Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health

Prevention of tuberculosis in macaques after intravenous BCG immunization

(2020) Patricia A. Darrah et al.   NATURE

Combo of two HIV vaccines fails its big test

(2020) Jon Cohen   SCIENCE

Engineering Immune Tolerance with Biomaterials

(2019) Joshua M. Gammon et al.   Advanced Healthcare Materials

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

(2019) Jessica Marcandalli et al.   CELL

Augmenting the synergies of chemotherapy and immunotherapy through drug delivery

(2019) Jihoon Kim et al.   Acta Biomaterialia

Tuberculosis Vaccine Development: Progress in Clinical Evaluation

(2019) Suraj B. Sable et al.   CLINICAL MICROBIOLOGY REVIEWS

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

(2019) Kevin O. Saunders et al.   SCIENCE

Chitosan-based particulate systems for the delivery of mucosal vaccines against infectious diseases

(2018) Bijay Singh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8 + T cell responses

(2018) Youhui Si et al.   JOURNAL OF CONTROLLED RELEASE

Loading dendritic cells with gold nanoparticles (GNPs) bearing HIV-peptides and mannosides enhance HIV-specific T cell responses

(2018) Núria Climent et al.   Nanomedicine-Nanotechnology Biology and Medicine

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

(2018) Elisa Nemes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

(2018) Shanshan Hu et al.   Frontiers in Immunology

Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis

(2018) Olivier Van Der Meeren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design

(2018) Joel Finney et al.   Retrovirology

Nanoscale Peptide Self-assemblies Boost BCG-primed Cellular Immunity Against Mycobacterium tuberculosis

(2018) Charles B. Chesson et al.   Scientific Reports

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

(2018) Sheng Hong et al.   IMMUNITY

Interrogation of Antigen Display on Individual Vaccine Nanoparticles for Achieving Neutralizing Antibody Responses against Hepatitis C Virus

(2018) Joseph D. Bazzill et al.   NANO LETTERS

A malaria vaccine adjuvant based on recombinant antigen binding to liposomes

(2018) Wei-Chiao Huang et al.   Nature Nanotechnology

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

(2018) Talar Tokatlian et al.   SCIENCE

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

(2018) Talar Tokatlian et al.   Scientific Reports

Nanoparticle Vaccines Against Infectious Diseases

(2018) Rashmirekha Pati et al.   Frontiers in Immunology

Combination of RTS,S and Pfs25-IMX313 Induces a Functional Antibody Response Against Malaria Infection and Transmission in Mice

(2018) Florian Brod et al.   Frontiers in Immunology

The Development of Whole Sporozoite Vaccines for Plasmodium falciparum Malaria

(2018) Leslie S. Itsara et al.   Frontiers in Immunology

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

(2017) Paola Martinez-Murillo et al.   IMMUNITY

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Host controls of HIV broadly neutralizing antibody development

(2017) Garnett Kelsoe et al.   IMMUNOLOGICAL REVIEWS

Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies

(2017) Persephone Borrow et al.   IMMUNOLOGICAL REVIEWS

Co-utilization of a TLR5 agonist and nano-formulation of HIV-1 vaccine candidate leads to increased vaccine immunogenicity and decreased immunogenic dose: A preliminary study

(2017) Hajar Rostami et al.   IMMUNOLOGY LETTERS

Self-encapsulating Poly(lactic-co-glycolic acid) (PLGA) Microspheres for Intranasal Vaccine Delivery

(2017) Brittany A. Bailey et al.   MOLECULAR PHARMACEUTICS

V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144

(2017) Lautaro G. Perez et al.   PLoS One

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

(2017) Dmitri Kazmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Major findings and recent advances in virus–like particle (VLP)-based vaccines

(2017) Mona O. Mohsen et al.   SEMINARS IN IMMUNOLOGY

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

(2017) Todd Bradley et al.   Nature Communications

A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers

(2017) Yaoying Wu et al.   ACS Biomaterials-Science & Engineering

What Have We Learnt about BCG Vaccination in the Last 20 Years?

(2017) Hazel M. Dockrell et al.   Frontiers in Immunology

A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers

(2017) Yaoying Wu et al.   ACS Biomaterials Science & Engineering

HIV transmitted/founder vaccines elicit autologous tier 2 neutralizing antibodies for the CD4 binding site

(2017) Nathanael P. McCurley et al.   PLoS One

Switching the Immunogenicity of Peptide Assemblies Using Surface Properties

(2016) Yi Wen et al.   ACS Nano

Thermal stability of self-assembled peptide vaccine materials

(2016) Tao Sun et al.   Acta Biomaterialia

Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

(2016) Qi Yang et al.   ANALYTICAL CHEMISTRY

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunopathogenesis of tuberculosis and novel mechanisms of vaccine activity

(2016) Lewis K. Schrager et al.   TUBERCULOSIS

A first-in-human phase 1 trial to evaluate the safety and immunogenicity of the candidate tuberculosis vaccine MVA85A-IMX313, administered to BCG-vaccinated adults

(2016) Alice Minhinnick et al.   VACCINE

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

(2016) Christian Lienhardt et al.   PLOS MEDICINE

Flexible Macromolecule versus Rigid Particle Retention in the Injected Skin and Accumulation in Draining Lymph Nodes Are Differentially Influenced by Hydrodynamic Size

(2016) Nathan Andrew Rohner et al.   ACS Biomaterials-Science & Engineering

Modular Peptide Amphiphile Micelles Improving an Antibody-Mediated Immune Response to Group A Streptococcus

(2016) John C. Barrett et al.   ACS Biomaterials-Science & Engineering

Flexible Macromolecule versus Rigid Particle Retention in the Injected Skin and Accumulation in Draining Lymph Nodes Are Differentially Influenced by Hydrodynamic Size

(2016) Nathan Andrew Rohner et al.   ACS Biomaterials Science & Engineering

Modular Peptide Amphiphile Micelles Improving an Antibody-Mediated Immune Response to Group A Streptococcus

(2016) John C. Barrett et al.   ACS Biomaterials Science & Engineering

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Multivalent Antigens for Promoting B and T Cell Activation

(2015) Nitasha R. Bennett et al.   ACS Chemical Biology

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

(2015) Masaru Kanekiyo et al.   CELL

Synthetic Nanoparticles for Vaccines and Immunotherapy

(2015) Darrell J. Irvine et al.   CHEMICAL REVIEWS

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy

(2015) Jardin Leleux et al.   JOURNAL OF CONTROLLED RELEASE

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Ferritin family proteins and their use in bionanotechnology

(2015) Didi He et al.   New Biotechnology

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

(2015) Kwinten Sliepen et al.   Retrovirology

Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies

(2015) W. B. Williams et al.   SCIENCE

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

(2015) D. H. Barouch et al.   SCIENCE

Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25 attached gold nanoparticles

(2015) Rajesh Kumar et al.   VACCINE

Designing malaria vaccines to circumvent antigen variability

(2015) Amed Ouattara et al.   VACCINE

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

(2015) Sampa Santra et al.   PLoS Pathogens

Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination

(2014) Sharmila Pejawar-Gaddy et al.   BIOCONJUGATE CHEMISTRY

Vaccines Against Malaria

(2014) A. Ouattara et al.   CLINICAL INFECTIOUS DISEASES

Gradated assembly of multiple proteins into supramolecular nanomaterials

(2014) Gregory A. Hudalla et al.   NATURE MATERIALS

Enhanced Immune Response and Protective Effects of Nano-chitosan-based DNA Vaccine Encoding T Cell Epitopes of Esat-6 and FL against Mycobacterium Tuberculosis Infection

(2014) Ganzhu Feng et al.   PLoS One

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

(2014) Petr O. Ilyinskii et al.   VACCINE

Titrating T-Cell Epitopes within Self-Assembled Vaccines Optimizes CD4+ Helper T Cell and Antibody Outputs

(2014) Rebecca R. Pompano et al.   Advanced Healthcare Materials

Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites

(2014)   PLOS MEDICINE

Why HIV Virions Have Low Numbers of Envelope Spikes: Implications for Vaccine Development

(2014) John Schiller et al.   PLoS Pathogens

Morphologically Virus-Like Fullerenol Nanoparticles Act as the Dual-Functional Nanoadjuvant for HIV-1 Vaccine

(2013) Ligeng Xu et al.   ADVANCED MATERIALS

Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

(2013) Peter Hraber et al.   AIDS

The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation

(2013) Jianjun Chen et al.   BIOMATERIALS

Nanoparticle diffusion in respiratory mucus from humans without lung disease

(2013) Benjamin S. Schuster et al.   BIOMATERIALS

HIV-1 neutralizing antibodies: understanding nature's pathways

(2013) John R. Mascola et al.   IMMUNOLOGICAL REVIEWS

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

Polymer multilayer tattooing for enhanced DNA vaccination

(2013) Peter C. DeMuth et al.   NATURE MATERIALS

The Immunogenicity of Polyethylene Glycol: Facts and Fiction

(2013) Huub Schellekens et al.   PHARMACEUTICAL RESEARCH

Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice

(2013) Iraklis C. Kourtis et al.   PLoS One

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

(2013) G. D. Tomaras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Antigenic peptide nanofibers elicit adjuvant-free CD8+ T cell responses

(2013) Charles B. Chesson et al.   VACCINE

Nanoparticle vaccines

(2013) Liang Zhao et al.   VACCINE

Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1

(2013) Sheetij Dutta et al.   PLoS Pathogens

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Vaccine delivery using nanoparticles

(2013) Anthony E. Gregory et al.   Frontiers in Cellular and Infection Microbiology

Modulating Adaptive Immune Responses to Peptide Self-Assemblies

(2012) Jai S. Rudra et al.   ACS Nano

Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo

(2012) Matthew Black et al.   ADVANCED MATERIALS

Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype

(2012) Stacey L. Demento et al.   BIOMATERIALS

Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope

(2012) Jai S. Rudra et al.   BIOMATERIALS

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials

(2012) D. C. Montefiori et al.   JOURNAL OF INFECTIOUS DISEASES

Immunization of Macaques With Soluble HIV Type 1 and Influenza Virus Envelope Glycoproteins Results in a Similarly Rapid Contraction of Peripheral B-Cell Responses After Boosting

(2012) Christopher Sundling, Paola Martinez, Martina Soldemo, Mats Spångberg, Karin Lövgren Bengtsson, Linda Stertman, Mattias N. E. Forsell et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family

(2012) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Construction and Characterization of Virus-Like Particles: A Review

(2012) Andris Zeltins   MOLECULAR BIOTECHNOLOGY

Nanoparticle-based adjuvant for enhanced protective efficacy of DNA vaccine Ag85A-ESAT-6-IL-21 against Mycobacterium tuberculosis infection

(2012) Fangliu Yu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fusion of the Mycobacterium tuberculosis Antigen 85A to an Oligomerization Domain Enhances Its Immunogenicity in Both Mice and Non-Human Primates

(2012) Alexandra J. Spencer et al.   PLoS One

Protective Antibody and CD8+ T-Cell Responses to the Plasmodium falciparum Circumsporozoite Protein Induced by a Nanoparticle Vaccine

(2012) Stephen A. Kaba et al.   PLoS One

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Approaches to Immunotherapy

(2012) M. A. Swartz et al.   Science Translational Medicine

Targeting the lymphatics using dendritic polymers (dendrimers)

(2011) Lisa M. Kaminskas et al.   ADVANCED DRUG DELIVERY REVIEWS

PEGylated cationic liposomes robustly augment vaccine-induced immune responses: Role of lymphatic trafficking and biodistribution

(2011) Yan Zhuang et al.   JOURNAL OF CONTROLLED RELEASE

Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected

(2011) E. T. Crooks et al.   JOURNAL OF VIROLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

(2011) D. R. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

(2011) Dmitri Smirnov et al.   VACCINE

Immunogenicity of novel nanoparticle-coated MSP-1 C-terminus malaria DNA vaccine using different routes of administration

(2011) Mahamoud Sama Cherif et al.   VACCINE

Polyacrylate Dendrimer Nanoparticles: A Self-Adjuvanting Vaccine Delivery System

(2010) Mariusz Skwarczynski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

(2010) Deepa Mohanan et al.   JOURNAL OF CONTROLLED RELEASE

The Achilles heel of BCG

(2010) Ian M. Orme   TUBERCULOSIS

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

(2010) Sachiko Hirosue et al.   VACCINE

Micro- and macrorheology of mucus

(2009) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules

(2009) Siow-Feng Chong et al.   BIOMATERIALS

A Nonadjuvanted Polypeptide Nanoparticle Vaccine Confers Long-Lasting Protection against Rodent Malaria

(2009) S. A. Kaba et al.   JOURNAL OF IMMUNOLOGY

T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces

(2009) B. T. Korber et al.   JOURNAL OF VIROLOGY

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

(2009) S. K. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A self-assembling peptide acting as an immune adjuvant

(2009) J. S. Rudra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers

(2009) Ann J. Hessell et al.   PLoS Pathogens

Nanotechnology in vaccine delivery

(2008) Laura J. Peek et al.   ADVANCED DRUG DELIVERY REVIEWS

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

The Oligomerization Domain of C4-Binding Protein (C4bp) Acts as an Adjuvant, and the Fusion Protein Comprised of the 19-Kilodalton Merozoite Surface Protein 1 Fused with the Murine C4bp Domain Protects Mice against Malaria

(2008) S. A. Ogun et al.   INFECTION AND IMMUNITY

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

(2008) N. W. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA