期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 95, 期 6, 页码 608-616出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2014.49
关键词
-
资金
- National Project for Personalized Genomic Medicine, Ministry for Health & Welfare, Republic of Korea [A111218-PG01]
- Korea Healthcare Technology Research and Development Project, Ministry for Health and Welfare of the Republic of Korea [A070001]
Decreased oral clopidogrel absorption caused by induction of intestinal permeability glycoprotein (P-gp) expression after aspirin administration was observed in rats. This study evaluated the effect of aspirin coadministration on the pharmacokinetics/pharmacodynamics of clopidogrel in humans. A single 75-mg dose of clopidogrel was orally administered before and after 2 and 4 weeks of once-daily 100-mg aspirin administration in 18 healthy volunteers who were recruited based on CYP2C19 and PON1 genotypes. Plasma concentrations of clopidogrel and its active metabolite, H4, and relative platelet inhibition (RPI) were determined. The P-gp microRNA miR-27a increased by up to 7.67-fold (P = 0.004) and the clopidogrel area under the concentration time curve (AUC) decreased by 14% (P > 0.05), but the AUC of H4 remained unchanged and RPI increased by up to 15% (P = 0.002) after aspirin administration.These findings indicate low-dose aspirin coadministration may decrease clopidogrel bioavailability but does not decrease its efficacy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据