γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent

Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors

(2010) Fengjuan Li et al.   ATHEROSCLEROSIS

Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases

(2010) Bharat B. Aggarwal et al.   BIOCHEMICAL PHARMACOLOGY

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells

(2010) Angeline Wei Ling Chua et al.   BIOCHEMICAL PHARMACOLOGY

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells

(2010) Feng Li et al.   CANCER LETTERS

 -Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment

(2010) A. B. Kunnumakkara et al.   CANCER RESEARCH

γ- and δ-tocotrienols exert a more potent anticancer effect than α-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression

(2010) Elisa Pierpaoli et al.   LIFE SCIENCES

In vivo Evidence of γ-Tocotrienol as a Chemosensitizer in the Treatment of Hormone-Refractory Prostate Cancer

(2010) W.N. Yap et al.   PHARMACOLOGY

γ-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line

(2010) Sheng Bi et al.   TOXICOLOGY

Inflammation and Liver Cancer

(2009) C. Berasain et al.   Annals of the New York Academy of Sciences

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

Novel treatments for hepatocellular cancer

(2009) S.H. Kerr et al.   CANCER LETTERS

Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells

(2009) Wei Ney Yap et al.   CANCER LETTERS

Anti-proliferative effects of γ-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression

(2009) G. V. Samant et al.   CELL PROLIFERATION

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

STAT3 as a Central Regulator of Tumor Metastases

(2009) Eswaran Devarajan et al.   CURRENT MOLECULAR MEDICINE

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Combination chemotherapy of doxorubicin and paclitaxel for hepatocellular carcinoma in vitro and in vivo

(2009) Cheng Jin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Inhibitory effects of γ-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells☆☆☆

(2009) Hui-Kun Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells

(2009) Korehito Kashiwagi et al.   LIFE SCIENCES

Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors

(2009) Fang Fang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of proliferation and induction of apoptosis by γ-tocotrienol in human colon carcinoma HT-29 cells

(2009) Wei-Li Xu et al.   NUTRITION

Suppression of Tumor Growth by Palm Tocotrienols Via the Attenuation of Angiogenesis

(2009) Wong Weng-Yew et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Evidence ofγ-Tocotrienol as an Apoptosis-Inducing, Invasion-Suppressing, and Chemotherapy Drug-Sensitizing Agent in Human Melanoma Cells

(2009) Piek Ngoh Chang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling

(2009) L Lin et al.   ONCOGENE

Current management strategy of hepatocellular carcinoma

(2009) Bernardino Rampone et al.   WORLD JOURNAL OF GASTROENTEROLOGY

γ-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways

(2008) W N Yap et al.   BRITISH JOURNAL OF CANCER

Synergistic Growth Inhibition by 9-cis-Retinoic Acid Plus Trastuzumab in Human Hepatocellular Carcinoma Cells

(2008) H. Tatebe et al.   CLINICAL CANCER RESEARCH

STAT 3 as a Target for Cancer Drug Discovery

(2008) Luca Costantino et al.   CURRENT MEDICINAL CHEMISTRY

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY

Specific accumulation of γ- and δ-tocotrienols in tumor and their antitumor effect in vivo

(2008) Yuhei Hiura et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

γ-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells

(2008) Wenguang Sun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Interleukin-6 Mediates G0/G1 Growth Arrest in Hepatocellular Carcinoma Through a STAT 3-Dependent Pathway

(2007) Dairmuid M. Moran et al.   JOURNAL OF SURGICAL RESEARCH