期刊
ONCOIMMUNOLOGY
卷 7, 期 12, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2018.1499388
关键词
MDR1; Th1.17; chemo-resistance; drug efflux; anti-tumor immunity; autoimmunity; immune regulation; inhibitors; combination therapy
资金
- Breast Cancer Research Fundation (BCRF)
- Puy de Dome comity of the Ligue Contre le Cancer
- SIRIC project (LyriCAN) [INCa-DGOS-INSERM_12563]
- LABEX DEVweCAN of the University of Lyon within the program Investissements d'Avenir [ANR-10-LABX-0061]
- Ligue Nationale contre le Cancer
- FP7 European TumAdoR project [602200]
MDR1 is an ATP-dependent transmembrane transporter primarily studied for its role in the detoxification of tissues and for its implication in resistance of tumor cells to chemotherapy treatment. Several studies also report on its expression on immune cells where it plays a protective role from xenobiotics and toxins. This review provides an overview of what is known on MDR1 expression in immune cells in human, and its implications in different pathologies and their treatment options.
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