Article
Pharmacology & Pharmacy
Nongyao Nonpanya, Kittipong Sanookpan, Nicharat Sriratanasak, Chanida Vinayanuwattikun, Duangdao Wichadakul, Boonchoo Sritularak, Pithi Chanvorachote
Summary: Artocarpin targets FAK to suppress EMT and migratory behaviors of lung cancer cells, without affecting normal lung cells.
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Article
Anatomy & Morphology
Xiangjun Lu, Jian Shen, Siyuan Huang, Haitao Wang, Dongdong Liu
Summary: This study demonstrates that the low expression of CLEC3B in LUAD cells leads to decreased cell adhesion capability, enhanced EMT, migration, and invasion, which is associated with the p53 signaling pathway.
Article
Pharmacology & Pharmacy
Huaguo Liang, Zexin Chen, Ruihui Yang, Qingsong Huang, Hongmei Chen, Wanting Chen, Li Zou, Peng Wei, Shijie Wei, Yongxia Yang, Yongli Zhang
Summary: The polyphenolic compound Methyl gallate (MG) found in plants can inhibit the proliferation, migration, and invasion of HCC cells both in vitro and in vivo. The therapeutic mechanism of MG potentially involves the regulation of the AMPK/NF-kappa B pathway, which influences the epithelial-mesenchymal transition and MMP expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Weiyan Zou, Yi Zhang, Guangfu Bai, Jialu Zhuang, Lin Wei, Zishu Wang, Meiqun Sun, Junbin Wang
Summary: siRNA-induced CD44 knockdown inhibits the biological behaviors of colorectal cancer stem cells (CSCs), including proliferation, migration, invasion, and tumorigenesis. It also promotes apoptosis, induces cell-cycle arrest, increases sensitivity to chemotherapy, and inhibits metastasis by suppressing epithelial-mesenchymal transition (EMT).
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Qin Yu, Jianzhang Wang, Tiantian Li, Xinyue Guo, Shaojie Ding, Xuan Che, Libo Zhu, Yangying Peng, Xinxin Xu, Gen Zou, Xinmei Zhang
Summary: RON, a receptor tyrosine kinase, promotes endometriosis development by facilitating epithelial-mesenchymal transition (EMT) of endometrial epithelial cells. Inhibition or knockdown of RON expression suppresses the migration and invasion of endometrial epithelial cells. Targeting RON may offer a new therapeutic approach for endometriosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sophie E. Ketchen, Filomena O. Gamboa-Esteves, Sean E. Lawler, Michal O. Nowicki, Arndt Rohwedder, Sabine Knipp, Sally Prior, Susan C. Short, John E. Ladbury, Anke Bruening-Richardson
Summary: Cancer cell invasion, a crucial aspect of tumour metastasis, is being targeted for improved treatment through the development of migrastatics. The study investigates the role of CCN1 in GBM cell migration and reveals a potential drug resistance mechanism involving CCG-1423. Despite its reported function as a migration inhibitor, CCG-1423 was found to promote GBM cell migration via mesenchymal-amoeboid transition (MAT). Furthermore, CCN1 is identified as a potential biomarker for monitoring and predicting GBM recurrence, which could enhance treatment effectiveness and survival rates for this aggressive cancer.
Article
Otorhinolaryngology
Caifeng Zhou, Huiling Cao, Xinyu Meng, Qiyao Zhang
Summary: The study revealed that lnc-MEG3 inhibits malignant behaviors of NPC by regulating the expression of SQSTM1, suggesting its potential as a therapeutic target for the disease.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Multidisciplinary Sciences
Tianying Zheng, Wenfei Han, Aijun Wang, Yonggang Wang
Summary: This study reveals that miR-128-3p inhibits epithelial-mesenchymal transition, invasion, and migration of pancreatic cancer cells by targeting ZEB1.
Article
Oncology
Wei-Jiang Zhao, Yi-Pu Fan, Guan-Yong Ou, Xin-Yu Qiao
Summary: This study found that the expression of LASS2 decreased with the increase of glioma grade. Overexpression of LASS2 inhibited the proliferation and migration of glioma stem cells, and promoted tumor cell apoptosis and the differentiation of glioma cells.
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Young-Sun Lee, Osung Kwon, Geuk-Rae Jeong, Junyeol Noh, Sung Eun Kim, Gwan-Su Yi, Eun Mi Hwang, Jae-Yong Park
Summary: The expression of TTYH1 is associated with the migration and invasion of osteosarcoma cells. Silencing TTYH1 expression using siRNA significantly inhibits cell migration and invasion, as well as reduces the expression of epithelial-mesenchymal transition markers and matrix metalloproteinases.
Article
Pathology
Zhe Cheng, Suwen Li, Jiaqi Yuan, Yongdong Li, Shan Cheng, Shilu Huang, Jun Dong
Summary: In this study, the expression patterns of HDAC1 and its impact on prognosis in glioblastoma (GBM) patients were evaluated based on TCGA and CGGA databases. High expression of HDAC1 was found to be associated with poor prognosis in GBM, and its interaction with the EMT-related protein VIM was explored. Functional enrichment analysis further revealed the enrichment of cancer markers in GBM tissues with high HDAC1 expression. In vitro and in vivo experiments demonstrated that an HDAC1 inhibitor could inhibit the EMT process and affect the invasive ability of GBM cells.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Genetics & Heredity
Ameng Shi, Ting Wang, Miao Jia, Lei Dong, Haitao Shi
Summary: The study revealed that the SDF-1/CXCR7 axis is crucial in promoting migration, invasion, and EMT in gastric cancer cells, suggesting that targeting CXCR7 suppression could be a potential strategy for inhibiting gastric cancer metastasis.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Victor H. Villar, Maria Francesca Allega, Ruhi Deshmukh, Tobias Ackermann, Mark A. Nakasone, Johan Vande Voorde, Thomas M. Drake, Janina Oetjen, Algernon Bloom, Colin Nixon, Miryam Muller, Stephanie May, Ee Hong Tan, Lars Vereecke, Maude Jans, Gillian Blancke, Daniel J. Murphy, Danny T. Huang, David Y. Lewis, Thomas G. Bird, Owen J. Sansom, Karen Blyth, David Sumpton, Saverio Tardito
Summary: This study reveals that glutamine synthetase (GS) can produce a methylated glutamine analog, N-5-methylglutamine, during the synthesis of glutamine. GS inhibition leads to decreased levels of N-5-methylglutamine in the liver and circulation in mice. The levels of N-5-methylglutamine in urine correlate with tumor burden and GS expression in a liver cancer model.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuhao Sun, Shuai Yuan, Xuejie Chen, Jing Sun, Rahul Kalla, Lili Yu, Lijuan Wang, Xuan Zhou, Xiangxing Kong, Therese Hesketh, Gwo-tzer Ho, Kefeng Ding, Malcolm Dunlop, Susanna C. Larsson, Jack Satsangi, Jie Chen, Xiaoyan Wang, Xue Li, Evropi Theodoratou, Edward L. Giovannucci
Summary: This study investigated the associations between genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD). The results showed that high genetic risk and unhealthy lifestyle were associated with increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC). However, for individuals with high genetic risk, adhering to a healthy lifestyle can reduce the risk by nearly 50%.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Urology & Nephrology
Matthew Trail, Muhammad Sajid Waheed Rahman, William J. Broadhurst, James P. Blackmur, Abhishek Sharma, Etienne Chew, Marie O'Donnell, Julian Y. Keanie, John Brush, John Taylor, Simon Phipps, Ben Thomas, Edward A. A. Mains, S. Alan McNeill, Steve Leung, Mark L. Cutress, Alexander Laird
Summary: The aim of this study was to identify factors that may predict a diagnosis of upper urinary tract urothelial cell carcinoma (UTUC) and determine which patients can proceed directly to radical nephroureterectomy (RNU) without the delay of diagnostic ureteroscopy (URS). The study identified specific factors, such as visible haematuria, solid lesion on imaging, and a history of smoking, which may assist clinicians in selecting patients for RNU without the need for URS. These findings can be applied in a prospective multicentre analysis to further improve the selection process.
Letter
Oncology
Rachel H. Horton, Malcolm G. Dunlop, Richard S. Houlston, Anneke Lucassen, Margaret McCartney, Alan McNeill, Amit Sud
BRITISH JOURNAL OF CANCER
(2023)
Article
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Bien, Virginia Diez-Obrero, Li Li, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Harris, Victoria Svinti, Kevin McDonnell, Susan Farrington, James Studd, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Scacheri, James Studd, Jeroen Huyghe, Tabitha Harrison, David Shibata, Christopher Haiman, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Potter, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Shibata, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Boehm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Shibata, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Gruber, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Summary: This study identified 205 independent risk associations for colorectal cancer through a genome-wide association study meta-analysis. Transcriptome and methylome analysis further revealed 53 risk associations. These findings provide insights into the genetic and molecular mechanisms of colorectal oncogenesis and suggest potential targets for new treatment and prevention strategies.
Article
Biochemistry & Molecular Biology
Fuhui Chen, Sevim B. Gurler, David Novo, Cigdem Selli, Denis G. Alferez, Secil Eroglu, Kyriaki Pavlou, Jingwei Zhang, Andrew H. Sims, Neil E. Humphreys, Antony Adamson, Andrew Campbell, Owen J. Sansom, Cathy Tournier, Robert B. Clarke, Keith Brennan, Charles H. Streuli, Ahmet Ucar
Summary: Breast cancer stem cells (BCSC), responsible for treatment resistance, tumor recurrence, and metastasis, have been hindered by heterogeneity and lack of selective molecular targets. This study identifies RAC1B as a clinically relevant molecular target for BCSC-targeting therapies, highlighting its role in the maintenance of BCSC and their chemoresistance to doxorubicin.
Article
Oncology
Wanxin Li, Xuan Zhou, Shuai Yuan, Lijuan Wang, Lili Yu, Jing Sun, Jie Chen, Qian Xiao, Zhongxiao Wan, Ju-Sheng Zheng, Cai-Xia Zhang, Susanna C. Larsson, Susan M. Farrington, Philip Law, Richard S. Houlston, Ian Tomlinson, Ke-Feng Ding, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Summary: This study uses forward and reverse Mendelian randomization analysis to discover a causal relationship between genetic susceptibility and two microbiota taxa related to colorectal adenoma, highlighting the importance of further studies exploring the causal mechanisms linking host genetic variation with the gut microbiome and susceptibility to colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Biochemistry & Molecular Biology
Jing Sun, Lijuan Wang, Xuan Zhou, Lidan Hu, Shuai Yuan, Zilong Bian, Jie Chen, Yingshuang Zhu, Susan M. Farrington, Harry Campbell, Kefeng Ding, Dongfeng Zhang, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Summary: This study identified three novel genetic variants and three genes associated with colorectal cancer (CRC) through a systematic genome-wide analysis. These genetic variants significantly influenced the expression of their respective genes in colon tissue and interacted with environmental factors such as smoking and alcohol drinking. The findings provide important insights into the genetic architecture of CRC.
HUMAN MOLECULAR GENETICS
(2023)
Correction
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Diez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Broderick, James Studd, Jeroen Huyghe, Tabitha Harrison, David Conti, Christopher Dampier, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Hopper, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Duggan, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Bohm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Hunter, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Chanock, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Article
Genetics & Heredity
Lili Yu, Lijuan Wang, Jing Sun, Xuan Zhou, Yeting Hu, Lidan Hu, Yazhou He, Chunqing Lin, Jie Chen, Xiaolin Xu, Malcolm G. Dunlop, Evropi Theodoratou, Kefeng Ding, Xue Li
Summary: This study developed a risk score based on m6A-related gene expression signatures for predicting the overall survival of colorectal cancer (CRC) patients. The risk score was significantly associated with CRC survival and had predictive value in different age, sex, and tumor stage groups. Furthermore, high-risk patients showed distinct patterns of immune cell composition and tumor microenvironment compared to low-risk patients.
FRONTIERS IN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, T. O. P. P. I. C. Study Group, Ibd-biom Consortium, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi
Summary: This study aimed to investigate the DNA methylation alterations associated with Crohn's disease (CD) recurrence following surgery. The results showed differentially methylated positions and differentially variable positions in patients with CD recurrence. The study also validated the previously reported CD-associated methylome.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Natasha Malik, Jodie Hay, Hassan N. B. Almuhanna, Karen M. Dunn, Jamie Lees, Jennifer Cassels, Jiatian Li, Rinako Nakagawa, Owen J. Sansom, Alison M. Michie
Summary: This study reveals the essential role of mTORC1 in the initiation/maintenance of leukemia in a CLL model and identifies the inactivation of eEF2 activity as a novel therapeutic target for blocking CLL progression.
Letter
Surgery
Adam D. Gerrard, Malcolm G. Dunlop, Farhat V. N. Din
BRITISH JOURNAL OF SURGERY
(2023)
Article
Urology & Nephrology
James Peter Blackmur, Etienne Chew, Matthew Trail, Katie Brodie, Nicola Santoni, Flora Rodger, David Hamilton, Fortis Gaba, Sophie Randall, Sarika Nalagatla, Brian Little, Khalid Janjua, Clare Sweeney, Andrew Martindale, Khaver Qureshi, Antony Riddick, Kevin O'Connor, S. Alan McNeill, Simon Phipps, Mark L. Cutress, Edward A. A. Mains, Ian Dunn, Sarah Reid, Grant D. Stewart, Gavin Lamb, Muhammad Zeeshan Aslam, Steve Leung, Ross Clark, Ian Wilson, Grenville Oades, Alexander Chapman, Alexander Laird
Summary: This study compared different excision techniques in patients with upper urinary tract urothelial carcinoma (UTUC), and found that the excision technique does not affect bladder tumor recurrence. However, prior ureteroscopy, lower ureteric tumor location, previous bladder cancer, and male gender are associated with a higher recurrence rate.
WORLD JOURNAL OF UROLOGY
(2023)
Review
Oncology
Simon T. Barry, Dmitry I. Gabrilovich, Owen J. Sansom, Andrew D. Campbell, Jennifer P. Morton
Summary: Myeloid cells in the tumour microenvironment have a significant impact on tumour progression, making them a key target for clinical therapies. However, large-scale clinical trials targeting these cells have had limited success. Understanding the specific functions and roles of different myeloid cell subpopulations within the tumour microenvironment could improve the design of successful clinical trials for myeloid-targeting therapies.
NATURE REVIEWS CANCER
(2023)