Article
Immunology
Nikolas Duszenko, Roos van Schuijlenburg, Severine Chevalley-Maurel, Danny M. van Willigen, Laura de Bes-Roeleveld, Stefanie van der Wees, Chanel Naar, Els Baalbergen, Graham Heieis, Anton Bunschoten, Aldrik H. Velders, Blandine Franke-Fayard, Fijs W. B. van Leeuwen, Meta Roestenberg
Summary: By using supramolecular chemistry to chemically modify the parasite surface with a TLR7 agonist-based adjuvant, the immunogenicity of SPZ vaccines was enhanced, showing promise for improving malaria vaccine design.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Kjersti Flatmark, Annette Torgunrud, Karianne G. Fleten, Ben Davidson, Hedvig Juul, Nadia Mensali, Christin Lund-Andersen, Else Marit Inderberg
Summary: Pseudomyxoma peritonei (PMP) is a rare abdominal cancer without effective treatments in non-resectable cases, but GNAS mutations are common, providing a target for therapeutic cancer vaccines. Tumor samples from PMP patients showed a pre-existing immunity towards mutated Gs alpha, but immune checkpoint molecules may inhibit antitumor T cells. This suggests that peptide vaccination with Gs alpha peptides in combination with immune checkpoint inhibition could be a potential treatment for PMP and other GNAS mutated cancers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Magdalena K. Scheck, Lisa Lehmann, Magdalena Zaucha, Paul Schwarzlmueller, Kristina Huber, Michael Pritsch, Giovanna Barba-Spaeth, Oliver Thorn-Seshold, Anne B. Krug, Stefan Endres, Simon Rothenfusser, Julia Thorn-Seshold
Summary: Better diagnostic and analytical methods are urgently needed for vaccine research and infection control in virology. This study presents a Fluorescence Reduction Neutralisation Test (FluoRNT) for yellow fever virus, which accurately measures neutralising antibody titres in human serum samples within 24 hours.
Article
Biochemistry & Molecular Biology
Fan-Yue Meng, Fan Gao, Si-Yue Jia, Xiang-Hong Wu, Jing-Xin Li, Xi-Ling Guo, Jia-Lu Zhang, Bo-Pei Cui, Zhi-Ming Wu, Ming-Wei Wei, Zhi-Long Ma, Hai-Lin Peng, Hong-Xing Pan, Lin Fan, Jing Zhang, Jiu-Qin Wan, Zhong-Kui Zhu, Xue-Wen Wang, Feng-Cai Zhu
Summary: The vaccine was tested in two trials in China, showing that after three doses, it is safe and induces significant immune responses in healthy individuals aged 18 and older.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Immunology
Silvia Scoccianti, Camilla Delli Paoli, Maria Infantino, Lisa Paoletti, Saverio Caini, Fiammetta Meacci, Serenella Russo, Marco Esposito, Simona Fondelli, Barbara Grilli Leonulli, Valentina Grossi, Raffaella Barca, Paolo Alpi, Federica Furlan, Marco Perna, Maria Simona Pino, Francesca Martella, Mariangela Manfredi, Marco Stefanacci, Andrea Bassetti, Patrizia Casprini, Luisa Fioretto
Summary: This study investigated the immune response of patients treated with radiotherapy after receiving SARS-CoV-2 vaccines. The results showed that most patients had a low immune response after the second dose of the vaccine, but the immune response significantly improved after the third dose, providing effective protection against SARS-CoV-2. Therefore, patients undergoing radiotherapy can also achieve good vaccine protection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Roos S. G. Sablerolles, Wim J. R. Rietdijk, Abraham Goorhuis, Douwe F. Postma, Leo G. Visser, Daryl Geers, Katharina S. Schmitz, Hannah M. Garcia Garrido, Marion P. G. Koopmans, Virgil A. S. H. Dalm, Neeltje A. Kootstra, Anke L. W. Huckriede, Melvin Lafeber, Debbie van Baarle, Corine H. GeurtsvanKessel, Rory D. de Vries, P. Hugo M. van der Kuy
Summary: This study investigated the immunogenicity and reactogenicity of a homologous or heterologous booster in healthcare workers who had received a single-shot Ad26.COV2.S vaccine. The results showed that booster vaccinations increased the levels of S-specific binding antibodies, neutralizing antibodies, and T-cell responses compared to a single Ad26.COV2.S vaccination. Boosters containing mRNA-based vaccines induced significantly higher levels of binding antibodies than homologous boosters. The mRNA-1273 booster was the most immunogenic but had higher reactogenicity compared to the BNT162b2 and Ad26.COV2.S boosters. Local and systemic reactions were generally mild to moderate in the first 2 days after booster administration.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Arabella S. Stuart, Robert H. Shaw, Xinxue Liu, Melanie Greenland, Parvinder K. Aley, Nick J. Andrews, J. C. Cameron, Sue Charlton, Elizabeth A. Clutterbuck, Andrea M. Collins, Tom Darton, Tanya Dinesh, Christopher J. A. Duncan, Anna England, Saul N. Faust, Daniela M. Ferreira, Adam Finn, Anna L. Goodman, Christopher A. Green, Bassam Hallis, Paul T. Heath, Helen Hill, Bryn M. Horsington, Teresa Lambe, Rajeka Lazarus, Vincenzo Libri, Patrick J. Lillie, Yama F. Mujadidi, Ruth Payne, Emma L. Plested, Samuel Provstgaard-Morys, Maheshi N. Ramasamy, Mary Ramsay, Robert C. Read, Hannah Robinson, Gavin R. Screaton, Nisha Singh, David P. J. Turner, Paul J. Turner, Iason Vichos, Rachel White, Jonathan S. Nguyen-Van-Tam, Matthew D. Snape
Summary: The study investigated the mixed use of different COVID-19 vaccines within the same schedule, showing that in certain conditions, heterologous vaccination can achieve similar immunogenicity to homologous vaccination, facilitating rapid global vaccine deployment.
Article
Materials Science, Multidisciplinary
Tiantian Xia, Xiaotong Cheng, Xianbao Sun, Gaolin Liang
Summary: In this work, an anthracene-peptide gelator with photochemically regulated gel-sol switches is reported. The gel-sol transition can be achieved through laser irradiation at different wavelengths, providing a controllable method to manipulate the gel properties.
ACS MATERIALS LETTERS
(2022)
Article
Multidisciplinary Sciences
Suad Hannawi, Linda Saifeldin, Alaa Abuquta, Ahmad Alamadi, Sally A. Mahmoud, Aala Hassan, Shuping Xu, Jian Li, Dongfang Liu, Adam Abdul Hakeem Baidoo, Dima Ibrahim, Mojtaba Alhaj, Yuanxin Chen, Qiang Zhou, Liangzhi Xie
Summary: The safety and immunogenicity of a protein-based tetravalent vaccine SCTV01E were evaluated and compared with a bivalent protein vaccine SCTV01C and a monovalent mRNA vaccine. The results showed that SCTV01E had superior neutralizing antibody levels and immune response compared to the other two vaccines.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Robert M. F. van der Put, Arnoud Spies, Bernard Metz, Daniel Some, Roger Scherrers, Roland Pieters, Maarten Danial
Summary: In this study, a FFF-MALS method was developed for the characterization of OMVs, and NIST-traceable particle-size standards and BSA were used for validation. The validation results showed excellent accuracy and reliability of the method. Furthermore, the validated method was used for the characterization of a purification process and different OMVs from bacterial origin. Lastly, functionalization of OMVs did not affect their structural integrity, as evaluated by the validated FFF-MALS method.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Shu Yazaki, Tatsuya Yoshida, Yuki Kojima, Shigehiro Yagishita, Hiroko Nakahama, Keiji Okinaka, Hiromichi Matsushita, Mika Shiotsuka, Osamu Kobayashi, Satoshi Iwata, Yoshitaka Narita, Akihiro Ohba, Masamichi Takahashi, Satoru Iwasa, Kenya Kobayashi, Yuichiro Ohe, Tomokazu Yoshida, Akinobu Hamada, Toshihiko Doi, Noboru Yamamoto
Summary: This study evaluated the serum SARS-CoV-2 antibody status in cancer patients and healthcare workers in Japan during the COVID-19 pandemic. The seroprevalence did not differ significantly between the two groups, but it was found that cancer comorbidity and treatment with chemotherapy and immune checkpoint inhibitors may impact the immune response to SARS-CoV-2.
Article
Chemistry, Multidisciplinary
Hiromi Miwa, Olivia Q. Antao, Kindra M. Kelly-Scumpia, Sevana Baghdasarian, Daniel P. Mayer, Lily Shang, Gina M. Sanchez, Maani M. Archang, Philip O. Scumpia, Jason S. Weinstein, Dino Di Carlo
Summary: Improving physical and chemical properties of vaccine platforms can enhance adjuvanticity, boost humoral immunity, and protect against pathogen invasion. The flexibility of this new adjuvant platform allows for the design of new vaccines to enhance innate and adaptive immune cell programming, generate, and tune high affinity antibodies, resulting in long-lasting immunity.
Article
Oncology
Ruhul H. Choudhury, Peter Symonds, Samantha J. Paston, Ian Daniels, Katherine W. Cook, Mohamed Gijon, Rachael L. Metheringham, Victoria A. Brentville, Lindy G. Durrant
Summary: This study demonstrates that PAD2 enzyme can citrullinate the nuclear antigen NPM at position 277, leading to CD4 T cell-mediated antitumor response. Stimulation with citrullinated NPM peptides as vaccines can induce antitumor immune responses and result in significant tumor therapy effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Megan E. Grund, Eliza Kramarska, Soo Jeon Choi, Dudley H. McNitt, Christopher P. Klimko, Nathaniel O. Rill, Jennifer L. Dankmeyer, Jennifer L. Shoe, Melissa Hunter, David P. Fetterer, Zander M. Hedrick, Ivan Velez, Sergei S. Biryukov, Christopher K. Cote, Rita Berisio, Slawomir Lukomski
Summary: This study examined the immune response to a vaccine formulated with antigens derived from the outer membrane protein Bucl8 in Burkholderia pseudomallei and found that synthetic loop peptides elicited a stronger and more consistent antibody response compared to recombinant protein antigens, resulting in a TH2-skewed response.
Article
Critical Care Medicine
Szu-Min Hsieh, Ming-Che Liu, Yen-Hsu Chen, Wen-Sen Lee, Shinn-Jang Hwang, Shu-Hsing Cheng, Wen-Chien Ko, Kao-Pin Hwang, Ning-Chi Wang, Yu-Lin Lee, Yi-Ling Lin, Shin-Ru Shih, Chung-Guei Huang, Chun-Che Liao, Jian-Jong Liang, Chih-Shin Chang, Charles Chen, Chia En Lien, I-Chen Tai, Tzou-Yien Lin
Summary: The phase 2 clinical trial of the MVC-COV1901 vaccine in Taiwan showed promising results in terms of safety and immunogenicity, supporting further phase 3 efficacy trials.
LANCET RESPIRATORY MEDICINE
(2021)