Article
Oncology
Kjersti Flatmark, Annette Torgunrud, Karianne G. Fleten, Ben Davidson, Hedvig Juul, Nadia Mensali, Christin Lund-Andersen, Else Marit Inderberg
Summary: Pseudomyxoma peritonei (PMP) is a rare abdominal cancer without effective treatments in non-resectable cases, but GNAS mutations are common, providing a target for therapeutic cancer vaccines. Tumor samples from PMP patients showed a pre-existing immunity towards mutated Gs alpha, but immune checkpoint molecules may inhibit antitumor T cells. This suggests that peptide vaccination with Gs alpha peptides in combination with immune checkpoint inhibition could be a potential treatment for PMP and other GNAS mutated cancers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Infectious Diseases
Yu Hwa Choi, Young Ae Kang, Kwang Joo Park, Jae Chol Choi, Kwan Goo Cho, Da Yeon Ko, Jun Ho Ahn, Boram Lee, Eunsol Ahn, Yun Ju Woo, Kwangsoo Jung, Nan Yul Kim, Valerie A. A. Reese, Sasha E. E. Larsen, Susan L. L. Baldwin, Steven G. G. Reed, Rhea N. N. Coler, Hyejon Lee, Sang-Nae Cho
Summary: This study evaluated the safety and immunogenicity of the ID93 + GLA-SE vaccine in healthy adults. The results showed that the vaccine induced specific cellular and humoral immune responses, with an acceptable safety profile.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Magdalena K. Scheck, Lisa Lehmann, Magdalena Zaucha, Paul Schwarzlmueller, Kristina Huber, Michael Pritsch, Giovanna Barba-Spaeth, Oliver Thorn-Seshold, Anne B. Krug, Stefan Endres, Simon Rothenfusser, Julia Thorn-Seshold
Summary: Better diagnostic and analytical methods are urgently needed for vaccine research and infection control in virology. This study presents a Fluorescence Reduction Neutralisation Test (FluoRNT) for yellow fever virus, which accurately measures neutralising antibody titres in human serum samples within 24 hours.
Article
Biochemistry & Molecular Biology
Fan-Yue Meng, Fan Gao, Si-Yue Jia, Xiang-Hong Wu, Jing-Xin Li, Xi-Ling Guo, Jia-Lu Zhang, Bo-Pei Cui, Zhi-Ming Wu, Ming-Wei Wei, Zhi-Long Ma, Hai-Lin Peng, Hong-Xing Pan, Lin Fan, Jing Zhang, Jiu-Qin Wan, Zhong-Kui Zhu, Xue-Wen Wang, Feng-Cai Zhu
Summary: The vaccine was tested in two trials in China, showing that after three doses, it is safe and induces significant immune responses in healthy individuals aged 18 and older.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Immunology
Silvia Scoccianti, Camilla Delli Paoli, Maria Infantino, Lisa Paoletti, Saverio Caini, Fiammetta Meacci, Serenella Russo, Marco Esposito, Simona Fondelli, Barbara Grilli Leonulli, Valentina Grossi, Raffaella Barca, Paolo Alpi, Federica Furlan, Marco Perna, Maria Simona Pino, Francesca Martella, Mariangela Manfredi, Marco Stefanacci, Andrea Bassetti, Patrizia Casprini, Luisa Fioretto
Summary: This study investigated the immune response of patients treated with radiotherapy after receiving SARS-CoV-2 vaccines. The results showed that most patients had a low immune response after the second dose of the vaccine, but the immune response significantly improved after the third dose, providing effective protection against SARS-CoV-2. Therefore, patients undergoing radiotherapy can also achieve good vaccine protection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Roos S. G. Sablerolles, Wim J. R. Rietdijk, Abraham Goorhuis, Douwe F. Postma, Leo G. Visser, Daryl Geers, Katharina S. Schmitz, Hannah M. Garcia Garrido, Marion P. G. Koopmans, Virgil A. S. H. Dalm, Neeltje A. Kootstra, Anke L. W. Huckriede, Melvin Lafeber, Debbie van Baarle, Corine H. GeurtsvanKessel, Rory D. de Vries, P. Hugo M. van der Kuy
Summary: This study investigated the immunogenicity and reactogenicity of a homologous or heterologous booster in healthcare workers who had received a single-shot Ad26.COV2.S vaccine. The results showed that booster vaccinations increased the levels of S-specific binding antibodies, neutralizing antibodies, and T-cell responses compared to a single Ad26.COV2.S vaccination. Boosters containing mRNA-based vaccines induced significantly higher levels of binding antibodies than homologous boosters. The mRNA-1273 booster was the most immunogenic but had higher reactogenicity compared to the BNT162b2 and Ad26.COV2.S boosters. Local and systemic reactions were generally mild to moderate in the first 2 days after booster administration.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Arabella S. Stuart, Robert H. Shaw, Xinxue Liu, Melanie Greenland, Parvinder K. Aley, Nick J. Andrews, J. C. Cameron, Sue Charlton, Elizabeth A. Clutterbuck, Andrea M. Collins, Tom Darton, Tanya Dinesh, Christopher J. A. Duncan, Anna England, Saul N. Faust, Daniela M. Ferreira, Adam Finn, Anna L. Goodman, Christopher A. Green, Bassam Hallis, Paul T. Heath, Helen Hill, Bryn M. Horsington, Teresa Lambe, Rajeka Lazarus, Vincenzo Libri, Patrick J. Lillie, Yama F. Mujadidi, Ruth Payne, Emma L. Plested, Samuel Provstgaard-Morys, Maheshi N. Ramasamy, Mary Ramsay, Robert C. Read, Hannah Robinson, Gavin R. Screaton, Nisha Singh, David P. J. Turner, Paul J. Turner, Iason Vichos, Rachel White, Jonathan S. Nguyen-Van-Tam, Matthew D. Snape
Summary: The study investigated the mixed use of different COVID-19 vaccines within the same schedule, showing that in certain conditions, heterologous vaccination can achieve similar immunogenicity to homologous vaccination, facilitating rapid global vaccine deployment.
Article
Infectious Diseases
Lei Yang, Feng Xiang, Dian Wang, Qiao Guo, Bing Deng, DePeng Jiang, Hong Ren
Summary: The immunogenicity and safety of COVID-19 vaccines were assessed in patients with a history of pulmonary tuberculosis. The inactivated vaccines were well tolerated but showed limited immunogenicity in this population.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Binda T. Andongma, Yazheng Huang, Fang Chen, Qing Tang, Min Yang, Shan-Ho Chou, Xinfeng Li, Jin He
Summary: Tuberculosis is a global health threat causing 1.5 million deaths annually. This study designed a multi-epitope vaccine against TB using an immuno-informatics approach. The predicted vaccine showed stability, safety, high antigenicity, and immunogenicity, indicating its potential as a global TB vaccine.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Suad Hannawi, Linda Saifeldin, Alaa Abuquta, Ahmad Alamadi, Sally A. Mahmoud, Aala Hassan, Shuping Xu, Jian Li, Dongfang Liu, Adam Abdul Hakeem Baidoo, Dima Ibrahim, Mojtaba Alhaj, Yuanxin Chen, Qiang Zhou, Liangzhi Xie
Summary: The safety and immunogenicity of a protein-based tetravalent vaccine SCTV01E were evaluated and compared with a bivalent protein vaccine SCTV01C and a monovalent mRNA vaccine. The results showed that SCTV01E had superior neutralizing antibody levels and immune response compared to the other two vaccines.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Robert M. F. van der Put, Arnoud Spies, Bernard Metz, Daniel Some, Roger Scherrers, Roland Pieters, Maarten Danial
Summary: In this study, a FFF-MALS method was developed for the characterization of OMVs, and NIST-traceable particle-size standards and BSA were used for validation. The validation results showed excellent accuracy and reliability of the method. Furthermore, the validated method was used for the characterization of a purification process and different OMVs from bacterial origin. Lastly, functionalization of OMVs did not affect their structural integrity, as evaluated by the validated FFF-MALS method.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Shu Yazaki, Tatsuya Yoshida, Yuki Kojima, Shigehiro Yagishita, Hiroko Nakahama, Keiji Okinaka, Hiromichi Matsushita, Mika Shiotsuka, Osamu Kobayashi, Satoshi Iwata, Yoshitaka Narita, Akihiro Ohba, Masamichi Takahashi, Satoru Iwasa, Kenya Kobayashi, Yuichiro Ohe, Tomokazu Yoshida, Akinobu Hamada, Toshihiko Doi, Noboru Yamamoto
Summary: This study evaluated the serum SARS-CoV-2 antibody status in cancer patients and healthcare workers in Japan during the COVID-19 pandemic. The seroprevalence did not differ significantly between the two groups, but it was found that cancer comorbidity and treatment with chemotherapy and immune checkpoint inhibitors may impact the immune response to SARS-CoV-2.
Article
Multidisciplinary Sciences
Margherita Coccia, Wivine Burny, Marie-Ange Demoitie, Paul Gillard, Robert A. van den Berg, Robbert van der Most
Summary: Transcriptional responses to adjuvanted vaccines can vary among populations due to individual differences in pathogen exposure and immunological memory. This study found that individuals with higher cell-mediated memory responses to TB had stronger transcriptional responses to the AS01-adjuvanted vaccine. However, after a second vaccination, the heterogeneity in responses decreased and became similar across all groups.
Article
Oncology
Ruhul H. Choudhury, Peter Symonds, Samantha J. Paston, Ian Daniels, Katherine W. Cook, Mohamed Gijon, Rachael L. Metheringham, Victoria A. Brentville, Lindy G. Durrant
Summary: This study demonstrates that PAD2 enzyme can citrullinate the nuclear antigen NPM at position 277, leading to CD4 T cell-mediated antitumor response. Stimulation with citrullinated NPM peptides as vaccines can induce antitumor immune responses and result in significant tumor therapy effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Megan E. Grund, Eliza Kramarska, Soo Jeon Choi, Dudley H. McNitt, Christopher P. Klimko, Nathaniel O. Rill, Jennifer L. Dankmeyer, Jennifer L. Shoe, Melissa Hunter, David P. Fetterer, Zander M. Hedrick, Ivan Velez, Sergei S. Biryukov, Christopher K. Cote, Rita Berisio, Slawomir Lukomski
Summary: This study examined the immune response to a vaccine formulated with antigens derived from the outer membrane protein Bucl8 in Burkholderia pseudomallei and found that synthetic loop peptides elicited a stronger and more consistent antibody response compared to recombinant protein antigens, resulting in a TH2-skewed response.
Article
Psychology, Clinical
Daniel Freeman, Sinead Lambe, Ly-Mee Yu, Jason Freeman, Andrew Chadwick, Cristian Vaccari, Felicity Waite, Laina Rosebrock, Ariane Petit, Samantha Vanderslott, Stephan Lewandowsky, Michael Larkin, Stefania Innocenti, Helen McShane, Andrew J. Pollard, Bao Sheng Loe
Summary: Blood-injection-injury fears contribute to approximately 10% of COVID-19 vaccine hesitancy in the UK adult population. Addressing these fears can improve the effectiveness of vaccination programs.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Immunology
Julia Bitencourt, Marco Polo Peralta-Alvarez, Morven Wilkie, Ashley Jacobs, Daniel Wright, Salem Salman Almujri, Shuailin Li, Stephanie A. Harris, Steven G. Smith, Sean C. Elias, Andrew D. White, Iman Satti, Sally S. Sharpe, Matthew K. O'Shea, Helen McShane, Rachel Tanner
Summary: Tuberculosis is a major health problem worldwide, and the currently-licensed BCG vaccine is not effective enough. Research has shown that the BCG vaccine can induce specific antibodies, which play a crucial role in cellular defense. These findings suggest that the humoral immune response should be further investigated in TB vaccine development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Kriti Verma, Wayne Croft, Hayden Pearce, Jianmin Zuo, Christine Stephens, Jane Nunnick, Francesca A. M. Kinsella, Ram Malladi, Paul Moss
Summary: Allogeneic stem cell transplantation is commonly used in hematopoietic malignancy treatment, but relapse is a major cause of treatment failure. This study analyzed the transcriptional and phenotypic profile of CD8+ T cells in the first month after transplantation and found that patients who experienced relapse had higher levels of T-cell activation and acquired a regulatory transcriptome. Additionally, high expression of the inhibitory receptor CD94/NKG2A and reduced expression of the activatory molecule CD96 were associated with increased relapse risk and reduced survival. These findings suggest CD94 and CD96 as potential targets for CD8-directed immunotherapy to improve patient outcomes.
Review
Oncology
Natalie To, Richard P. T. Evans, Hayden Pearce, Sivesh K. Kamarajah, Paul Moss, Ewen A. Griffiths
Summary: Oesophageal cancer is a global disease with high morbidity and mortality rates. Standard treatment options are limited, necessitating the exploration of new options. Immunotherapy, particularly checkpoint inhibitors, has shown great potential in the treatment of oesophageal cancer. This review discusses the mechanisms through which cancer evades the immune system and summarizes current and ongoing trials that utilize our immune system to combat the disease.
Letter
Pediatrics
Alexander C. Dowell, Georgina Ireland, Jianmin Zuo, Paul Moss, Shamez Ladhani
Article
Oncology
Hayden Pearce, Wayne Croft, Samantha M. Nicol, Sandra Margielewska-Davies, Richard Powell, Richard Cornall, Simon J. Davis, Francesca Marcon, Matthew R. Pugh, Eanna Fennell, Sarah Powell-Brett, Brinder S. Mahon, Rachel M. Brown, Gary Middleton, Keith Roberts, Paul Moss
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor clinical outlook, and a better understanding of the tumor immune microenvironment is needed. In this study, T cells were found to be the predominant immune cell subset within PDAC tumors. The presence of exhausted TRM cells expressing PD-1 and TIGIT suggests that dual checkpoint receptor blockade could be a promising avenue for future immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Felicity Liew, Shubha Talwar, Andy Cross, Brian J. Willett, Sam Scott, Nicola Logan, Matthew K. Siggins, Dawid Swieboda, Jasmin K. Sidhu, Claudia Efstathiou, Shona C. Moore, Chris Davis, Noura Mohamed, Jose Nunag, Clara King, A. A. Roger Thompson, Sarah L. Rowland-Jones, Annemarie B. Docherty, James D. Chalmers, Ling-Pei Ho, Alexander Horsley, Betty Raman, Krisnah Poinasamy, Michael Marks, Onn Min Kon, Luke Howard, Daniel G. Wootton, Susanna Dunachie, Jennifer K. Quint, Rachael A. Evans, Louise V. Wain, Sara Fontanella, Thushan I. de Silva, Antonia Ho, Ewen Harrison, J. Kenneth Baillie, Malcolm G. Semple, Christopher Brightling, Ryan S. Thwaites, Lance Turtle, Peter J. M. Openshaw
Summary: This study examined the nasal and plasma antibody responses in COVID-19 hospitalized patients one year after discharge and vaccination. The findings showed sustained elevated antibody responses in both nasal and plasma samples for at least 12 months, but the nasal antibody response was minimally influenced by vaccination. These findings highlight the importance of developing vaccines that enhance nasal immunity.
Article
Infectious Diseases
Alexander C. Dowell, Gokhan Tut, Jusnara Begum, Rachel Bruton, Christopher Bentley, Megan Butler, Grace Uwenedi, Jianmin Zuo, Annabel A. Powell, Andrew J. Brent, Bernadette Brent, Frances Baawuah, Ifeanyichukwu Okike, Joanne Beckmann, Shazaad Ahmad, Felicity Aiano, Joanna Garstang, Mary E. Ramsay, Paul Moss, Shamez N. Ladhani
Summary: Repeated coronavirus infections in childhood contribute to the maturation of immune responses. IgA antibody responses in children against coronaviruses are lower compared to adults, although the relative neutralization capacity is similar. Reinfection with SARS-CoV-2 enhances mucosal IgA responses, while vaccination has a more modest impact. Developing mucosal vaccines against coronaviruses in children is therefore particularly important.
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
Alexander C. Dowell, Dagmar Waiblinger, John Wright, Shamez N. Ladhani, Paul Moss
JOURNAL OF INFECTION
(2023)
Editorial Material
Immunology
Helen McShane
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Alexander C. Dowell, Tara Lancaster, Rachel Bruton, Georgina Ireland, Christopher Bentley, Panagiota Sylla, Jianmin Zuo, Sam Scott, Azar Jadir, Jusnara Begum, Thomas Roberts, Christine Stephens, Shabana Ditta, Rebecca Shepherdson, Annabel A. Powell, Andrew J. Brent, Bernadette Brent, Frances Baawuah, Ifeanyichukwu Okike, Joanne Beckmann, Shazaad Ahmad, Felicity Aiano, Joanna Garstang, Mary E. Ramsay, Rafaq Azad, Dagmar Waiblinger, Brian Willett, John Wright, Shamez N. Ladhani, Paul Moss
Summary: Omicron variants of SARS-CoV-2 are dominant globally and highly infectious in children. Initial Omicron infection triggers a weak antibody response, but subsequent reinfection or vaccination results in increased antibody levels and broad neutralization of Omicron subvariants. Previous infection with pre-Omicron strains or vaccination primes for strong antibody responses following Omicron infection, albeit primarily targeting ancestral variants. Cellular responses are robust and equivalent across all groups, providing protection against severe disease regardless of the SARS-CoV-2 variant. Immunological imprinting may play a vital role in long-term humoral immunity, but its clinical significance is uncertain.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Vicki S. Barber, Nicholas Peckham, Lelia Duley, Anne Francis, Abhishek Abhishek, Paul Moss, Jonathan A. Cook, Helen M. Parry
Summary: This study aims to determine if a pause in BTKi therapy improves vaccine immune response in CLL patients before receiving a SARS-CoV-2 vaccine booster.
Article
Biology
Wayne Croft, Hayden Pearce, Sandra Margielewska-Davies, Lindsay Lim, Samantha M. Nicol, Fouzia Zayou, Daniel Blakeway, Francesca Marcon, Sarah Powell-Brett, Brinder Mahon, Reena Merard, Jianmin Zuo, Gary Middleton, Keith Roberts, Rachel M. Brown, Paul Moss
Summary: Pancreatic ductal adenocarcinoma has poor clinical outcome and limited response to immunotherapy. Stromal fibroblasts play a dominant role in the tumor microenvironment and exhibit high transcriptional heterogeneity influenced by tumor proximity. Targeting tumor-proximal fibroblast subsets, along with HIF-1 alpha inhibition and immune stimulation, may offer a multimodal therapeutic approach for this disease.
Article
Critical Care Medicine
Nazlihan Boyaci Dundar, David Sarphie, Kenan Yuce, Ummugulsum Gaygisiz, O. Tolga Kaskati, Melda Turkoglu, Gulbin Aygencel Bikmaz, Lale Karabiyik, Kayhan Caglar, Gulendam Bozdayi, Rubina Mian, Paul Moss, Mustafa Necmi Ilhan
Summary: The functional measurement of reactive oxygen species (ROS) produced by neutrophils in the blood of COVID-19 patients has the potential to predict patient survival outcomes and to serve as a clinical tool for predicting disease progression and guiding treatment.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Article
Rheumatology
C. King, R. Patel, C. Mendoza, J. K. Walker, E. Y. Wu, P. Moss, M. D. Morgan, D. O'Dell Bunch, L. Harper, D. Chanouzas
Summary: This study examines whether past exposure to cytomegalovirus (CMV) is a risk factor for venous thromboembolism (VTE) in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV). The study found that past CMV infection is an independent risk factor associated with VTE in AAV patients.
ARTHRITIS RESEARCH & THERAPY
(2022)
