Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

(2018) Talar Tokatlian et al.   Scientific Reports

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

(2017) Paola Martinez-Murillo et al.   IMMUNITY

Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses

(2017) Shridhar Bale et al.   JOURNAL OF VIROLOGY

Structural and functional diversity of collectins and ficolins and their relationship to disease

(2017) Mark Howard et al.   Seminars in Immunopathology

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

(2017) Daniel W. Kulp et al.   Nature Communications

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

(2016) Jon M. Steichen et al.   IMMUNITY

A journey through the lectin pathway of complement-MBL and beyond

(2016) Peter Garred et al.   IMMUNOLOGICAL REVIEWS

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+T Cells in Blood

(2016) Jennifer M. Dan et al.   JOURNAL OF IMMUNOLOGY

Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique

(2016) Colin Havenar-Daughton et al.   JOURNAL OF IMMUNOLOGY

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

(2016) D. Sok et al.   SCIENCE

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

(2016) J. G. Jardine et al.   SCIENCE

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

(2016) Linling He et al.   Nature Communications

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells

(2016) Jidnyasa Ingale et al.   Cell Reports

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

(2015) Masaru Kanekiyo et al.   CELL

T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses

(2015) Dan Suan et al.   IMMUNITY

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

(2015) Kwinten Sliepen et al.   Retrovirology

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

(2015) Chung Park et al.   eLife

Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine

(2014) Paulo S Naud et al.   Human Vaccines & Immunotherapeutics

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Mannose-binding lectin and innate immunity

(2009) W. K. Eddie Ip et al.   IMMUNOLOGICAL REVIEWS

Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation

(2009) Tri Giang Phan et al.   NATURE IMMUNOLOGY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY