期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 43, 期 5, 页码 1517-1522出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2013.2087
关键词
hematein; casein kinase II; Wnt; lung cancer; xenograft
类别
资金
- NIH [5 R01 CA140654-03]
- Oberman Foundation, Inc.
- Jeffrey and Karen Peterson Family Foundation
- Barbara Isackson Lung Cancer Research Fund
Casein kinase II (CK2) inhibitors suppress cancer cell growth. In this study, we examined the inhibitory effects of a novel CK2 inhibitor, hematein, on tumor growth in a murine xenograft model. We found that in lung cancer cells, hematein inhibited cancer cell growth, Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increased apoptosis. In a murine xenograft model of lung cancer, hematein inhibited tumor growth without significant toxicity to the mice tested. Molecular docking showed that hematein binds to CK2 alpha in durable binding sites. Collectively, our results suggest that hematein is an allosteric inhibitor of protein kinase CK2 and has antitumor activity to lung cancer.
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