Stable Analogues of OSB-AMP: Potent Inhibitors of MenE, the o-Succinylbenzoate-CoA Synthetase from Bacterial Menaquinone Biosynthesis

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

Kinetic and Inhibition Studies of Dihydroxybenzoate-AMP Ligase fromEscherichia coli

(2010) Alison L. Sikora et al.   BIOCHEMISTRY

Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,

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Designed Semisynthetic Protein Inhibitors of Ub/Ubl E1 Activating Enzymes

(2010) Xuequan Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

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Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

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Vitamin K2 in Electron Transport System: Are Enzymes Involved in Vitamin K2 Biosynthesis Promising Drug Targets?

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Active site remodelling accompanies thioester bond formation in the SUMO E1

(2010) Shaun K. Olsen et al.   NATURE

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

(2010) Kimie Nakagawa et al.   NATURE

Structure-based discovery of antibacterial drugs

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Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

The ATP-Dependent Amide Ligases DdaG and DdaF Assemble the Fumaramoyl-Dipeptide Scaffold of the Dapdiamide Antibiotics

(2009) Marie A. Hollenhorst et al.   BIOCHEMISTRY

An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains

(2009) Tohru Dairi   JOURNAL OF ANTIBIOTICS

Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis

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Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

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Antibiotics for Emerging Pathogens

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Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus

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Bacillus anthraciso-Succinylbenzoyl-CoA Synthetase: Reaction Kinetics and a Novel Inhibitor Mimicking Its Reaction Intermediate†

(2008) Yang Tian et al.   BIOCHEMISTRY

Mechanism of 4-Chlorobenzoate:Coenzyme A Ligase Catalysis†

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Identification and Characterization of (1R,6R)-2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate Synthase in the Menaquinone Biosynthesis of Escherichia coli†

(2008) Ming Jiang et al.   BIOCHEMISTRY

Crystal Structure and Enantiomer Selection byd-Alanyl Carrier Protein Ligase DltA fromBacillus cereus†

(2008) Liqin Du et al.   BIOCHEMISTRY

Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase†‡

(2008) Albert S. Reger et al.   BIOCHEMISTRY

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

(2008) Xuequan Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate

(2008) Alessio Ciulli et al.   CHEMBIOCHEM

Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy

(2008) Justin S. Cisar et al.   CHEMICAL SOCIETY REVIEWS

Mycobacterial Phenolic Glycolipid Virulence Factor Biosynthesis: Mechanism and Small-Molecule Inhibition of Polyketide Chain Initiation

(2008) Julian A. Ferreras et al.   CHEMISTRY & BIOLOGY

A Defect in Menadione Biosynthesis Induces Global Changes in Gene Expression in Staphylococcus aureus

(2008) C. Kohler et al.   JOURNAL OF BACTERIOLOGY

Crystal Structure of DltA

(2008) Huma Yonus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on A New Biosynthetic Pathway for Menaquinone

(2008) Haruo Seto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms

(2008) T. Hiratsuka et al.   SCIENCE