HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein

Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo

(2012) Min Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects

(2011) Puja Sapra et al.   ANGIOGENESIS

Hypoxia decreased chemosensitivity of breast cancer cell line MCF-7 to paclitaxel through cyclin B1

(2011) X.L. Dong et al.   BIOMEDICINE & PHARMACOTHERAPY

Mathematical Modeling Predicts Synergistic Antitumor Effects of Combining a Macrophage-Based, Hypoxia-Targeted Gene Therapy with Chemotherapy

(2011) M. R. Owen et al.   CANCER RESEARCH

Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy

(2011) Amit K. Tiwari et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Forced Expression of Heat Shock Protein 27 (Hsp27) Reverses P-Glycoprotein (ABCB1)-mediated Drug Efflux andMDR1Gene Expression in Adriamycin-resistant Human Breast Cancer Cells

(2011) Ragu Kanagasabai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T

(2011) Chantal H.M.A. Ramaekers et al.   RADIOTHERAPY AND ONCOLOGY

Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells

(2010) Zhenyu Ding et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Reversal of ABC Drug Transporter-Mediated Multidrug Resistance in Cancer Cells: Evaluation of Current Strategies

(2010) Chung-Pu Wu et al.   Current Molecular Pharmacology

Adhesion-mediated apoptosis resistance in cancer

(2009) Mike-Andrew Westhoff et al.   DRUG RESISTANCE UPDATES

Effect of HIF-1 modulation on the response of two- and three-dimensional cultures of human colon cancer cells to 5-fluorouracil

(2009) Raffaella Ravizza et al.   EUROPEAN JOURNAL OF CANCER

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis

(2009) Lavinia Nardinocchi et al.   Molecular Cancer

Effects of lentivirus-mediated HIF-1α knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells

(2008) J Hao et al.   CANCER GENE THERAPY

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

(2008) R. Sullivan et al.   MOLECULAR CANCER THERAPEUTICS