Article
Biology
Andrew M. Hamilton, Olga A. Balashova, Laura N. Borodinsky
Summary: Research indicates that Hedgehog (Hh) signaling may be a useful target for driving regeneration, and non-canonical mechanisms of Hh signaling are necessary for spinal cord and muscle regeneration.
Article
Developmental Biology
Eva Janeckova, Jifan Feng, Tingwei Guo, Xia Han, Aileen Ghobadi, Angelita Araujo-Villalba, Md Shaifur Rahman, Heliya Ziaei, Thach-Vu Ho, Siddhika Pareek, Jasmine Alvarez, Yang Chai
Summary: This study reveals the crucial role of Wnt signaling in soft palate development and muscle differentiation through the regulation of ciliary homeostasis. Wnt signaling activates ciliary gene Ttll3 expression, which is necessary for mesenchymal cell proliferation and subsequent myogenesis.
Review
Cell Biology
Ian James Bell, Matthew Sheldon Horn, Terence John Van Raay
Summary: The non-canonical Wnt signaling pathways have different roles in cancer and development, involving calcium and Vangl2. Cells tend to choose non-canonical Wnt signaling over canonical Wnt signaling when presented with a choice, but this occurs rarely in vivo.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Sheng Zhang, Yan Wang, Jie Xu, Bokyung Kim, Wenbin Deng, Fuzheng Guo
Summary: This study reveals the important role of HIF-alpha in developmental myelination, demonstrating its requirement in controlling OPC differentiation for efficient myelination. Contrary to previous beliefs, it was found that HIF-alpha's regulation of CNS myelination is independent of canonical Wnt signaling, and instead involves the HIF-alpha-Sox9 regulatory axis. This discovery represents a shift in understanding the mechanisms of HIF-alpha-regulated CNS myelination from a Wnt-dependent view to a Wnt-independent one.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Jessica Schaefer, Nicole Wenck, Katharina Janik, Joshua Linnert, Katarina Stingl, Susanne Kohl, Kerstin Nagel-Wolfrum, Uwe Wolfrum
Summary: Human Usher syndrome (USH) is a complex genetic disorder that causes combined deafness and blindness. The underlying mechanisms of the disease, particularly in the eye and retina, are not well understood. This study identifies a role for the scaffold protein harmonin, encoded by the USH1C gene, in regulating the canonical Wnt/beta-catenin signaling pathway. The findings suggest that USH1C/harmonin acts as a suppressor of the pathway, and dysregulation of this pathway may contribute to the development of USH.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Andre Landin Malt, Shaylyn Clancy, Diane Hwang, Alice Liu, Connor Smith, Margaret Smith, Maya Hatley, Christopher Clemens, Xiaowei Lu
Summary: A non-canonical Wnt signaling pathway has been found to promote cochlear outgrowth and coordinate planar polarization of hair cells. Gsk3 beta and Rac1 play crucial roles in this pathway, as shown in genetic rescue experiments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bindu Chandrasekharan, Claudia Montllor-Albalate, Alyson E. Colin, Joshua L. Andersen, Young C. Jang, Amit R. Reddi
Summary: Cu/Zn superoxide dismutase (Sod1) catalyzes the breakdown of superoxide radicals into oxygen and hydrogen peroxide, which acts as a signaling molecule. In yeast, Sod1 is involved in a redox signaling pathway that connects nutrient availability to energy metabolism control. This pathway stabilizes plasma membrane kinases Yck1/2, promoting glycolytic growth and repressing respiration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Jinzhi He, Junjun Jing, Jifan Feng, Xia Han, Yuan Yuan, Tingwei Guo, Fei Pei, Yuanyuan Ma, Courtney Cho, Thach-Vu Ho, Yang Chai
Summary: The number of tooth roots is finely regulated in mammalian dentition, with Lhx6 playing a key role in determining molar root number by controlling the region-specific fate determination of progenitor cells. Loss of Lhx6 leads to root patterning defects, indicating its importance in organ morphogenesis and future tooth root regeneration strategies.
Article
Multidisciplinary Sciences
Nicola Alesi, Elie W. Akl, Damir Khabibullin, Heng-Jia Liu, Anna S. Nidhiry, Emma R. Garner, Harilaos Filippakis, Hilaire C. Lam, Wei Shi, Srinivas R. Viswanathan, Manrico Morroni, Shawn M. Ferguson, Elizabeth P. Henske
Summary: Despite the high mTORC1 activity in TSC, TFEB is found to localize to the nucleus and drive lysosomal gene expression via a non-canonical Rag-dependent mechanism. The TSC proteins are established as critical regulators of lysosomal biogenesis through TFEB and RAGC, and TFEB is identified as a driver of the proliferation of TSC2-deficient cells.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Melanie Piller, Inge L. Werkman, Evan A. Brown, Andrew J. Latimer, Sarah Kucenas
Summary: The study found that the ionotropic glutamate receptor subunit GluR4A plays a crucial role in OPC migration and myelination, disruption of which leads to abnormal migration and distribution of OPCs in the spinal cord. Through genetic and pharmacological experiments, it was discovered that voltage-gated calcium channels are downstream of glutamate receptor signaling in OPCs and can rescue migration and myelination defects caused by disrupted glutamate signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Derek Avery, Lais Morandini, Luke S. Sheakley, Arth H. Shah, Loc Bui, Jefferson O. Abaricia, Rene Olivares-Navarrete
Summary: This study investigates the role of canonical Wnt signaling in the response of macrophages to titanium surface properties. The results show that activating canonical Wnt signaling promotes a pro-inflammatory phenotype, while inhibiting it enhances an anti-inflammatory response.
Article
Chemistry, Medicinal
Mengjiao Shi, Jian Zhang, Miaomiao Li, Yaping Zhao, Ying Guo, Jiayi Xu, Rongrong Liu, Zongfang Li, Dongmei Ren, Pengfei Liu
Summary: This study investigated the protective effects of liquiritigenin (LQ), a natural flavonoid, against oxidative hepatotoxicity and the underlying mechanism. It was found that LQ eliminated reactive oxygen species in liver cells through NRF2 activation, involving both canonical and non-canonical signaling pathways. LQ-induced NRF2 activation was partially dependent on KEAP1-C151 and was also mediated by the blockage of autophagic flux and upregulation of p62, which competitively bound with KEAP1. Overall, this study reveals a novel molecular mechanism underlying the hepatoprotection of LQ, providing new insights into the pathogenesis and therapeutic strategies for oxidative liver injury.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Chatvadee Kornsuthisopon, Ajjima Chansaenroj, Jeeranan Manokawinchoke, Kevin A. Tompkins, Nopadon Pirarat, Thanaphum Osathanon
Summary: This study found that Jagged1 promoted osteo/odontogenic differentiation of human dental pulp stem cells (hDPSCs) by modulating the non-canonical Wnt pathway.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yinhua Jin, Teni Anbarchian, Peng Wu, Abby Sarkar, Matt Fish, Weng Chuan Peng, Roel Nusse
Summary: Cell proliferation is tightly regulated by various factors, including transcriptional repressors E2F7 and E2F8. In this study, it was discovered that Wnt/β-catenin signaling maintains active cell division in the liver through the transcription factor Tbx3. Tbx3 directly represses the transcription of E2f7 and E2f8, thereby promoting mitosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Yuan Xie, Liqun He, Yanyu Zhang, Hua Huang, Fan Yang, Min Chao, Haiyan Cao, Jianhao Wang, Yaling Li, Lingxue Zhang, Lele Xin, Bing Xiao, Xinxin Shi, Xue Zhang, Jiefu Tang, Lene Uhrbom, Anna Dimberg, Liang Wang, Lei Zhang
Summary: Inhibiting the Wnt signaling pathway can increase Temozolomide (TMZ) delivery and sensitize glioma to chemotherapy. Transcriptome analysis revealed that Wnt signaling inhibition enhances vascular transcytosis by upregulating PLVAP and downregulating MFSD2A. Additionally, Wnt signaling inhibition also enhances caveolae-mediated transcytosis in tumor endothelial cells (ECs). These findings suggest that Wnt signaling regulates MFSD2A-dependent TMZ delivery through a caveolae-mediated pathway, highlighting Wnt signaling as a promising therapeutic target for GBM treatment.
Article
Biochemistry & Molecular Biology
Minsun Kim, Eun-hee Kim, Bo-Ran Choi, Hee-Jong Woo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Veterinary Sciences
Tracy Stokol, Janelle L. Daddona, Boran Choi
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Bo-Ran Choi, Jeongmin Lee, Su Yeon Kim, Inbeen Yim, Eun-Hee Kim, Hee-Jong Woo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2013)
Article
Neurosciences
Steven E. Arnold, Irwin Lucki, Bethany R. Brookshire, Gregory C. Carlson, Caroline A. Browne, Hala Kazi, Sookhee Bang, Bo-Ran Choi, Yong Chen, Mary F. McMullen, Sangwon F. Kim
NEUROBIOLOGY OF DISEASE
(2014)
Article
Neurosciences
B. -R. Choi, S. Bang, Y. Chen, J. H. Cheah, S. F. Kim
Article
Cell Biology
Mai Nakamura, Yuhan Li, Bo-Ran Choi, Elisa Matas-Rico, Juan Troncoso, Chiaki Takahashi, Shanthini Sockanathan
Summary: The study highlights the essential role of GDE2 in controlling RECK surface activity for ADAM10 alpha-secretase function and physiological APP processing. Reduction of RECK restores the balance of APP processing and rescues synaptic protein deficits, suggesting the involvement of the GDE2-RECK-ADAM10 pathway in AD pathophysiology and emphasizing RECK as a potential target for therapeutic development in Alzheimer's disease.
SCIENCE TRANSLATIONAL MEDICINE
(2021)