3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

标题

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

作者

关键词

CFU, colony-forming units, hERG (human Ether-a-go-go Related Gene), HPLC, high-performance liquid chromatography, LDA, lithium diisopropylamide, LiTMP, lithium tetramethylpiperidide, LORA, low oxygen recovery assay, MABA, microplate alamar blue assay, MDR, multidrug-resistant, MIC90, minimum concentration for 90% inhibition of growth, M. tb, mycobacterium tuberculosis, TB, tuberculosis

出版物

BIOORGANIC & MEDICINAL CHEMISTRY

Volume 27, Issue 7, Pages 1292-1307

出版商

Elsevier BV

发表日期

2019-02-16

DOI

10.1016/j.bmc.2019.02.026