Article
Critical Care Medicine
Philipp Schultz, Elke Schwier, Claas Eickmeyer, Dietrich Henzler, Thomas Kohler
Summary: Hemoadsorption with CytoSorb(R) may be effective in improving survival in patients with septic shock, with blood purification volume exceeding 6 1/kgBW potentially playing a beneficial role in increasing survival.
JOURNAL OF CRITICAL CARE
(2021)
Article
Immunology
Huiming Tang, Shuang Qin, Zhanfei Li, Wei Gao, Manli Tang, Xijie Dong
Summary: This study investigates the early immune system changes in patients with septic shock. A total of 243 patients were included, classified as survivors or nonsurvivors. Tests were performed to examine immune system function. Neutrophil counts, infection biomarkers, and cytokines increased significantly in septic shock patients, while lymphocyte counts, immunoglobulin levels, and complement protein levels decreased. Nonsurvivors had higher levels of certain cytokines but lower levels of immunoglobulins and lymphocyte counts. Low immunoglobulin or complement concentrations and low lymphocyte or CD4+ T cell counts were independent risk factors for mortality.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Pedro Martinez-Paz, Marta Aragon-Camino, Esther Gomez-Sanchez, Mario Lorenzo-Lopez, Estefania Gomez-Pesquera, Alejandra Fadrique-Fuentes, Pilar Liu, Alvaro Tamayo-Velasco, Christian Ortega-Loubon, Marta Martin-Fernandez, Hugo Gonzalo-Benito, Emilio Garcia-Moran, Maria Heredia-Rodriguez, Eduardo Tamayo
Summary: The study aims to distinguish between septic shock and non-septic shock in postoperative patients through gene expression signature, providing personalized treatment and avoiding unnecessary antibiotic use and increased healthcare costs.
JOURNAL OF INFECTION
(2021)
Article
Endocrinology & Metabolism
Kai Zhang, Yang Wang, Shiyu Chen, Jiali Mao, Yue Jin, Hui Ye, Yan Zhang, Xiwang Liu, Chenchen Gong, Xuejun Cheng, Xiaoli Huang, Andreas Hoeft, Qixing Chen, Xuekun Li, Xiangming Fang
Summary: Sepsis-induced cardiomyopathy (SICM) is a common and highly fatal condition characterized by abnormal immune response. This study identifies a unique subpopulation of cardiac-resident macrophages, CD163(+)RETNLA(+) (Mac1), which play a crucial role in SICM and can be targeted for prevention. The study demonstrates that TREM2(hi) Mac1 cells actively scavenge dysfunctional mitochondria and their deficiency leads to impaired self-renewal capability, excessive inflammation, cardiac dysfunction, and reduced survival. Intrapericardial administration of TREM2(hi) Mac1 cells can prevent SICM, suggesting a potential therapeutic strategy.
Article
Medicine, General & Internal
Felipe Perez-Garcia, Salvador Resino, Esther Gomez-Sanchez, Hugo Gonzalo-Benito, Amanda Fernandez-Rodriguez, Mario Lorenzo-Lopez, Maria Heredia-Rodriguez, Estefania Gomez-Pesquera, Eduardo Tamayo, Maria Angeles Jimenez-Sousa
Summary: High expression of olfactomedin-4 (OLFM4) gene, regulated by nuclear factor-kappa B (NF-kappa B), is associated with increased risk of organ failure and death in patients with septic shock. Specific OLFM4 single nucleotide polymorphisms (SNPs) in patients who underwent major surgery are closely related to septic shock-related death risk. The combination of OLFM4 gene SNP and clinical variables can more accurately predict the clinical outcome of septic shock.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Chang-Gun Lee, Chanoh Park, Soonjae Hwang, Ju-Eun Hong, Minjeong Jo, Minseob Eom, Yongheum Lee, Ki-Jong Rhee
Summary: This study examined the effect of pulsed electromagnetic field (PEMF) therapy on a mouse model of lipopolysaccharide (LPS)-induced septic shock. The results showed that PEMF treatment increased the survival rate of mice and decreased pro-inflammatory cytokine gene expression and liver damage. Microarray analysis identified several genes regulated by PEMF therapy. Therefore, PEMF may be beneficial for patients with bacteria-induced sepsis and reduce septic shock-induced mortality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tapio Hellman, Panu Uusalo, Mikko J. Jaervisalo
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, leading to higher mortality risk compared to mere infection. Acute kidney injury (AKI) and renal replacement therapy (RRT) are major concerns in sepsis patients in intensive care units. Various techniques and devices have been explored to reduce inflammatory mediators and improve patient outcomes in septic shock, but the actual benefits remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Vasiliki Tsolaki, George E. Zakynthinos, John Papanikolaou, Vasileios Vazgiourakis, Kyriaki Parisi, George Fotakopoulos, Demosthenes Makris, Epaminondas Zakynthinos
Summary: This study compared the treatment of severe septic cardiomyopathy (SCM) with levosimendan and the best available therapy. The results showed that patients receiving levosimendan had better recovery of cardiac function and a decrease in lactate levels, although there was no statistically significant difference in survival rates. This suggests that levosimendan treatment may be effective in patients with severe SCM.
Article
Public, Environmental & Occupational Health
Yanyan Zhou, Chenfang Wu, Lin Ouyang, Ying Peng, Dingming Zhong, Xiaohong Xiang, Jinxiu Li
Summary: This study retrospectively reviewed the use of oXiris in septic shock and found that it improved hemodynamic indicators, reduced inflammation and lactate levels, and improved organ function, potentially resulting in higher survival rates.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Patrycja Lesnik, Lidia Lysenko, Malgorzata Krzystek-Korpacka, Ewa Woznica-Niesobska, Magdalena Mierzchala-Pasierb, Jaroslaw Janc
Summary: This study evaluated the usefulness of renin as a marker of tissue hypoperfusion in patients with sepsis and septic shock. The results showed that there was a significant difference in renin concentration between sepsis survivors and non-survivors, as well as between sepsis and septic shock patients. Renin, in combination with lactate concentration, seems to be the optimal parameter for monitoring tissue hypoperfusion and could be helpful for septic shock diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Felipe Perez-Garcia, Maria Angeles Jimenez-Sousa, Esther Gomez-Sanchez, Hugo Gonzalo-Benito, Amanda Fernandez-Rodriguez, Mario Lorenzo-Lopez, Maria Heredia-Rodriguez, Pedro Martinez-Paz, Estefania Gomez-Pesquera, Eduardo Tamayo, Salvador Resino
Summary: We conducted a retrospective exploratory study on patients who developed septic shock after major surgery, and found that polymorphisms in the CEACAM7 gene may influence the risk of septic shock-related death in these individuals.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Critical Care Medicine
Sam D. Hutchings, James Watchorn, Francesca Trovato, Salvatore Napoli, Salma F. Mujib, Philip Hopkins, Mark McPhail
Summary: In critically ill COVID-19 patients, there is less vasoactive drug requirement, lower plasma lactate levels, and no evidence of significant sublingual microcirculatory impairment, widespread endothelial injury, or marked inflammatory cytokine release compared to patients with septic shock. The hyperinflammatory response and organ failures seen in septic shock do not appear typical of COVID-19 infection.
Article
Emergency Medicine
Fei Xu, Rong Zhong, Shanyang Shi, Yiqian Zeng, Zhanhong Tang
Summary: Early initiation of norepinephrine in septic shock is associated with higher survival rates, shorter duration of supportive norepinephrine and invasive mechanical ventilation, and potential delay or reversal of rapid onset organ failure.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Critical Care Medicine
Jeremy Cohen, Antje Blumenthal, Gabriel Cuellar-Partida, David M. Evans, Simon Finfer, Qiang Li, Johanna Ljungberg, John Myburgh, Elizabeth Peach, Joseph Powell, Dorrilyn Rajbhandari, Andrew Rhodes, Anne Senabouth, Balasubramanian Venkatesh
Summary: In patients with septic shock, there is no association between adrenocortical candidate gene expression and mortality. Patients with higher expression of GLCCI1 who received hydrocortisone achieved shock resolution faster than those receiving placebo; conversely, patients who had higher expression of BHSD1 who received hydrocortisone achieved shock resolution slower than those who received placebo. Variation in gene expression may be a mechanism for heterogeneity of treatment response to corticosteroids in septic shock.
INTENSIVE CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Dachang Liu, Ziwei Hu, Jie Jiang, Junlei Zhang, Chunlong Hu, Jian Huang, Qingjun Wei
Summary: This study identifies biomarkers and therapeutic targets related to hypoxia and immunity in osteosarcoma through bioinformatics methods. A predictive model for the prognosis of osteosarcoma is established. The findings have significant implications for clinical diagnosis and treatment.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Ewa Poleszak, Sylwia Wosko, Karolina Slawinska, Elzbieta Wyska, Aleksandra Szopa, Jan Sobczynski, Andrzej Wrobel, Urszula Doboszewska, Piotr Wlaz, Aleksandra Wlaz, Jaroslaw Szponar, Piotr Skalecki, Anna Serefko
BEHAVIOURAL BRAIN RESEARCH
(2020)
Correction
Chemistry, Multidisciplinary
Artur Swierczek, Krzysztof Pociecha, Marietta Slusarczyk, Grazyna Chlon-Rzepa, Sebastian Bas, Jacek Mlynarski, Krzysztof Wieckowski, Monika Zadrozna, Barbara Nowak, Elzbieta Wyska
PHARMACEUTICAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Artur Swierczek, Krzysztof Pociecha, Marietta Slusarczyk, Grazyna Chlon-Rzepa, Sebastian Bas, Jacek Mlynarski, Krzysztof Wieckowski, Monika Zadrozna, Barbara Nowak, Elzbieta Wyska
PHARMACEUTICAL RESEARCH
(2020)
Article
Behavioral Sciences
Ewa Poleszak, Sylwia Wosko, Karolina Slawinska, Elzbieta Wyska, Aleksandra Szopa, Katarzyna Swiader, Andrzej Wrobel, Urszula Doboszewska, Piotr Wlaz, Aleksandra Wlaz, Anna Serefko
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Katarzyna Wojcik-Pszczola, Grazyna Chlon-Rzepa, Agnieszka Jankowska, Marietta Slusarczyk, Pawel E. Ferdek, Agnieszka A. Kusiak, Artur Swierczek, Krzysztof Pociecha, Paulina Koczurkiewicz-Adamczyk, Elzbieta Wyska, Elzbieta Pekala, Reinoud Gosens
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Medicinal
Agnieszka Jankowska, Grzegorz Satala, Marcin Kolaczkowski, Adam Bucki, Monika Gluch-Lutwin, Artur Swierczek, Krzysztof Pociecha, Anna Partyka, Magdalena Jastrzebska-Wiesek, Annamaria Lubelska, Gniewomir Latacz, Alicja Gawalska, Andrzej J. Bojarski, Elzbieta Wyska, Grazyna Chlon-Rzepa
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Joanna Sniecikowska, Monika Gluch-Lutwin, Adam Bucki, Anna Wieckowska, Agata Siwek, Magdalena Jastrzebska-Wiesek, Anna Partyka, Daria Wilczynska, Karolina Pytka, Gniewomir Latacz, Katarzyna Przejczowska-Pomierny, Elzbieta Wyska, Anna Wesolowska, Maciej Pawlowski, Adrian Newman-Tancredi, Marcin Kolaczkowski
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Veronika Rucilova, Artur Swierczek, David Vanda, Petr Funk, Barbora Lemrova, Alicja Gawalska, Adam Bucki, Barbara Nowak, Monika Zadrozna, Krzysztof Pociecha, Miroslav Soural, Elzbieta Wyska, Maciej Pawlowski, Grazyna Chlon-Rzepa, Pawel Zajdel
Summary: In this study, a series of potential anti-inflammatory compounds for the treatment of autoimmune diseases were rapidly synthesized using a new synthetic approach. Hit compounds with inhibitory activity against phosphodiesterase 4 were identified, showing beneficial effects in various animal models of inflammatory and autoimmune diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Jankowska, Grzegorz Satala, Gniewomir Latacz, Anna Partyka, Annamaria Lubelska, Krzysztof Pociecha, Artur Swierczek, Natalia Wilczynska, Barbara Mordyl, Andrzej J. Bojarski, Elzbieta Wyska, Grazyna Chlon-Rzepa
Summary: The study aimed to develop novel aminoalkanamides with serotonin receptor affinity and phosphodiesterase inhibitory activity to combat neurodegeneration and symptoms of Alzheimer's disease. Compound 15 showed neuroprotective, procognitive, and antidepressant properties, with suitable ADME characteristics. This study revealed a new class of compounds that may be useful in the search for an effective drug in the alleviation of neurodegeneration and symptoms of Alzheimer's disease.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Mateusz Pierog, Katarzyna Soca, Urszula Doboszewska, Elzbieta Wyska, Leszek Guz, Aleksandra Szopa, Anna Serefko, Ewa Poleszak, Piotr Wlaz
Summary: This study investigated the behavioral effects of five classic antiseizure drugs in adult zebrafish, and found that VPA, DZP, and PB significantly increased seizure latency, while PHT and CBZ showed anticonvulsant-like effects. DZP decreased locomotor activity, and PHT and PB had strong anxiolytic-like effects. The study confirms the advantages of using adult zebrafish with mature CNS for neuropharmacological research on antiseizure drugs.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Agnieszka Jankowska, Grzegorz Satala, Artur Swierczek, Krzysztof Pociecha, Anna Partyka, Magdalena Jastrzebska-Wiesek, Monika Gluch-Lutwin, Andrzej J. Bojarski, Elzbieta Wyska, Grazyna Chlon-Rzepa
Summary: This study aimed to search for new procognitive and antidepressant drugs among amide derivatives of aminoalkanoic acids with 5-HT1A receptor antagonistic properties. A selected 5-HT1A receptor antagonist 20 showed procognitive and antidepressant activity in vivo, indicating its potential as a psychotropic drug.
FUTURE MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Malgorzata Zygmunt, Marietta Slusarczyk, Agnieszka Jankowska, Artur Swierczek, Adrian Bryla, Szczepan Mogilski, Grzegorz Kazek, Jacek Sapa, Elzbieta Wyska, Grazyna Chlon-Rzepa
Summary: The evaluated compounds in this study demonstrate analgesic and anti-inflammatory activities, with compound 36 showing additional antiarthritic effects and favorable pharmacokinetic properties in rats. These compounds represent a new class of derivatives that involve TRPA1 antagonism and PDE4/7 inhibition.
PHARMACOLOGICAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Urszula Doboszewska, Katarzyna Socala, Mateusz Pierog, Dorota Nieoczym, Jan Sawicki, Malgorzata Szafarz, Kinga Gawel, Anna Rafalo-Ulinska, Adam Sajnog, Elzbieta Wyska, Camila V. Esguerra, Bernadeta Szewczyk, Marzena Mackowiak, Danuta Baralkiewicz, Katarzyna Mlyniec, Gabriel Nowak, Ireneusz Sowa, Piotr Wlaz
Summary: This study found that TC-G 1008 exacerbated seizures and epileptogenesis, but its mechanism may not be solely through activating the GPR39 receptor. Therefore, activating GPR39 may not be a viable therapeutic strategy for treating epilepsy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Meeting Abstract
Respiratory System
Katarzyna Wojcik-Pszczola, Bogdan Jakiela, Hanna Plutecka, Agnieszka Jankowska, Marietta Slusarczyk, Grazyna Chlon-Rzepa, Krzysztof Pociecha, Artur Swierczek, Elzbieta Wyska, Paulina Koczurkiewicz-Adamczyk, Elzbieta Pekala, Reinoud Gosens
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Monika Kubacka, Anna Rapacz, Kinga Salat, Barbara Filipek, Agnieszka Cios, Krzysztof Pociecha, Elzbieta Wyska, Urszula Hubicka, Barbara Zuromska-Witek, Anna Kwiecien, Henryk Marona, Anna M. Waszkielewicz
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)