Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death

Bactericidal mode of action of bedaquiline

(2015) K. Hards et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

Antiinfectives targeting enzymes and the proton motive force

(2015) Xinxin Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline

(2015) L. Preiss et al.   Science Advances

Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis

(2014) Elyse A. Dunn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis

(2014) Pieter Claes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

(2014) Kai Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation

(2014) Adam Heikal et al.   MOLECULAR MICROBIOLOGY

Synthesis, Half-Wave Potentials and Antiproliferative Activity of 1-Aryl-substituted Aminoisoquinolinequinones

(2014) Juana Ibacache et al.   MOLECULES

Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent

(2014) Jason Z. Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Essentiality of Succinate Dehydrogenase in Mycobacterium smegmatis and Its Role in the Generation of the Membrane Potential Under Hypoxia

(2014) I. Pecsi et al.   mBio

Synthesis of New Quinolinequinone Derivatives and Preliminary Exploration of their Cytotoxic Properties

(2013) Charles M. Keyari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction

(2013) Catherine Vilchèze et al.   Nature Communications

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance

(2012) A. H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

(2012) Katherine A Sacksteder et al.   Future Microbiology

Totally drug-resistant tuberculosis (TDR-TB) in India: every dark cloud has a silver lining

(2012) Zarir Udwadia et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Activity of Trifluoperazine against Replicating, Non-Replicating and Drug Resistant M. tuberculosis

(2012) Meeta J. Advani et al.   PLoS One

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals

(2012) Sarah Schmidt Grant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays

(2012) Sephra N. Rampersad   SENSORS

Mycobacterium tuberculosis Dihydrofolate Reductase Is Not a Target Relevant to the Antitubercular Activity of Isoniazid

(2010) F. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The anti-cancer, anti-inflammatory and tuberculostatic activities of a series of 6,7-substituted-5,8-quinolinequinones

(2010) Benjamin J. Mulchin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

(2010) Takahiro Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis

(2010) Sean Ekins et al.   Molecular BioSystems

Metabolic Engineering of Cofactor F420 Production in Mycobacterium smegmatis

(2010) Ghader Bashiri et al.   PLoS One

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

(2009) Subramaniam Ananthan et al.   TUBERCULOSIS

Susceptibility of Mycobacterium bovis BCG Vaccine Strains to Antituberculous Antibiotics

(2008) N. Ritz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

(2007) Marie A. Colucci et al.   ORGANIC & BIOMOLECULAR CHEMISTRY