Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The level of origin firing inversely affects the rate of replication fork progression

(2013) Yuan Zhong et al.   JOURNAL OF CELL BIOLOGY

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment

(2013) Britta Will et al.   NATURE IMMUNOLOGY

Lnk deficiency partially mitigates hematopoietic stem cell aging

(2012) Alexey Bersenev et al.   AGING CELL

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

(2011) Gudmundur L. Norddahl et al.   Cell Stem Cell

Ribosome defects in disorders of erythropoiesis

(2011) Anupama Narla et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Cell cycle regulation in hematopoietic stem cells

(2011) Eric M. Pietras et al.   JOURNAL OF CELL BIOLOGY

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trf1 Is Not Required for Proliferation or Functional Telomere Maintenance in Chicken DT40 Cells

(2009) Carol Cooley et al.   MOLECULAR BIOLOGY OF THE CELL

Cohesin acetylation speeds the replication fork

(2009) Marie-Emilie Terret et al.   NATURE

The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication

(2009) Tomás Aparicio et al.   NUCLEIC ACIDS RESEARCH

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint

(2008) Shinichiro Nakada et al.   EMBO REPORTS

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA