P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers

Prostate-specific antigen dynamics predict individual responses to intermittent androgen deprivation

(2020) Renee Brady-Nicholls et al.   Nature Communications

Integrating evolutionary dynamics into cancer therapy

(2020) Robert A. Gatenby et al.   Nature Reviews Clinical Oncology

Control of metabolism by p53 – Cancer and beyond

(2018) Christiaan F. Labuschagne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting pattern-recognition receptors to discover new small molecule immune modulators

(2018) Gengzheng Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

(2018) Kristian M. Hargadon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors

(2018) Milan Hano et al.   MOLECULES

JNK-AKT-NF-κB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells

(2018) Xiaoming Li et al.   BIOCHEMICAL PHARMACOLOGY

MDR1 in immunity: friend or foe?

(2018) Marion Bossennec et al.   OncoImmunology

Overcoming P-Glycoprotein–Mediated Drug Resistance with Noscapine Derivatives

(2018) Divya Muthiah et al.   DRUG METABOLISM AND DISPOSITION

Ferulic acid reverses P-glycoprotein-mediated multidrug resistance via inhibition of PI3K/Akt/NF-κB signaling pathway

(2018) Ganesan Muthusamy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Emerging roles of lipid metabolism in cancer metastasis

(2017) Xiangjian Luo et al.   Molecular Cancer

PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways

(2017) Shengwei Liu et al.   Oncotarget

Increased PD-L1 expression and IL-6 secretion characterize human lung tumor-derived perivascular-like cells that promote vascular leakage in a perfusable microvasculature model

(2017) Colette A. Bichsel et al.   Scientific Reports

Unidirectional Transport Mechanism in an ATP Dependent Exporter

(2017) Yanyan Xu et al.   ACS Central Science

The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code

(2017) Milica Vučetić et al.   Frontiers in Oncology

Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein

(2016) Eduardo E. Chufan et al.   BIOCHEMICAL PHARMACOLOGY

Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy

(2016) Fang Chen et al.   JOURNAL OF IMMUNOLOGICAL METHODS

PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas

(2016) Aaron Goodman et al.   Nature Reviews Clinical Oncology

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians

(2016) J Vendelbo et al.   PHARMACOGENOMICS JOURNAL

Targeting P-glycoprotein expression and cancer cell energy metabolism: combination of metformin and 2-deoxyglucose reverses the multidrug resistance of K562/Dox cells to doxorubicin

(2016) Chaojun Xue et al.   TUMOR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

(2016) Petr Pavek   Frontiers in Pharmacology

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

(2016) Mi Park et al.   Cells

Allocrite Sensing and Binding by the Breast Cancer Resistance Protein (ABCG2) and P-Glycoprotein (ABCB1)

(2015) Yanyan Xu et al.   BIOCHEMISTRY

Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics

(2015) N A Seebacher et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Human P-Glycoprotein Transporter Enhances the Type I Interferon Response to Listeria monocytogenes Infection

(2015) Nadejda Sigal et al.   INFECTION AND IMMUNITY

Possible Immunosuppressive Effects of Drug Exposure and Environmental and Nutritional Effects on Infection and Vaccination

(2015) H. P. Huemer   MEDIATORS OF INFLAMMATION

Predicting Activators and Inhibitors of the Breast Cancer Resistance Protein (ABCG2) and P-Glycoprotein (ABCB1) Based on Mechanistic Considerations

(2015) Estefanía Egido et al.   MOLECULAR PHARMACEUTICS

Aspirin Decreases Systemic Exposure to Clopidogrel Through Modulation of P-Glycoprotein But Does Not Alter Its Antithrombotic Activity

(2014) J Oh et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle

(2014) Joseph K. Zolnerciks et al.   FASEB JOURNAL

ADMET Evaluation in Drug Discovery. 13. Development of in Silico Prediction Models for P-Glycoprotein Substrates

(2014) Dan Li et al.   MOLECULAR PHARMACEUTICS

Tyrosine Kinase Inhibitors as Reversal Agents for ABC Transporter Mediated Drug Resistance

(2014) Nagaraju Anreddy et al.   MOLECULES

HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein

(2014) Jianfang Chen et al.   PLoS One

P-glycoprotein ABCB1: a major player in drug handling by mammals

(2013) Piet Borst et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

(2013) Eduardo E. Chufan et al.   PLoS One

Cancer drug discovery by repurposing: teaching new tricks to old dogs

(2013) Subash C. Gupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

How hydrogen bonds impact P-glycoprotein transport and permeability

(2012) Prashant V. Desai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

P-Glycoprotein-ATPase Modulation: The Molecular Mechanisms

(2012) Xiaochun Li-Blatter et al.   BIOPHYSICAL JOURNAL

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Regulation of lipid metabolism by p53 – fighting two villains with one sword

(2012) Ido Goldstein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The controversial role of ABC transporters in clinical oncology

(2011) Akina Tamaki et al.   Essays in Biochemistry

ABC transporters, mechanisms and biology: an overview

(2011) I. Barry Holland   Essays in Biochemistry

Cytokines in Cancer Immunotherapy

(2011) Sylvia Lee et al.   Cancers

A novel in vivo regulatory role of P-glycoprotein in alloimmunity

(2010) Atsushi Izawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exploring the P-Glycoprotein Binding Cavity with Polyoxyethylene Alkyl Ethers

(2010) Xiaochun Li-Blatter et al.   BIOPHYSICAL JOURNAL

Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation

(2010) Hyung Gyun Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Zhanglin Ni et al.   CURRENT DRUG METABOLISM

Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide

(2009) Joost W. van der Heijden et al.   ARTHRITIS AND RHEUMATISM

Detergents as intrinsic P-glycoprotein substrates and inhibitors

(2009) Xiaochun Li-Blatter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib

(2009) Henk J. Broxterman et al.   DRUG RESISTANCE UPDATES

Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock

(2009) Elżbieta Wyska   INTERNATIONAL IMMUNOPHARMACOLOGY

T lymphocytes impair P-glycoprotein function during neuroinflammation

(2009) Gijs Kooij et al.   JOURNAL OF AUTOIMMUNITY

ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer

(2009) Rieneke van de Ven et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

(2009) Guido Zibell et al.   NEUROPHARMACOLOGY

P-Glycoprotein Acts as an Immunomodulator during Neuroinflammation

(2009) Gijs Kooij et al.   PLoS One

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Comparative effects of drugs on P-glycoprotein expression and activity using rat and human trophoblast models

(2009) D. Beghin et al.   TOXICOLOGY IN VITRO

Targeting P-glycoprotein for Effective Oral Anti-Cancer Chemotherapeutics

(2008) M. Bebawy et al.   CURRENT CANCER DRUG TARGETS

Structural insights into ABC transporter mechanism

(2008) Michael L Oldham et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY