标题
FLT3 inhibitors in acute myeloid leukemia
作者
关键词
FMS-like tyrosine kinase 3 inhibitors, Acute myeloid leukemia, Midostaurin, FLT3
出版物
Journal of Hematology & Oncology
Volume 11, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-12-04
DOI
10.1186/s13045-018-0675-4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- RNA-basedFLT3-ITD allelic ratio is associated with outcome and ex vivo response to FLT3 inhibitors in pediatric AML
- (2018) David G. J. Cucchi et al. BLOOD
- Effect of sorafenib on the outcomes of patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation
- (2018) Li Xuan et al. CANCER
- Combined inhibition of PI3Kδ and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia
- (2018) Ye He et al. CANCER LETTERS
- Sorafenib Dose Recommendation in Acute Myeloid Leukemia Based on Exposure-FLT3 Relationship
- (2018) Tao Liu et al. CTS-Clinical and Translational Science
- Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines
- (2018) Neetu Dayal et al. Future Medicinal Chemistry
- CAR T-cells targeting FLT3 have potent activity against FLT3−ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib
- (2018) Hardikkumar Jetani et al. LEUKEMIA
- Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
- (2018) Nimitha R Mathew et al. NATURE MEDICINE
- Chimeric Antigen Receptor Therapy
- (2018) Carl H. June et al. NEW ENGLAND JOURNAL OF MEDICINE
- The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow
- (2018) Andrzej Lange et al. PLoS One
- CAR T cell immunotherapy for human cancer
- (2018) Carl H. June et al. SCIENCE
- Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death
- (2018) Amanda Tomie Ouchida et al. Cell Death & Disease
- Clinical Profile of Gilteritinib in Japanese Patients with Relapsed/Refractory AML: an Open-Label Phase 1 Study
- (2018) Kensuke Usuki et al. CANCER SCIENCE
- Long-term survival of sorafenib-treated FLT3-ITD–positive acute myeloid leukaemia patients relapsing after allogeneic stem cell transplantation
- (2017) S.K. Metzelder et al. EUROPEAN JOURNAL OF CANCER
- Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia
- (2017) Masamichi Mori et al. INVESTIGATIONAL NEW DRUGS
- The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia
- (2017) Ya-Zhen Qin et al. Journal of Hematology & Oncology
- Clinical trials of CAR-T cells in China
- (2017) Bingshan Liu et al. Journal of Hematology & Oncology
- Emerging therapies for acute myeloid leukemia
- (2017) Caner Saygin et al. Journal of Hematology & Oncology
- Recent developments in immunotherapy of acute myeloid leukemia
- (2017) Felix S. Lichtenegger et al. Journal of Hematology & Oncology
- The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model
- (2017) Yueh-Chwen Hsu et al. Journal of Hematology & Oncology
- Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy
- (2017) Bingshan Liu et al. Journal of Hematology & Oncology
- Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia
- (2017) Hubert Hackl et al. Journal of Hematology & Oncology
- Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia
- (2017) Yan Li et al. Journal of Hematology & Oncology
- Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
- (2017) Mingxue Fan et al. Journal of Hematology & Oncology
- Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 study
- (2017) Alexander E Perl et al. LANCET ONCOLOGY
- Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
- (2017) Richard M. Stone et al. NEW ENGLAND JOURNAL OF MEDICINE
- Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia
- (2017) Hagop Kantarjian et al. NEW ENGLAND JOURNAL OF MEDICINE
- A randomized assessment of adding the kinase inhibitor lestaurtinib to first-line chemotherapy for FLT3-mutated AML
- (2016) Steven Knapper et al. BLOOD
- Successful molecular targeted treatment of AML in pregnancy with Azacitidine and Sorafenib with no adverse fetal outcomes
- (2016) Ali J. Mahdi et al. BRITISH JOURNAL OF HAEMATOLOGY
- Haematopoietic cell transplantation with and without sorafenib maintenance for patients withFLT3-ITD acute myeloid leukaemia in first complete remission
- (2016) Andrew M. Brunner et al. BRITISH JOURNAL OF HAEMATOLOGY
- Cabozantinib is selectively cytotoxic in acute myeloid leukemia cells with FLT3-internal tandem duplication (FLT3-ITD)
- (2016) Jeng-Wei Lu et al. CANCER LETTERS
- A Phase I Study of Quizartinib Combined with Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study
- (2016) Todd M. Cooper et al. CLINICAL CANCER RESEARCH
- The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma
- (2016) M. Ruella et al. CLINICAL CANCER RESEARCH
- Midostaurin, bortezomib and MEC in relapsed/refractory acute myeloid leukemia
- (2016) Alison R. Walker et al. LEUKEMIA & LYMPHOMA
- Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor
- (2016) John M. Hatcher et al. ACS Medicinal Chemistry Letters
- Synergistic effect of sorafenib and cGvHD in patients with high-risk FLT3-ITD+AML allows long-term disease control after allogeneic transplantation
- (2015) A. Tschan-Plessl et al. ANNALS OF HEMATOLOGY
- A phase I/II study of sunitinib and intensive chemotherapy in patients over 60 years of age with acute myeloid leukaemia and activatingFLT3mutations
- (2015) Walter Fiedler et al. BRITISH JOURNAL OF HAEMATOLOGY
- Decitabine and Sorafenib Therapy in FLT-3 ITD-Mutant Acute Myeloid Leukemia
- (2015) Monica R. Muppidi et al. Clinical Lymphoma Myeloma & Leukemia
- Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): a multicentre, phase 2, randomised controlled trial
- (2015) Christoph Röllig et al. LANCET ONCOLOGY
- Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study
- (2015) Max S Topp et al. LANCET ONCOLOGY
- Phase I dose escalation study of lestaurtinib in patients with myelofibrosis
- (2015) Elizabeth O. Hexner et al. LEUKEMIA & LYMPHOMA
- TTT-3002 is a novel FLT3 tyrosine kinase inhibitor with activity against FLT3-associated leukemias in vitro and in vivo
- (2014) H. Ma et al. BLOOD
- G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia
- (2014) H. K. Lee et al. BLOOD
- Treatment with FLT3 inhibitor in patients withFLT3-mutated acute myeloid leukemia is associated with development of secondaryFLT3-tyrosine kinase domain mutations
- (2014) Yesid Alvarado et al. CANCER
- FLT3 Kinase Inhibitor TTT-3002 Overcomes Both Activating and Drug Resistance Mutations in FLT3 in Acute Myeloid Leukemia
- (2014) H. S. Ma et al. CANCER RESEARCH
- Phase I study of cladribine, cytarabine, granulocyte colony stimulating factor (CLAG regimen) and midostaurin and all-trans retinoic acid in relapsed/refractory AML
- (2014) Giridharan Ramsingh et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3
- (2014) Zhihong Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Preclinical Evaluation of AMG 925, a FLT3/CDK4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
- (2014) K. Keegan et al. MOLECULAR CANCER THERAPEUTICS
- Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia
- (2013) E. I. Zimmerman et al. BLOOD
- Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation
- (2013) F. Ravandi et al. BLOOD
- Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD-Positive Acute Myeloid Leukemia
- (2013) S. D. Baker et al. CLINICAL CANCER RESEARCH
- Phase I Study of Quizartinib Administered Daily to Patients With Relapsed or Refractory Acute Myeloid Leukemia Irrespective of FMS-Like Tyrosine Kinase 3–Internal Tandem Duplication Status
- (2013) Jorge E. Cortes et al. JOURNAL OF CLINICAL ONCOLOGY
- Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms
- (2013) Kerstin Maria Kampa-Schittenhelm et al. Molecular Cancer
- Effector mechanisms of sunitinib-induced G1 cell cycle arrest, differentiation, and apoptosis in human acute myeloid leukaemia HL60 and KG-1 cells
- (2012) Chieh-Lin Jerry Teng et al. ANNALS OF HEMATOLOGY
- Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia
- (2012) R M Stone et al. LEUKEMIA
- Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
- (2011) M. Levis et al. BLOOD
- The FLT3 inhibitor tandutinib (formerly MLN518) has sequence-independent synergistic effects with cytarabine and daunorubicin
- (2011) Marcus M. Schittenhelm et al. CELL CYCLE
- Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation
- (2010) Wei Zhao et al. ANTI-CANCER DRUGS
- How I treat acute myeloid leukemia
- (2010) J. M. Rowe et al. BLOOD
- AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
- (2009) P. P. Zarrinkar et al. BLOOD
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