Article
Public, Environmental & Occupational Health
Adarsh Varma, Sheri Trudeau, Yueren Zhou, Syed-Mohammed Jafri, Richard Krajenta, Lois Lamerato, Kimberly Brown, Veronica Luzzi, Mei Lu, Stuart C. Gordon
Summary: Research shows that African Americans have significantly lower ALT levels than non-African Americans, indicating potential differences in normal ranges among different racial groups. Establishing race-specific normal ranges for ALT could contribute to improved screening and care for African American patients.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2021)
Article
Biochemistry & Molecular Biology
Cristina Duarte Silva, Catia Ramalhete, Gabriella Spengler, Silva Mulhovo, Joseph Molnar, Maria-Jose U. Ferreira
Summary: Compounds extracted from Momordica balsamina have shown potential as multidrug resistance (MDR) reversers and have synergistic effects with doxorubicin.
Article
Neurosciences
Erica S. Modeste, Lingyan Ping, Caroline M. Watson, Duc M. Duong, Eric B. Dammer, Erik C. B. Johnson, Blaine R. Roberts, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
Summary: Despite being at higher risk for Alzheimer's disease, African Americans have been underrepresented in AD research. This study used proteomic profiling to identify common and divergent AD biomarkers in the cerebrospinal fluid of African Americans and Caucasians.
MOLECULAR NEURODEGENERATION
(2023)
Article
Endocrinology & Metabolism
Rebecca Baqiyyah N. Conway, Staci Sudenga, Donald McClain, William J. Blot
Summary: The study from the Southern Community Cohort found a significant difference in the association between diabetes and liver cancer risk among African Americans and White/European Americans. Diabetes has a more significant impact on liver cancer risk among White/European Americans compared to African Americans.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Health Care Sciences & Services
Kandauda A. S. Wickrama, Penny A. Ralston, Jasminka Z. Ilich
Summary: Perceived lower life satisfaction is positively associated with inflammation levels mediated by body adiposity, with a stronger association in women. These findings contribute to understanding mediation/moderation processes and suggest interventions should focus on African Americans, particularly women.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Wala Al Balwi, Maha Al Turki, Ziad A. Memish, Hana M. A. Fakhoury, Mohammed Al Balwi, Ali H. Hajeer
Summary: This study investigated the impact of age and BMI on the risk of death in COVID-19 patients. The results showed that age, hypertension, and cardiac disease were predictors of death, while increased BMI seemed to have a protective effect in older age groups. Therefore, a new score combining age and BMI was suggested, which showed a higher predictive value for death than age alone.
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH
(2022)
Article
Multidisciplinary Sciences
Mohammad Y. Anwar, Laura M. Raffield, Leslie A. Lange, Adolfo Correa, Kira C. Taylor
Summary: The study suggests that genetic factors influence adiposity patterns in African Americans, with genetic risk scores being associated with different adiposity measures. Increases in body fat percentage are strongly linked to subcutaneous adiposity rather than visceral adiposity.
Article
Engineering, Environmental
Lu-Dan Zhang, Xiang Liu, Ming-Yue Wei, Ze-Jun Guo, Zhi-Zhu Zhao, Chang-Hao Gao, Jing Li, Jian-Xin Xu, Zhi-Jun Shen, Hai-Lei Zheng
Summary: The study found that ammonium is more effective in detoxifying Cd in plants, mainly due to its regulation of Cd influx and accumulation, increased retention of Cd in cell walls, and up-regulation of SnExp expression.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Oncology
Geffen Kleinstern, J. Brice Weinberg, Sameer A. Parikh, Esteban Braggio, Sara J. Achenbach, Dennis P. Robinson, Aaron D. Norman, Kari G. Rabe, Nicholas J. Boddicker, Celine M. Vachon, Connie E. Lesnick, Timothy G. Call, Danielle M. Brander, Laura Z. Rassenti, Thomas J. Kipps, Janet E. Olson, James R. Cerhan, Neil E. Kay, Richard R. Furman, Curtis A. Hanson, Tait D. Shanafelt, Susan L. Slager
Summary: This study found significant associations between 41 CLL susceptibility variants and CLL-PRS with MBL risk, while little evidence of any association between MBL risk and environmental factors was observed. The CLL-PRS showed significant associations with EA-CLL risk and AA-CLL risk, indicating the need for further research in this population.
Article
Gastroenterology & Hepatology
Sanjaya K. Satapathy, Hemnishil K. Marella, Rajiv P. Heda, Surosree Ganguli, Yala Kirthi Reddy, Pradeep S. B. Podila, Ian Clark, Benedict Maliakkal
Summary: This study found that there are clinical, biochemical, and histological differences between African-Americans and Caucasians in NAFLD. Caucasians have a higher rate of NASH and are more likely to develop advanced fibrosis compared to African-Americans.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Evolutionary Biology
Herbert Kasozi, Remington J. Moll, Robert M. Kityo, Robert A. Montgomery
Summary: By studying a community of 22 sympatric mammal species in Murchison Falls National Park, Uganda, we found that phylogeny is a stronger predictor of species activity levels than body mass. Our findings provide empirical evidence for the phylogenetic structuring of mammal activity in diverse communities, and suggest the importance of evolutionary relationships in predicting species traits in diverse animal communities.
BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Stephanie A. Newman, Yijun Pan, Jennifer L. Short, Joseph A. Nicolazzo
Summary: These studies demonstrate that iron negatively regulates P-gp expression at the BBB, potentially impacting CNS drug delivery and brain beta-amyloid clearance.
PHARMACEUTICAL RESEARCH
(2021)
Article
Virology
Wei Zhao, Peng Zhang, Shuang Bai, Min Lv, Jian Wang, Weixin Chen, Qingzhong Yu, Jiang Wu
Summary: The study found that using a Newcastle disease virus as a priming immunization followed by boosting with a adenovirus type 5 vaccine in mice led to stronger Ebola virus GP-specific antibody and T-cell responses compared to receiving the same vaccine twice. This indicates the potential of the NDV vector in enhancing Ebola-specific immunity in human vaccine use.
ARCHIVES OF VIROLOGY
(2021)
Article
Pharmacology & Pharmacy
Firzana Firfirey, Alison September, Delva Shamley
Summary: This study found a significant association between the ABCB1 gene and shoulder pain and disability, and identified specific genetic intervals within ABCB1 and OPRM1 related to chronic shoulder pain and disability. Evidence suggests that potential gene-gene interactions between ABCB1 and OPRM1 may contribute to chronic shoulder pain and disability in this cohort.
Article
Public, Environmental & Occupational Health
Margrethe F. Horlyck-Romanovsky, Maria Farag, Sonali Bhat, Lakshay Khosla, Timothy S. McNeel, Faustine Williams
Summary: This study examines the differences in diabetes prevalence, anthropometric profiles, and odds of diabetes between Afro-Caribbeans and African Americans in New York City, revealing that while there are differences in body measurements, there are no differences in the likelihood of having diabetes between the two groups.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Article
Environmental Sciences
Svetlana Fa, Trine Vilsboll Larsen, Katrine Bilde, Tina F. Daugaard, Emil H. Ernst, Karin Lykke-Hartmann, Rasmus H. Olesen, Linn S. Mamsen, Erik Ernst, Agnete Larsen, Anders L. Nielsen
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Anne Skottrup Morkholt, Kenneth Kastaniegaard, Michael Sloth Trabjerg, Gopana Gopalasingam, Wanda Niganze, Agnete Larsen, Allan Stensballe, Soren Nielsen, John Dirk Nieland
SCIENTIFIC REPORTS
(2018)
Article
Integrative & Complementary Medicine
Tabia Volqvartz, Anna Louise Vestergaard, Sissel Kramer Aagaard, Mette Findal Andreasen, Iana Lesnikova, Niels Uldbjerg, Agnete Larsen, Pinar Bor
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Multidisciplinary Sciences
Jordi Guiu, Edouard Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jorgensen, Signe Perlman, Lene Lundvall, Linn Salto Mamsen, Agnete Larsen, Rasmus H. Olesen, Claus Yding Andersen, Lea Langhoff Thuesen, Kristine Juul Hare, Tune H. Pers, Konstantin Khodosevich, Benjamin D. Simons, Kim B. Jensen
Article
Multidisciplinary Sciences
Trine Maxel, Kamille Smidt, Charlotte C. Petersen, Bent Honore, Anne K. Christensen, Per B. Jeppesen, Birgitte Brock, Jorgen Rungby, Johan Palmfeldt, Agnete Larsen
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Henrik Thyge Corfitsen, Betina Krantz, Agnete Larsen, Antonio Drago
ACTA NEUROPSYCHIATRICA
(2020)
Article
Obstetrics & Gynecology
Katrine Bilde, Rasmus H. Olesen, Emil H. Ernst, Linn S. Mamsen, Mahboobeh Amoushahi, Karin Lykke-Hartmann, Erik Ernst, Agnete Larsen
HUMAN REPRODUCTION
(2019)
Article
Pharmacology & Pharmacy
Tabia Volqvartz, Anna Louise Vestergaard, Sissel K. Aagaard, Mette F. Andreasen, Iana Lesnikova, Niels Uldbjerg, Agnete Larsen, Pinar Bor
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2020)
Review
Obstetrics & Gynecology
Nicolai B. Jensen, Signe D. Justesen, Agnete Larsen, Erik Ernst, Lars H. Pedersen
Summary: Immunosuppressant drug MTX shows transient spermatotoxic and genotoxic potentials in human and animal studies, affecting sperm quality parameters but returning to reference values within a few months. Data on GCV and MMF are limited and inconclusive, hence their spermatotoxic and genotoxic potentials cannot be ruled out.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Pharmacology & Pharmacy
Mette Ostergaard Thunbo, Julie Hauer Vendelbo, Tabia Volqvartz, Daniel R. Witte, Agnete Larsen, Lars Henning Pedersen
Summary: The study evaluated the risk of congenital malformations in polymorbid pregnancies exposed to first-trimester polypharmacy, and found that there is an increased risk of malformations in such cases. It is recommended to enhance pharmacovigilance to ensure safe drug use in early pregnancy.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Signe Justesen, Katrine Bilde, Rasmus H. Olesen, Lars H. Pedersen, Erik Ernst, Agnete Larsen
Summary: Obesity increases the risk of complications in pregnant women and has long-term adverse effects on the offspring. The expression of placental transporter proteins in early pregnancy can be influenced by maternal obesity. However, the expression of ABCG2, another transporter protein, is not affected. Further studies are needed to understand the regulation of placental transport proteins by maternal factors and their consequences for placental-fetal interaction.
SCIENTIFIC REPORTS
(2023)