Oxidative Phosphorylation—an Update on a New, Essential Target Space for Drug Discovery in Mycobacterium tuberculosis

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds

(2020) Garrett C. Moraski et al.   PLoS One

Targeting the cytochrome oxidases for drug development in mycobacteria

(2020) Bei Shi Lee et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

(2020) Andréanne Lupien et al.   PLoS Pathogens

High Prevalence of Bedaquiline Resistance in Treatment-naïve Tuberculosis Patients and Verapamil Effectiveness

(2019) Hasan Ghajavand et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

(2019) Albert Byungyun Jeon et al.   Scientific Reports

The structure of the catalytic domain of the ATP synthase fromMycobacterium smegmatisis a target for developing antitubercular drugs

(2019) Alice Tianbu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro and in vivo activities of the riminophenazine TBI-166 against Mycobacterium tuberculosis

(2019) Jian Xu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identifying regimens containing a new drug candidate TBI-166 against Mycobacterium tuberculosis in vitro and in vivo

(2019) Ye Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Shortening Buruli ulcer treatment with combination therapy targeting the respiratory chain and exploiting M. ulcerans gene decay

(2019) Paul J. Converse et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors

(2019) Bryan J. Berube et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

(2019) Adrian Blaser et al.   BIOORGANIC & MEDICINAL CHEMISTRY

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

(2019) Hamish S. Sutherland et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

(2019) Kelly Flentie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid

(2019) Van den Bossche An et al.   TUBERCULOSIS

TBAJ-876 retains Bedaquiline's activity against subunit c and ϵ of Mycobacterium tuberculosis F-ATP synthase

(2019) Jickky Palmae Sarathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Surveillance of adverse events in the treatment of drug-resistant tuberculosis: A global feasibility study

(2019) Onno Akkerman et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis

(2019) Rakesh K. Dhiman et al.   PLoS One

A Therapeutic Role for the F1FO-ATP Synthase

(2019) Salvatore Nesci et al.   SLAS Discovery

The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents

(2019) Kristiana T. Santoso et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis

(2019) Gregory A. Harrison et al.   mSphere

Surveillance of adverse events in the treatment of drug-resistant tuberculosis: first global report

(2019) Sergey Borisov et al.   EUROPEAN RESPIRATORY JOURNAL

Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents

(2019) Kiel Hards et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Cytochrome bd in Mycobacterium tuberculosis: A respiratory chain protein involved in the defense against antibacterials

(2019) Ludovica Mascolo et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Active site rearrangement and structural divergence in prokaryotic respiratory oxidases

(2019) S. Safarian et al.   SCIENCE

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development

(2019) Tiago Beites et al.   Nature Communications

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

(2019) Wuan-Geok Saw et al.   Scientific Reports

Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity

(2018) Michael B. Harbut et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

(2018) Hamish S. Sutherland et al.   BIOORGANIC & MEDICINAL CHEMISTRY

QT prolongation and cardiac toxicity of new tuberculosis drugs in Europe: A Tuberculosis Network European Trialsgroup (TBnet) study

(2018) Lorenzo Guglielmetti et al.   EUROPEAN RESPIRATORY JOURNAL

The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine

(2018) Shin Joon et al.   FEBS Journal

Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing

(2018) Fernanda Teixeira Subtil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

(2018) Laura A. T. Cleghorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Plasticity ofMycobacterium tuberculosisNADH dehydrogenases and their role in virulence

(2018) Catherine Vilchèze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ionophoric effects of the antitubercular drug bedaquiline

(2018) Kiel Hards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening of antitubercular compound library identifies novel ATP synthase inhibitors of Mycobacterium tuberculosis

(2018) Sunil Kumar et al.   TUBERCULOSIS

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd

(2018) Ping Lu et al.   Scientific Reports

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

(2018) Dinakaran Murugesan et al.   ACS Infectious Diseases

Target Engagement and Binding Mode of an Antituberculosis Drug to Its Bacterial Target Deciphered in Whole Living Cells by NMR

(2018) Guillaume Bouvier et al.   BIOCHEMISTRY

Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria

(2018) Bei Shi Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a functional obligate complex III2IV2 respiratory supercomplex from Mycobacterium smegmatis

(2018) Benjamin Wiseman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

(2018) Hongri Gong et al.   SCIENCE

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

(2018) Caroline S. Foo et al.   mBio

Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer

(2018) Nicole Scherr et al.   Nature Communications

Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis

(2018) Xiaoyun Lu et al.   ACS Infectious Diseases

Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity

(2017) Xiaoyun Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis

(2017) Bruno Couto Giacobbo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Examination of bedaquiline- and linezolid-resistant Mycobacterium tuberculosis isolates from the Moscow region

(2017) Danila V. Zimenkov et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation

(2017) Priya Ragunathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

(2017) Subramanyam J. Tantry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploiting the synthetic lethality between terminal respiratory oxidases to killMycobacterium tuberculosisand clear host infection

(2017) Nitin P. Kalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

(2017) Michael A. DeJesus et al.   mBio

A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

(2017) Paridhi Sukheja et al.   mBio

Targeting Energy Metabolism in Mycobacterium tuberculosis , a New Paradigm in Antimycobacterial Drug Discovery

(2017) Dirk Bald et al.   mBio

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

(2017) Amy S. T. Tong et al.   ACS Medicinal Chemistry Letters

Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages

(2017) Sandra Billig et al.   Scientific Reports

Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort

(2017) Tom A. Yates et al.   PLOS MEDICINE

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB

(2017) N. Susantha Chandrasekera et al.   ACS Infectious Diseases

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

(2017) Albert B. Jeon et al.   PLoS One

Novel long-chain compounds with both immunomodulatory and MenA inhibitory activities against Staphylococcus aureus and its biofilm

(2017) Seoung-ryoung Choi et al.   Scientific Reports

Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival

(2017) Teresa Cortes et al.   Scientific Reports

Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium InfectionIn Vivo

(2016) Garrett C. Moraski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mutations inpepQConfer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis

(2016) Deepak Almeida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Deletion of a unique loop in the mycobacterial F-ATP synthase γ subunit sheds light on its inhibitory role in ATP hydrolysis-driven H+pumping

(2016) Adam Hotra et al.   FEBS Journal

Discovery of bicyclic inhibitors against menaquinone biosynthesis

(2016) Seoung-ryoung Choi et al.   Future Medicinal Chemistry

Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death

(2016) Adam Heikal et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides

(2016) Eleni Pitta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases

(2016) Schara Safarian et al.   SCIENCE

Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms

(2016) Ehab N.M. Jirgis et al.   STRUCTURE

SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc1 inhibitors

(2016) Narisa Phummarin et al.   MedChemComm

2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

(2016) Kenia Pissinate et al.   ACS Medicinal Chemistry Letters

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

(2016) Dirk A. Lamprecht et al.   Nature Communications

Arrival of Imidazo[2,1-b]thiazole-5-carboxamides: Potent Anti-tuberculosis Agents That Target QcrB

(2016) Garrett C. Moraski et al.   ACS Infectious Diseases

The CydDC ABC transporter of Escherichia coli: new roles for a reductant efflux pump

(2015) M. Shepherd   BIOCHEMICAL SOCIETY TRANSACTIONS

Synthesis and bio-evaluation of phenothiazine derivatives as new anti-tuberculosis agents

(2015) Chun-Xian He et al.   CHINESE CHEMICAL LETTERS

Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients

(2015) Norbert Heinrich et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Isolation and Characterization of a Hybrid Respiratory Supercomplex Consisting ofMycobacterium tuberculosisCytochromebccandMycobacterium smegmatisCytochromeaa3

(2015) Mi-Sun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity

(2015) N. Susantha Chandrasekera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration

(2015) Renier van der Westhuyzen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Profiling the Proteome ofMycobacterium tuberculosisduring Dormancy and Reactivation

(2015) Vipin Gopinath et al.   MOLECULAR & CELLULAR PROTEOMICS

Antiinfectives targeting enzymes and the proton motive force

(2015) Xinxin Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents

(2015) Jian Tang et al.   ACS Medicinal Chemistry Letters

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

(2015) Jan Rybniker et al.   Nature Communications

Tuberculosis Treatment and Drug Regimens

(2015) G. Sotgiu et al.   Cold Spring Harbor Perspectives in Medicine

Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil

(2015) Tatiane Coelho et al.   Frontiers in Microbiology

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline

(2015) L. Preiss et al.   Science Advances

Efflux Pump Gene Expression in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates

(2015) Guilian Li et al.   PLoS One

The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress

(2015) Ping Lu et al.   Scientific Reports

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis

(2014) R. C. Hartkoorn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Respiratory Flexibility in Response to Inhibition of CytochromecOxidase in Mycobacterium tuberculosis

(2014) Kriti Arora et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ATP synthase in mycobacteria: Special features and implications for a function as drug target

(2014) Ping Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Scaffold-switching: An exploration of 5,6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo[1,2-a]pyridine-3-carboxylates

(2014) Garrett C. Moraski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Conservation analysis of the CydX protein yields insights into small protein identification and evolution

(2014) Rondine J Allen et al.   BMC GENOMICS

Novel non-neuroleptic phenothiazines inhibit Mycobacterium tuberculosis replication

(2014) Sumayah Salie et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Verapamil, and Its Metabolite Norverapamil, Inhibit Macrophage-induced, Bacterial Efflux Pump-mediated Tolerance to Multiple Anti-tubercular Drugs

(2014) Kristin N. Adams et al.   JOURNAL OF INFECTIOUS DISEASES

Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent

(2014) Sunhee Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

(2014) Kai Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Novel 2-Methoxypyridylamino-Substituted Riminophenazine Derivatives as Antituberculosis Agents

(2014) Dongfeng Zhang et al.   MOLECULES

Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline

(2014) Koen Andries et al.   PLoS One

A Mycobacterium tuberculosis Cytochrome bd Oxidase Mutant Is Hypersensitive to Bedaquiline

(2014) M. Berney et al.   mBio

Essentiality of Succinate Dehydrogenase in Mycobacterium smegmatis and Its Role in the Generation of the Membrane Potential Under Hypoxia

(2014) I. Pecsi et al.   mBio

Succinate Dehydrogenase is the Regulator of Respiration in Mycobacterium tuberculosis

(2014) Travis Hartman et al.   PLoS Pathogens

The ATP synthase: the understood, the uncertain and the unknown

(2013) John E. Walker   BIOCHEMICAL SOCIETY TRANSACTIONS

Defining a direction: Electron transfer and catalysis in Escherichia coli complex II enzymes

(2013) Elena Maklashina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

(2013) Katherine A. Abrahams et al.   PLoS One

Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?

(2013) Robert C. Goldman   TUBERCULOSIS

Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis

(2013) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

(2012) Puiying A. Mak et al.   ACS Chemical Biology

Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis

(2012) Joy Debnath et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

(2012) Diana Machado et al.   PLoS One

Quinolinyl Pyrimidines: Potent Inhibitors of NDH-2 as a Novel Class of Anti-TB Agents

(2012) Pravin S. Shirude et al.   ACS Medicinal Chemistry Letters

Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels

(2011) Ping Lu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The cytochrome bd respiratory oxygen reductases

(2011) Vitaliy B. Borisov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Stable Analogues of OSB-AMP: Potent Inhibitors of MenE, the o-Succinylbenzoate-CoA Synthetase from Bacterial Menaquinone Biosynthesis

(2011) Xuequan Lu et al.   CHEMBIOCHEM

Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase

(2011) Anna C. Haagsma et al.   PLoS One

CoA Adducts of 4-Oxo-4-phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway

(2011) Xiaokai Li et al.   ACS Medicinal Chemistry Letters

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

(2011) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity

(2011) Seung-Hun Baek et al.   PLOS BIOLOGY

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Succinylphosphonate Esters Are Competitive Inhibitors of MenD That Show Active-Site Discrimination between Homologous α-Ketoglutarate-Decarboxylating Enzymes

(2010) Maohai Fang et al.   BIOCHEMISTRY

The anti-cancer, anti-inflammatory and tuberculostatic activities of a series of 6,7-substituted-5,8-quinolinequinones

(2010) Benjamin J. Mulchin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Respiratory ATP synthesis: the new generation of mycobacterial drug targets?

(2010) Dirk Bald et al.   FEMS MICROBIOLOGY LETTERS

ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction

(2010) Anna C. Haagsma et al.   FEMS MICROBIOLOGY LETTERS

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

(2010) Takahiro Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

A Quinoline Antibiotic from Rhodococcus erythropolis JCM 6824

(2009) Wataru Kitagawa et al.   JOURNAL OF ANTIBIOTICS

MenA Is a Promising Drug Target for Developing Novel Lead Molecules to Combat Mycobacterium tuberculosis

(2009) Michio Kurosu et al.   Medicinal Chemistry

Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability

(2009) M. Gengenbacher et al.   MICROBIOLOGY-SGM

Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence

(2009) Rakesh K. Dhiman et al.   MOLECULAR MICROBIOLOGY

The Role of Nitric Oxide in Mycobacterial Infections

(2009) Chul-Su Yang et al.   Immune Network

Unique Rotary ATP Synthase and Its Biological Diversity

(2008) Christoph von Ballmoos et al.   Annual Review of Biophysics

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

(2008) Xuequan Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis

(2008) Anil Koul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

(2007) Marie A. Colucci et al.   ORGANIC & BIOMOLECULAR CHEMISTRY