Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

(2014) Kai Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct Comparison of Xpert MTB/RIF Assay with Liquid and Solid Mycobacterial Culture for Quantification of Early Bactericidal Activity

(2013) X. A. Kayigire et al.   JOURNAL OF CLINICAL MICROBIOLOGY

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis

(2012) Emily R. Driver et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

(2012) Katherine A Sacksteder et al.   Future Microbiology

SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro

(2012) V. M. Reddy et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial

(2012) Andreas H Diacon et al.   LANCET

Rapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 (Sutezolid), TMC207, PA-824, SQ109, and Pyrazinamide

(2012) Robert S. Wallis et al.   PLoS One

Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients

(2011) A. H. Diacon et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment

(2011) Donald R. Hoff et al.   PLoS One

Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients

(2010) A. H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207

(2010) V. M. Reddy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacogenetics of Phase I and Phase II Drug Metabolism

(2009) Severine Crettol et al.   CURRENT PHARMACEUTICAL DESIGN

Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis

(2008) R. Rustomjee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4β-Hydroxycholesterol

(2008) KP Kanebratt et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug

(2004) Lee Jia et al.   BRITISH JOURNAL OF PHARMACOLOGY