期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1870, 期 1, 页码 32-42出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2018.06.001
关键词
-
资金
- Cancer Research UK [C596/A26855]
- Francis Crick Institute from Cancer Research UK
- UK Medical Research Council
- Wellcome Trust
p53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage - so preventing disease development. By contrast, either loss or over-activation of p53 can contribute to numerous metabolic pathologies, including aging, obesity and diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据