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- Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages
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- MicroRNA-20a Overexpression Inhibited Proliferation and Metastasis of Pancreatic Carcinoma Cells
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- Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor
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- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
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- STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
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- Natural products for cancer chemotherapy
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- AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
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- Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment
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- An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation
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- Acetylation and activation of STAT3 mediated by nuclear translocation of CD44
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- Stat3 promotes directional cell migration by regulating Rac1 activity via its activator PIX
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- Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells
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- A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells
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- SOCS1, SOCS3, and PIAS1 Promote Myogenic Differentiation by Inhibiting the Leukemia Inhibitory Factor-Induced JAK1/STAT1/STAT3 Pathway
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- Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo
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- Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells
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- Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation
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- Function of Mitochondrial Stat3 in Cellular Respiration
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- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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- STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells
- (2009) Maureen M. Sherry et al. STEM CELLS
- Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells
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- The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia
- (2008) Stefan Kasper et al. LEUKEMIA RESEARCH
- LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells
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- SOCS regulation of the JAK/STAT signalling pathway
- (2008) Ben A. Croker et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- STAT3: A critical transcription activator in angiogenesis
- (2007) Zhong Chen et al. MEDICINAL RESEARCH REVIEWS
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