Article
Endocrinology & Metabolism
Sung-Jin Bae, Yunju Jo, Min Kyoung Cho, Jung-Sook Jin, Jin-Young Kim, Jaewon Shim, Yun Hak Kim, Jang-Kyung Park, Dongryeol Ryu, Hyun Joo Lee, Jongkil Joo, Ki-Tae Ha
Summary: Endometriosis is a common gynecological disease, and its underlying mechanisms are not fully understood. This study identified differentially expressed genes associated with endometriosis and revealed multiple signaling pathways involved in its pathogenesis. Validation of gene expression was also done through immunohistochemistry and western blot analysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Roya Ahmadi, Bakhtyar Sepehri, Mehdi Irani, Raouf Ghavami
Summary: In this study, structure-based drug design methods were used to optimize carbamazepine (CBZ) for enhanced binding capacity to the N6W binding site of FZD8. Two compounds, 79 and 82, showed the smallest binding energies to the N6W binding site. Compounds C79 and C82 were synthesized by replacing a hydrogen atom of the seven-membered ring in CBZ with benzoate and nicotinate groups, respectively. Docking results also indicated that a trifluoromethyl on one of the phenyl rings was favorable for improving the FZD8 inhibition activity of the molecule. Molecular dynamics simulation showed that the FZD8-C82 complex was stable and had stronger binding to the N6W binding site compared to C79 and CBZ.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Medicine, General & Internal
Grzegorz Grzesk, Wioleta Stolarek, Michal Kasprzak, Elzbieta Grzesk, Daniel Rogowicz, Michal Wicinski, Marek Krzyzanowski
Summary: The retrospective analysis of 710 patients treated with Carbamazepine revealed that patients between 3 and 17 years of age were more likely to be within the therapeutic range, despite receiving higher doses per kilogram of body weight. Patients aged ≥18 were more likely to experience drug overdose, while suicide attempts only occurred in elderly patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Safaa A. Faheem, Reem M. Hazem, Norhan M. Elsayed, Yasser M. Ahmed, Noha M. Saeed
Summary: The study aimed to assess the involvement of Wnt/beta-catenin signaling in CsA-induced hepatotoxicity and whether knockdown of this pathway by NCL can attenuate CsA-induced hepatotoxicity. The results showed that NCL can significantly decrease liver enzymes activities, improve histopathological alterations induced by CsA, alleviate oxidative stress and inflammation. Moreover, NCL inhibited Wnt/beta-catenin signaling and increased the expression of PPAR-gamma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shaoqin Zheng, Jiahui Lin, Zhongqiu Pang, Hui Zhang, Yinuo Wang, Lanjing Ma, Haijiao Zhang, Xi Zhang, Maorong Chen, Xinjun Zhang, Chao Zhao, Jun Qi, Liu Cao, Min Wang, Xi He, Ren Sheng
Summary: In this study, researchers discovered that cholesterol binds specifically to the Fzd5 receptor, enabling its maturation and trafficking to the plasma membrane. Cholesterol stimulates tumor growth in Wnt-addicted pancreatic ductal adenocarcinoma through Fzd5-mediated signaling, while a natural compound can inhibit this process. These findings reveal a novel mechanism by which Fzd5 acts as a cholesterol sensor and suggest potential therapeutic opportunities for Wnt-dependent cancers.
Article
Biophysics
Hannes Schihada, Maria Kowalski-Jahn, Ainoleena Turku, Gunnar Schulte
Summary: This study developed fluorescence-based biosensors that detect WNT-induced FZD conformational changes in living cells, revealing the selectivity of WNTs to their receptors and distinct ligand-induced receptor conformations.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Medicine, General & Internal
Yoko Urashima, Honami Kobayashi, Kana Yamamoto, Kazuki Matsushita, Kazuya Urashima, Masahiko Tsujikawa, Kaoru Suzuki, Kazumi Kurachi, Masami Nishihara, Masashi Neo, Michiaki Myotoku, Takuro Kobori, Tokio Obata
Summary: Co-administration of CBZ with Ensure Liquid (R) reduces the absorption of CBZ from the gastrointestinal tract without adsorption on the NG tube. Giving Ensure Liquid (R) 2 hours after CBZ administration prevents a decrease in plasma CBZ concentration.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Weixuan Zhao, Hongmei Meng
Summary: This article introduces the impact of epilepsy as a chronic brain disease on nearly 50 million people worldwide. Traditional antiepileptic drugs have various problems, and although new drugs have partially solved these issues, they cannot completely replace traditional drugs in clinical applications. Therefore, it is still important to continue using traditional antiepileptic drugs with individualized therapeutic plans.
Article
Clinical Neurology
Samantha E. Stilley, Akshay S. Naraine, Krishna P. Yadavalli, Samantha L. Maki, Elyse M. Jutte, Jared M. Kahn, Alexis A. Surtel, Salvatore D. Lepore, Ken Dawson-Scully
Summary: In this study, a new class of small-molecule synthetic compounds that can ameliorate seizure-like behavior was described. The electroshock assay in Caenorhabditis elegans was used to examine seizure duration and determine that these compounds, called resveramorphs, act through an irreversible binding mechanism.
Article
Microbiology
Soma Mandal, Tanya Parish
Summary: The benzoxaborole series has shown antimicrobial activity against Escherichia coli, with resistant mutants showing mutations in the enoyl acyl carrier protein FabI. The physical interaction between benzoxaborole and FabI is dependent on the cofactor NAD(+), providing further scope for development against Gram-negative pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Richi Sakaguchi, Saki Nakamura, Hiroyuki Iha, Masaki Tanaka
Summary: Currently, in vitro phenotypic screening methods are widely used for drug discovery. In the field of epilepsy research, measurements of neuronal activities have been utilized for predicting efficacy of anti-epileptic drugs. Researchers have developed a high-throughput screening system with a new analysis method for quantifying waveforms, allowing simultaneous measurement of calcium oscillations in a 96-well plate. The characterization of anti-epileptic drugs and prediction of novel drug candidates' mechanism of action can be achieved by focusing on the features of calcium oscillations using principal component analysis.
Article
Chemistry, Physical
Erich Hellemann, Jacob D. Durrant
Summary: Structure-based virtual screening is effective for identifying potential small-molecule ligands. However, traditional approaches struggle to find ligands that bind to alternate conformations. Ensemble docking addresses this issue but requires methods to thoroughly explore pocket flexibility. We introduce Sub-Pocket EXplorer (SubPEx), which uses weighted ensemble path sampling to accelerate binding-pocket sampling.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Behavioral Sciences
Jane Adams, Patricia Ann Janulewicz, Eric A. Macklin, Ruby Dhillon, Catherine Phillips, Donald L. Schomer, William A. Tosches, Jeffrey M. Carlson, Lewis B. Holmes
Summary: The study results show that prenatal exposure to phenobarbital may have negative effects on children's mental abilities, especially in verbal IQ and full-scale IQ. Compared to other drug groups, children exposed to PB had lower verbal and full-scale IQ scores, but there were no significant differences in the performance of children exposed to CBZ compared to those exposed to PB or PHT.
EPILEPSY & BEHAVIOR
(2022)
Review
Chemistry, Analytical
Hugo Baali, Claudia Cosio
Summary: Carbamazepine (CBZ), a common pharmaceutical in the aquatic environment, has various effects on aquatic animals, including ROS homeostasis, neuroendocrine system, cell viability, immunity, reproduction, feeding behavior, and growth. CBZ affects acetylcholinesterase activity at low concentrations and triggers ROS production and cellular stress at higher concentrations. The response to CBZ is species-, organ-, and time-dependent and influenced by experimental conditions and animal origin.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2022)
Article
Immunology
Nicole A. Mifsud, Patricia T. Illing, Jeffrey W. Lai, Heidi Fettke, Luca Hensen, Ziyi Huang, Jamie Rossjohn, Julian P. Vivian, Patrick Kwan, Anthony W. Purcell
Summary: This study investigated the impact of antiseizure medications on T cells in patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). The research found that CBZ-reactive memory T cells require both the drug and HLA-B*15:02 for activation, resulting in a focused private TCR profile upon reactivation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Piyada Supasa, Daming Zhou, Wanwisa Dejnirattisai, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M. E. Duyvesteyn, Rungtiwa Nutalai, Aekkachai Tuekprakhon, Beibei Wang, Guido C. Paesen, Jose Slon-Campos, Cesar Lopez-Camacho, Bassam Hallis, Naomi Coombes, Kevin R. Bewley, Sue Charlton, Thomas S. Walter, Eleanor Barnes, Susanna J. Dunachie, Donal Skelly, Sheila F. Lumley, Natalie Baker, Imam Shaik, Holly E. Humphries, Kerry Godwin, Nick Gent, Alex Sienkiewicz, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Paul Klenerman, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah Gilbert, David R. Hall, Mark A. Williams, Neil G. Paterson, William James, Miles W. Carroll, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: Research on the UK-dominant variant B.1.1.7 shows that it is harder to neutralize than the parental virus, but widespread escape from antibodies or monoclonal antibodies has not been observed yet.
Article
Biochemistry & Molecular Biology
Wanwisa Dejnirattisai, Daming Zhou, Helen M. Ginn, Helen M. E. Duyvesteyn, Piyada Supasa, James Brett Case, Yuguang Zhao, Thomas S. Walter, Alexander J. Mentzer, Chang Liu, Beibei Wang, Guido C. Paesen, Jose Slon-Campos, Cesar Lopez-Camacho, Natasha M. Kafai, Adam L. Bailey, Rita E. Chen, Baoling Ying, Craig Thompson, Jai Bolton, Alex Fyfe, Sunetra Gupta, Tiong Kit Tan, Javier Gilbert-Jaramillo, William James, Michael Knight, Miles W. Carroll, Donal Skelly, Christina Dold, Yanchun Peng, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Paul Klenerman, Nigel Temperton, David R. Hall, Mark A. Williams, Neil G. Paterson, Felicity K. R. Bertram, C. Alistair Siebert, Daniel K. Clare, Andrew Howe, Julika Radecke, Yun Song, Alain R. Townsend, Kuan-Ying A. Huang, Elizabeth E. Fry, Juthathip Mongkolsapaya, Michael S. Diamond, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: Antibodies play a crucial role in immune protection against SARS-CoV-2, with some being used as therapeutics. A study identified 377 human monoclonal antibodies, focusing on 80 that bind the virus spike, and found that most highly inhibitory antibodies can block the virus-receptor interaction. Novel binding modes of potent inhibitory antibodies were discovered, showing potential for prophylactic or therapeutic use in animal models.
Article
Biochemistry & Molecular Biology
Daming Zhou, Wanwisa Dejnirattisai, Piyada Supasa, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M. E. Duyvesteyn, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Guido C. Paesen, Cesar Lopez-Camacho, Jose Slon-Campos, Bassam Hallis, Naomi Coombes, Kevin Bewley, Sue Charlton, Thomas S. Walter, Donal Skelly, Sheila F. Lumley, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah Gilbert, William James, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.
Article
Endocrinology & Metabolism
Yuguang Zhao, Laura-Nadine Schuhmacher, Morgan Roberts, Satoshi Kakugawa, Ganka Bineva-Todd, Steve Howell, Nicola O'Reilly, Christine Perret, Ambrosius P. Snijders, Jean-Paul Vincent, E. Yvonne Jones
Summary: The study demonstrates that Notum can act as a ghrelin deacylase, with physiological relevance under high-fat diet conditions. Liver-specific inactivation of Notum leads to a significant increase in acylated ghrelin in circulation under high-fat diet conditions.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Wanwisa Dejnirattisai, Daming Zhou, Piyada Supasa, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M. E. Duyvesteyn, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Cesar Lopez-Camacho, Jose Slon-Campos, Thomas S. Walter, Donal Skelly, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah C. Gilbert, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Neil G. Paterson, Mark A. Williams, David R. Hall, Ruben J. G. Hulswit, Thomas A. Bowden, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: Ending the SARS-CoV-2 pandemic requires global vaccination. New virus strains with mutations impact antibody responses, but some variants are less resistant than others. A monoclonal antibody can neutralize different variants and partially restore neutralization potency for other public antibodies.
Article
Biochemistry & Molecular Biology
Wanwisa Dejnirattisai, Jiandong Huo, Daming Zhou, Jiri Zahradnik, Piyada Supasa, Chang Liu, Helen M. E. Duyvesteyn, Helen M. Ginn, Alexander J. Mentzer, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Aiste Dijokaite, Suman Khan, Ori Avinoam, Mohammad Bahar, Donal Skelly, Sandra Adele, Sile Ann Johnson, Ali Amini, Thomas G. Ritter, Chris Mason, Christina Dold, Daniel Pan, Sara Assadi, Adam Bellass, Nicola Omo-Dare, David Koeckerling, Amy Flaxman, Daniel Jenkin, Parvinder K. Aley, Merryn Voysey, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Vicky Baillie, Natali Serafin, Gaurav Kwatra, Kelly Da Silva, Shabir A. Madhi, Marta C. Nunes, Tariq Malik, Peter J. M. Openshaw, J. Kenneth Baillie, Malcolm G. Semple, Alain R. Townsend, Kuan-Ying A. Huang, Tiong Kit Tan, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Bede Constantinides, Hermione Webster, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Gideon Schreiber, David Stuart, Gavin R. Screaton
Summary: On November 24, 2021, the sequence of a new SARS-CoV-2 variant, Omicron-B.1.1.529, was announced. Compared to previous variants, Omicron has a higher number of mutations in the Spike (S) protein. Serum neutralization of Omicron by individuals vaccinated or previously infected with Alpha, Beta, Gamma, or Delta variants is significantly reduced or ineffective. Third vaccine doses can boost neutralization titers against Omicron, and high titers are observed in both vaccinated individuals and those infected with the Delta variant. Most potent monoclonal antibodies and antibodies under development are unable to effectively neutralize Omicron due to mutations in its Spike protein. Omicron has structural changes compared to earlier viruses and utilizes mutations that enhance its binding to ACE2, allowing for immune escape. This results in a large number of mutations in the ACE2 binding site and a rebalancing of receptor affinity similar to earlier pandemic viruses.
Article
Microbiology
Chang Liu, Daming Zhou, Rungtiwa Nutalai, Helen M. E. Duyvesteyn, Aekkachai Tuekprakhon, Helen M. Ginn, Wanwisa Dejnirattisai, Piyada Supasa, Alexander J. Mentzer, Beibei Wang, James Brett Case, Yuguang Zhao, Donal T. Skelly, Rita E. Chen, Sile Ann Johnson, Thomas G. Ritter, Chris Mason, Tariq Malik, Nigel Temperton, Neil G. Paterson, Mark A. Williams, David R. Hall, Daniel K. Clare, Andrew Howe, Philip J. R. Goulder, Elizabeth E. Fry, Michael S. Diamond, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: This study investigated several variants of SARS-CoV-2 and found that the Beta variant has the largest antigenic difference compared to other variants, such as Delta, and is poorly neutralized by serum from early pandemic and Delta viruses. The study also revealed that certain antibodies can recognize conserved neutralizing epitopes, while others target specific mutated residues in the Beta variant.
CELL HOST & MICROBE
(2022)
Article
Chemistry, Medicinal
David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul Fish, Fredrik Svensson
Summary: Notum has been identified as a negative regulator of the Wnt signaling pathway, and inhibitors targeting it may have therapeutic potential for diseases with dysfunctional Notum activity. A virtual screening approach successfully shortlisted 952 compounds as potential Notum inhibitors, with 31 compounds showing promising activity in experimental validations.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Kuan-Ying A. Huang, Daming Zhou, Tiong Kit Tan, Charles Chen, Helen M. E. Duyvesteyn, Yuguang Zhao, Helen M. Ginn, Ling Qin, Pramila Rijal, Lisa Schimanski, Robert Donat, Adam Harding, Javier Gilbert-Jaramillo, William James, Julia A. Tree, Karen Buttigieg, Miles Carroll, Sue Charlton, Chia-En Lien, Meei-Yun Lin, Cheng-Pin Chen, Shu-Hsing Cheng, Xiaorui Chen, Tzou-Yien Lin, Elizabeth E. Fry, Jingshan Ren, Che Ma, Alain R. Townsend, David Stuart
Summary: The study reveals that representative antibodies targeting non-overlapping epitopes are effective against wild type virus and emerging variants. The neutralization is associated with the inhibition of viral RBD binding to ACE2. Structural analysis shows that these antibodies have unique features while sharing some similarities with previously reported neutralizing monoclonal antibodies.
Article
Biochemistry & Molecular Biology
Rungtiwa Nutalai, Daming Zhou, Aekkachai Tuekprakhon, Helen M. Ginn, Piyada Supasa, Chang Liu, Jiandong Huo, Alexander J. Mentzer, Helen M. E. Duyvesteyn, Aiste Dijokaite-Guraliuc, Donal Skelly, Thomas G. Ritter, Ali Amini, Sagida Bibi, Sandra Adele, Sile Ann Johnson, Bede Constantinides, Hermione Webster, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Philip Goulder, Neil G. Paterson, Mark A. Williams, David R. Hall, Juthathip Mongkolsapaya, Elizabeth E. Fry, Wanwisa Dejnirattisai, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: This study compares the neutralization of Omicron variants of SARS-CoV-2 and finds that differences in neutralization mostly arise from variations in residues bordering the ACE2 binding site. Analysis of monoclonal antibodies isolated from vaccinated individuals shows that they can effectively neutralize early pandemic strains and exhibit broad reactivity with variants.
Article
Chemistry, Medicinal
Nicky J. Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L. Woodward, Benjamin N. Atkinson, Elliott D. Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnu, Sarah Jolly, Luca Vecchia, Reinis R. Ruza, Svend Kjaer, Steven Howell, Ambrosius P. Snijders, Magda Bictash, Patricia C. Salinas, Jean-Paul Vincent, E. Yvonne Jones, Paul Whiting, Paul Fish
Summary: Notum functions as a crucial enzyme in human diseases such as colorectal cancer and Alzheimer's disease. The discovery of 8l as a potent, selective, and brain-penetrant inhibitor of Notum activity suitable for oral dosing in rodent models of disease marks a significant progress in developing improved inhibitors for neurodegenerative diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yuguang Zhao, William Mahy, Nicky J. Willis, Hannah L. Woodward, David Steadman, Elliott D. Bayle, Benjamin N. Atkinson, James Sipthorp, Luca Vecchia, Reinis R. Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjaer, Magda Bictash, Patricia C. Salinas, Paul Whiting, Jean-Paul Vincent, Paul Fish, E. Yvonne Jones
Summary: Notum is a promising target for treating osteoporosis, Alzheimer's disease, and colorectal cancer. Through fragment screening and optimization, researchers have obtained a series of potential Notum inhibitors.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Aekkachai Tuekprakhon, Rungtiwa Nutalai, Aiste Dijokaite-Guraliuc, Daming Zhou, Helen M. Ginn, Muneeswaran Selvaraj, Chang Liu, Alexander J. Mentzer, Piyada Supasa, Helen M. E. Duyvesteyn, Raksha Das, Donal Skelly, Thomas G. Ritter, Ali Amini, Sagida Bibi, Sandra Adele, Sile Ann Johnson, Bede Constantinides, Hermione Webster, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Philip Goulder, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Jiandong Huo, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: The Omicron variant of SARS-CoV-2 has rapidly spread globally and has evolved into different sublineages, with BA.4 and BA.5 dominating in South Africa. These sublineages show reduced neutralization by vaccine and naturally immune serum, indicating the possibility of repeat Omicron infections.
Article
Virology
Daming Zhou, Ling Qin, Helen M. E. Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E. Fry, Jingshan Ren, Kuan-Ying A. Huang, David I. Stuart
Summary: This study presents the structure and interaction mechanism between E11 virus and DAF, providing important insights into the infection process of E11 virus and potential targets for drug and vaccine development.
Article
Biology
Ronggang Song, Jing Ren, Junxia Sun, Ming Li
Summary: The combination of melatonin postconditioning and sitagliptin pretreatment significantly reduces myocardial ischemia-reperfusion injury in diabetic aged rats by modulating oxidative stress, apoptosis, and the AMPK/SIRT1 pathway, showcasing a potential central mechanism for cardioprotection.
ARCHIVES OF BIOLOGICAL SCIENCES
(2021)
