标题
Exploiting replicative stress to treat cancer
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 14, Issue 6, Pages 405-423
出版商
Springer Nature
发表日期
2015-05-08
DOI
10.1038/nrd4553
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- A rapid and efficient method to purify proteins at replication forks under native conditions
- (2016) Kai Him Thomas Leung et al. BIOTECHNIQUES
- Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells
- (2015) Mikhail V. Blagosklonny Oncotarget
- Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer
- (2015) Suyoun Chung et al. Oncotarget
- Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970
- (2015) Amy B. Hall et al. Oncotarget
- Cancer phenotypic lethality, exemplified by the non-essential MTH1 enzyme being required for cancer survival
- (2014) T. Helleday ANNALS OF ONCOLOGY
- The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor
- (2014) Yong-Soon Cho et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors
- (2014) Edward Sausville et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Regulation and roles of Cdc7 kinase under replication stress
- (2014) Masayuki Yamada et al. CELL CYCLE
- The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells
- (2014) Frederik Köpper et al. CELL CYCLE
- Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
- (2014) K. Garcia et al. MOLECULAR CANCER THERAPEUTICS
- Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
- (2014) Kilian V. M. Huber et al. NATURE
- MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- (2014) Helge Gad et al. NATURE
- Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
- (2014) Constance Alabert et al. NATURE CELL BIOLOGY
- Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction
- (2014) Aidan G Gilmartin et al. Nature Chemical Biology
- Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins
- (2014) Yongxing Gong et al. NATURE GENETICS
- Tackling the cancer stem cells — what challenges do they pose?
- (2014) Diwakar R. Pattabiraman et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting tumour-supportive cellular machineries in anticancer drug development
- (2014) Matthias Dobbelstein et al. NATURE REVIEWS DRUG DISCOVERY
- Drugging the p53 pathway: understanding the route to clinical efficacy
- (2014) Kian Hoe Khoo et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting bromodomains: epigenetic readers of lysine acetylation
- (2014) Panagis Filippakopoulos et al. NATURE REVIEWS DRUG DISCOVERY
- RNAi screening comes of age: improved techniques and complementary approaches
- (2014) Stephanie E. Mohr et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair
- (2014) Junya Unno et al. Cell Reports
- p53-Based cyclotherapy: exploiting the ‘guardian of the genome’ to protect normal cells from cytotoxic therapy
- (2013) B Rao et al. BRITISH JOURNAL OF CANCER
- Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours
- (2013) Takashi Seto et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Portrait of replication stress viewed from telomeres
- (2013) Fuyuki Ishikawa CANCER SCIENCE
- Identification of Early Replicating Fragile Sites that Contribute to Genome Instability
- (2013) Jacqueline H. Barlow et al. CELL
- Mechanisms Governing Metastatic Dormancy and Reactivation
- (2013) Filippo G. Giancotti CELL
- ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
- (2013) Luis Ignacio Toledo et al. CELL
- MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells
- (2013) Suyoun Chung et al. CELL CYCLE
- Wee1 kinase as a target for cancer therapy
- (2013) Khanh Do et al. CELL CYCLE
- Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
- (2013) L Bracci et al. CELL DEATH AND DIFFERENTIATION
- Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy
- (2013) V. Nogueira et al. CLINICAL CANCER RESEARCH
- Personalized Cancer Medicine: Molecular Diagnostics, Predictive biomarkers, and Drug Resistance
- (2013) D Gonzalez de Castro et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice
- (2013) Thomas Helleday CURRENT OPINION IN ONCOLOGY
- Negative Regulation of NEDD8 Conjugation Pathway by Novel Molecules and Agents for Anticancer Therapy
- (2013) Tomoaki Tanaka et al. CURRENT PHARMACEUTICAL DESIGN
- ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
- (2013) M. Yamada et al. GENES & DEVELOPMENT
- RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells
- (2013) R. L. Ragland et al. GENES & DEVELOPMENT
- ATR phosphorylates SMARCAL1 to prevent replication fork collapse
- (2013) F. B. Couch et al. GENES & DEVELOPMENT
- CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo
- (2013) L. Chaudhuri et al. HAEMATOLOGICA
- Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells
- (2013) Cenk Kig et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Proteins at Active, Stalled, and Collapsed Replication Forks Using Isolation of Proteins on Nascent DNA (iPOND) Coupled with Mass Spectrometry
- (2013) Bianca M. Sirbu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine
- (2013) J. Fredebohm et al. JOURNAL OF CELL SCIENCE
- Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally
- (2013) M. Yekezare et al. JOURNAL OF CELL SCIENCE
- Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity
- (2013) Kevin M. Foote et al. JOURNAL OF MEDICINAL CHEMISTRY
- The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
- (2013) Shahneen K Sandhu et al. LANCET ONCOLOGY
- Diminished Origin-Licensing Capacity Specifically Sensitizes Tumor Cells to Replication Stress
- (2013) Kristin M. Zimmerman et al. MOLECULAR CANCER RESEARCH
- The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling
- (2013) Matthias Altmeyer et al. MOLECULAR CELL
- PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication
- (2013) Julie Bianchi et al. MOLECULAR CELL
- PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry
- (2013) Alexandre Maréchal et al. MOLECULAR CELL
- Replication stress links structural and numerical cancer chromosomal instability
- (2013) Rebecca A. Burrell et al. NATURE
- Causes and consequences of replication stress
- (2013) Michelle K. Zeman et al. NATURE CELL BIOLOGY
- Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
- (2013) Matteo Berti et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Repriming of DNA synthesis at stalled replication forks by human PrimPol
- (2013) Silvana Mourón et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcription-replication encounters, consequences and genomic instability
- (2013) Anne Helmrich et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- 5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
- (2013) Manuel Luís Orta et al. NUCLEIC ACIDS RESEARCH
- Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
- (2013) F. Kopper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
- (2013) Lorenzo Costantino et al. SCIENCE
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- Many faces of DAMPs in cancer therapy
- (2013) O Krysko et al. Cell Death & Disease
- Heterozygous mutations in PALB2 cause DNA replication and damage response defects
- (2013) Jenni Nikkilä et al. Nature Communications
- BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia
- (2013) D Da Costa et al. Blood Cancer Journal
- A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules
- (2013) Andres J. Lopez-Contreras et al. Cell Reports
- A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo
- (2013) Sandra Morandell et al. Cell Reports
- 5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint
- (2013) Giulio Donati et al. Cell Reports
- Drugging Topoisomerases: Lessons and Challenges
- (2012) Yves Pommier ACS Chemical Biology
- A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer
- (2012) Cynthia X. Ma et al. BREAST CANCER RESEARCH AND TREATMENT
- The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy
- (2012) Remko Prevo et al. CANCER BIOLOGY & THERAPY
- Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924
- (2012) Michael A. Milhollen et al. CANCER CELL
- Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition
- (2012) Amy D Guertin et al. Cancer Cell International
- Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
- (2012) M. R. Russell et al. CANCER RESEARCH
- MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
- (2012) W.-J. Wang et al. CANCER RESEARCH
- Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1
- (2012) S. Ying et al. CANCER RESEARCH
- Epigenetic Resensitization to Platinum in Ovarian Cancer
- (2012) D. Matei et al. CANCER RESEARCH
- Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development
- (2012) Martin A.M. Reijns et al. CELL
- An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells
- (2012) Ingeborg M.M. van Leeuwen et al. CELL CYCLE
- Combined inhibition of Chk1 and Wee1: In vitro synergistic effect translates to tumor growth inhibition in vivo
- (2012) Laura Carrassa et al. CELL CYCLE
- Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias
- (2012) J. E. Karp et al. CLINICAL CANCER RESEARCH
- Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair
- (2012) Koichi Sato et al. EMBO JOURNAL
- MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy
- (2012) Steffan T Nawrocki et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
- (2012) Cynthia X. Ma et al. JOURNAL OF CLINICAL INVESTIGATION
- Preoperative Versus Postoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-Up of 11 Years
- (2012) Rolf Sauer et al. JOURNAL OF CLINICAL ONCOLOGY
- An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
- (2012) Andres J. López-Contreras et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
- (2012) Isabelle Ray-Coquard et al. LANCET ONCOLOGY
- Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption
- (2012) H. Beck et al. MOLECULAR AND CELLULAR BIOLOGY
- Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents
- (2012) Y. Kee et al. MOLECULAR CANCER RESEARCH
- Systematic identification of genomic markers of drug sensitivity in cancer cells
- (2012) Mathew J. Garnett et al. NATURE
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination
- (2012) Xing Zeng et al. Nature Chemical Biology
- Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA
- (2012) Bianca M Sirbu et al. Nature Protocols
- Patient-derived tumour xenografts as models for oncology drug development
- (2012) John J. Tentler et al. Nature Reviews Clinical Oncology
- Targeting IAP proteins for therapeutic intervention in cancer
- (2012) Simone Fulda et al. NATURE REVIEWS DRUG DISCOVERY
- Y-family DNA polymerases and their role in tolerance of cellular DNA damage
- (2012) Julian E. Sale et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Topoisomerase I poisoning results in PARP-mediated replication fork reversal
- (2012) Arnab Ray Chaudhuri et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
- (2012) Jonathan Ledermann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
- (2012) Petra Groth et al. NUCLEIC ACIDS RESEARCH
- RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells
- (2012) Brian Budke et al. NUCLEIC ACIDS RESEARCH
- A switch between DNA polymerases and promotes error-free bypass of 8-oxo-G lesions
- (2012) E. Markkanen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA
- (2012) T. Forshew et al. Science Translational Medicine
- A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer
- (2012) R. Chugh et al. Science Translational Medicine
- Regulation of p73 activity by post-translational modifications
- (2012) F Conforti et al. Cell Death & Disease
- Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation
- (2012) E Fokas et al. Cell Death & Disease
- Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1
- (2012) Marieke Aarts et al. Cancer Discovery
- A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924
- (2012) Julia I. Toth et al. Cell Reports
- Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening
- (2011) Fei Huang et al. ACS Chemical Biology
- Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines
- (2011) A Peasland et al. BRITISH JOURNAL OF CANCER
- Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation
- (2011) Kurtis D. Davies et al. CANCER BIOLOGY & THERAPY
- Translesion DNA synthesis in the context of cancer research
- (2011) Philip A Knobel et al. Cancer Cell International
- Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover
- (2011) M. A. Milhollen et al. CANCER RESEARCH
- CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors
- (2011) Victoria E. Anderson et al. CANCER RESEARCH
- Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
- (2011) Assaf C. Bester et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin
- (2011) Shin-ichi Sato et al. CHEMISTRY & BIOLOGY
- Rescue of replication failure by Fanconi anaemia proteins
- (2011) Angelos Constantinou CHROMOSOMA
- Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells
- (2011) A. Hoglund et al. CLINICAL CANCER RESEARCH
- MK-1775, a Potent Wee1 Inhibitor, Synergizes with Gemcitabine to Achieve Tumor Regressions, Selectively in p53-Deficient Pancreatic Cancer Xenografts
- (2011) N. V. Rajeshkumar et al. CLINICAL CANCER RESEARCH
- Analysis of protein dynamics at active, stalled, and collapsed replication forks
- (2011) B. M. Sirbu et al. GENES & DEVELOPMENT
- Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes
- (2011) Marie Regairaz et al. JOURNAL OF CELL BIOLOGY
- SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
- (2011) Stine Jørgensen et al. JOURNAL OF CELL BIOLOGY
- Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR
- (2011) David W. Schoppy et al. JOURNAL OF CLINICAL INVESTIGATION
- Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
- (2011) Karen A Gelmon et al. LANCET ONCOLOGY
- Hsp90 Inhibitor-Mediated Disruption of Chaperone Association of ATR with Hsp90 Sensitizes Cancer Cells to DNA Damage
- (2011) K. Ha et al. MOLECULAR CANCER THERAPEUTICS
- Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
- (2011) T. J. Guzi et al. MOLECULAR CANCER THERAPEUTICS
- Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes
- (2011) Anne Helmrich et al. MOLECULAR CELL
- A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction
- (2011) Malavika Raman et al. MOLECULAR CELL
- BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage
- (2011) Shailja Pathania et al. MOLECULAR CELL
- Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs
- (2011) Luis I. Toledo et al. Molecular Oncology
- Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
- (2011) Philip M Reaper et al. Nature Chemical Biology
- Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
- (2011) Matilde Murga et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
- (2011) C. S. Sorensen et al. NUCLEIC ACIDS RESEARCH
- ATR mediates cisplatin resistance in a p53 genotype-specific manner
- (2011) N Sangster-Guity et al. ONCOGENE
- Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes
- (2011) Ulrike Beyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- How dormant origins promote complete genome replication
- (2011) J. Julian Blow et al. TRENDS IN BIOCHEMICAL SCIENCES
- Targeting DNA Replication before it Starts
- (2010) Sara Rodriguez-Acebes et al. AMERICAN JOURNAL OF PATHOLOGY
- In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma
- (2010) Shahryar E. Mir et al. CANCER CELL
- Inhibition of Histone Deacetylase in Cancer Cells Slows Down Replication Forks, Activates Dormant Origins, and Induces DNA Damage
- (2010) Chiara Conti et al. CANCER RESEARCH
- Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo
- (2010) L. W. Hebbard et al. CANCER RESEARCH
- NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells
- (2010) J. J. Lin et al. CANCER RESEARCH
- High-throughput siRNA screens using γH2AX as marker uncover key regulators of genome integrity in mammalian cells
- (2010) Halfdan Beck et al. CELL CYCLE
- Hsp90 phosphorylation, Wee1 and the cell cycle
- (2010) Mehdi Mollapour et al. CELL CYCLE
- Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy
- (2010) A. Montagnoli et al. CLINICAL CANCER RESEARCH
- Oncogene-induced senescence: the bright and dark side of the response
- (2010) Vassilis G Gorgoulis et al. CURRENT OPINION IN CELL BIOLOGY
- Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine
- (2010) Barbara van Loon et al. DNA REPAIR
- RNAi-based screening identifies the Mms22L–Nfkbil2 complex as a novel regulator of DNA replication in human cells
- (2010) Wojciech Piwko et al. EMBO JOURNAL
- A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial
- (2010) Tianhong Li et al. INVESTIGATIONAL NEW DRUGS
- ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
- (2010) Carolyn J. McNees et al. JOURNAL OF CELL BIOLOGY
- Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
- (2010) Halfdan Beck et al. JOURNAL OF CELL BIOLOGY
- DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
- (2010) H. Christian Reinhardt et al. MOLECULAR CELL
- Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
- (2010) Eva Petermann et al. MOLECULAR CELL
- CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase
- (2010) Richard C. Centore et al. MOLECULAR CELL
- CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation
- (2010) Tarek Abbas et al. MOLECULAR CELL
- Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function
- (2010) Mehdi Mollapour et al. MOLECULAR CELL
- The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
- (2010) Yi-Jun Sheu et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells
- (2010) Mathieu Tardat et al. NATURE CELL BIOLOGY
- Pathways of mammalian replication fork restart
- (2010) Eva Petermann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Maintaining genome stability at the replication fork
- (2010) Dana Branzei et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Genomic instability — an evolving hallmark of cancer
- (2010) Simona Negrini et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication
- (2010) I. G. Cannell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chk1 promotes replication fork progression by controlling replication initiation
- (2010) E. Petermann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aberrant expression of alternative DNA polymerases: A source of mutator phenotype as well as replicative stress in cancer
- (2010) Jean-Sébastien Hoffmann et al. SEMINARS IN CANCER BIOLOGY
- Targeting homologous recombination repair defects in cancer
- (2010) Bastiaan Evers et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Defining replication origin efficiency using DNA fiber assays
- (2009) Sandie Tuduri et al. CHROMOSOME RESEARCH
- Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
- (2009) H Christian Reinhardt et al. CURRENT OPINION IN CELL BIOLOGY
- Control of the G2/M checkpoints after exposure to low doses of ionising radiation: Implications for hyper-radiosensitivity
- (2009) Marie Fernet et al. DNA REPAIR
- PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
- (2009) Helen E Bryant et al. EMBO JOURNAL
- Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
- (2009) P. Martinez et al. GENES & DEVELOPMENT
- ATR signaling at a glance
- (2009) B. Shiotani et al. JOURNAL OF CELL SCIENCE
- Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer
- (2009) David O Azorsa et al. Journal of Translational Medicine
- Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
- (2009) H. Hirai et al. MOLECULAR CANCER THERAPEUTICS
- Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry
- (2009) Li-Chiou Chuang et al. MOLECULAR CELL
- A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability
- (2009) Renee D. Paulsen et al. MOLECULAR CELL
- Association of reactive oxygen species levels and radioresistance in cancer stem cells
- (2009) Maximilian Diehn et al. NATURE
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
- (2009) Teresa A. Soucy et al. NATURE
- A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
- (2009) Matilde Murga et al. NATURE GENETICS
- Cell cycle kinases as therapeutic targets for cancer
- (2009) Silvia Lapenna et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs
- (2009) Mayte Coiras et al. NATURE REVIEWS MICROBIOLOGY
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- Argyrin A Reveals a Critical Role for the Tumor Suppressor Protein p27kip1 in Mediating Antitumor Activities in Response to Proteasome Inhibition
- (2008) Irina Nickeleit et al. CANCER CELL
- A History of Cancer Chemotherapy
- (2008) Vincent T. DeVita et al. CANCER RESEARCH
- BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways
- (2008) Dominique Kranz et al. JOURNAL OF CELL BIOLOGY
- DNA Replication Arrest in Response to Genotoxic Stress Provokes Early Activation of Stress-Activated Protein Kinases (SAPK/JNK)
- (2008) Julia Damrot et al. JOURNAL OF MOLECULAR BIOLOGY
- A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex
- (2008) Aude Dupré et al. Nature Chemical Biology
- A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
- (2008) Alessia Montagnoli et al. Nature Chemical Biology
- ATR: an essential regulator of genome integrity
- (2008) Karlene A. Cimprich et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Nucleoside analogs: molecular mechanisms signaling cell death
- (2008) B Ewald et al. ONCOGENE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started