Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle

Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle

(2015) S. K. Powell et al.   EMBO JOURNAL

Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

(2015) Marco Demaria et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

(2015) Silvia Alvarez et al.   Nature Communications

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication

(2015) FuJung Chang et al.   eLife

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Helicase loading: How to build a MCM2-7 double-hexamer

(2014) Alberto Riera et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genetic and epigenetic determinants of DNA replication origins, position and activation

(2013) Marcel Méchali et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Loading strategies of ring-shaped nucleic acid translocases and helicases

(2013) Valerie L O'Shea et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly

(2013) Alejandra Fernández-Cid et al.   MOLECULAR CELL

Mechanisms regulating epidermal stem cells

(2012) Benjamin Beck et al.   EMBO JOURNAL

PITT: Pronuclear Injection-Based Targeted Transgenesis, a Reliable Transgene Expression Method in Mice

(2012) Masato OHTSUKA et al.   EXPERIMENTAL ANIMALS

Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication

(2012) M. Hossain et al.   GENES & DEVELOPMENT

New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

(2012) Maksim V. Plikus   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

(2011) Maria Sideridou et al.   JOURNAL OF CELL BIOLOGY

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

(2011) Tsuyoshi Kawabata et al.   MOLECULAR CELL

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

(2011) Duane L Guernsey et al.   NATURE GENETICS

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

Mutations in the pre-replication complex cause Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

DNA damage response and tumorigenesis in Mcm2-deficient mice

(2010) D Kunnev et al.   ONCOGENE

Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

(2010) Chen-Hua Chuang et al.   PLoS Genetics

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

(2008) Irene García-Higuera et al.   NATURE CELL BIOLOGY

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA