Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Apolipoprotein E4 Mediates the Association Between Midlife Dyslipidemia and Cerebral Amyloid in Aging Women

(2019) Cassandra Szoeke et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Pro - and anti-inflammatory cytokines in the CSF of Alzheimer´s disease patients and their correlation with cognitive decline

(2019) R. Taipa et al.   NEUROBIOLOGY OF AGING

It’s all about tau

(2019) Cheril Tapia-Rojas et al.   PROGRESS IN NEUROBIOLOGY

Effect of age, ethnicity, sex, cognitive status and APOE genotype on amyloid load and the threshold for amyloid positivity

(2019) R. Duara et al.   NeuroImage-Clinical

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

(2019) Katharina Meyer et al.   Cell Reports

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

(2019) Daniel Felsky et al.   Nature Communications

Another major drug candidate targeting the brain plaques of Alzheimer’s disease has failed. What’s left?

(2019) Kelly Servick   SCIENCE

Toward unrestricted use of public genomic data

(2019) Rudolf I. Amann et al.   SCIENCE

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

(2019) Mario Merlini et al.   NEURON

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

(2019) Scott Ayton et al.   MOLECULAR PSYCHIATRY

Polygenic predictors of age-related decline in cognitive ability

(2019) Stuart J. Ritchie et al.   MOLECULAR PSYCHIATRY

Dural lymphatics regulate clearance of extracellular tau from the CNS

(2019) Tirth K. Patel et al.   Molecular Neurodegeneration

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

(2019) Masaya Tachibana et al.   JOURNAL OF CLINICAL INVESTIGATION

ApoE4: an emerging therapeutic target for Alzheimer’s disease

(2019) Mirna Safieh et al.   BMC Medicine

Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease

(2019) Anil R. Wadhwani et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

(2019) Isabelle Bos et al.   Alzheimers & Dementia

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease

(2019) Suzanne E. Schindler et al.   Alzheimers & Dementia

Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

(2019) Andrea Vergallo et al.   Alzheimers & Dementia

Neuropsychiatric Symptoms as Risk Factors for Cognitive Decline in Clinically Normal Older Adults: The Cache County Study

(2019) M. Haroon Burhanullah et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

A (delayed) history of the brain lymphatic system

(2019) Stefano Sandrone et al.   NATURE MEDICINE

Tau Positron-Emission Tomography in Former National Football League Players

(2019) Robert A. Stern et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Association of Early-Onset Alzheimer Disease With Elevated Low-density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB

(2019) Thomas S. Wingo et al.   JAMA Neurology

Preventing dementia by preventing stroke: The Berlin Manifesto

(2019) Vladimir Hachinski et al.   Alzheimers & Dementia

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

(2019) Ramsey Najm et al.   Molecular Neurodegeneration

Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer’s disease

(2019) Emily R. Mahoney et al.   MOLECULAR PSYCHIATRY

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI

(2019) Frank J. Wolters et al.   NEUROLOGY

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework

(2019) Clifford R. Jack et al.   JAMA Neurology

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2019) Dimitrios Kapogiannis et al.   JAMA Neurology

The anatomy and immunology of vasculature in the central nervous system

(2019) Panagiotis Mastorakos et al.   Science Immunology

Effects of Nilvadipine on Cerebral Blood Flow in Patients With Alzheimer Disease

(2019) Daan L.K. de Jong et al.   HYPERTENSION

Connections Between Amyloid Beta and the Meningeal Lymphatics As a Possible Route for Clearance and Therapeutics

(2019) Graham Dupont et al.   Lymphatic Research and Biology

Modeling Alzheimer’s disease with iPSC-derived brain cells

(2019) Jay Penney et al.   MOLECULAR PSYCHIATRY

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

(2019) Yuetiva Deming et al.   Science Translational Medicine

cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

(2019) Shamsideen A. Ojelade et al.   Cell Reports

Is AD a Stress-Related Disorder? Focus on the HPA Axis and Its Promising Therapeutic Targets

(2019) Geoffrey Canet et al.   Frontiers in Aging Neuroscience

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

(2019) Yang Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice

(2019) Daniela Lecca et al.   NEUROBIOLOGY OF DISEASE

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

(2019) Nina E. Fultz et al.   SCIENCE

Objective subtle cognitive difficulties predict future amyloid accumulation and neurodegeneration

(2019) Kelsey R. Thomas et al.   NEUROLOGY

Meningeal lymphatics, immunity and neuroinflammation

(2019) Natalie Frederick et al.   CURRENT OPINION IN NEUROBIOLOGY

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography

(2018) Michelle M. Mielke et al.   Alzheimers & Dementia

Concomitant vascular and neurodegenerative pathologies double the risk of dementia

(2018) Mahmoud Reza Azarpazhooh et al.   Alzheimers & Dementia

APOE DNA methylation is altered in Lewy body dementia

(2018) Jessica Tulloch et al.   Alzheimers & Dementia

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

(2018) Niklas Mattsson et al.   Alzheimers & Dementia

Apolipoprotein E genotypes and longevity across dementia disorders

(2018) Tobias Skillbäck et al.   Alzheimers & Dementia

Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease

(2018) Courtney L. Sutphen et al.   Alzheimers & Dementia

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

(2018) Frances K Wiseman et al.   BRAIN

A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development

(2018) Cathy Pichol-Thievend et al.   DEVELOPMENT

A  flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform­ and cell type

(2018) Eleanna Kara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

(2018) Fan Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Technological advances and changing indications for lumbar puncture in neurological disorders

(2018) Joost M Costerus et al.   LANCET NEUROLOGY

Site Specific Evaluation of Lymphatic Vessel Sclerosis in Lower Limb Lymphedema Patients

(2018) Makoto Mihara et al.   Lymphatic Research and Biology

Lymphatic Vessel Diameter and Lymphosclerosis: Two Different Characteristics

(2018) Hayahito Sakai et al.   Lymphatic Research and Biology

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

(2018) Daniela Hartl et al.   MOLECULAR PSYCHIATRY

A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling

(2018) Shuting Zhang et al.   MOLECULAR PSYCHIATRY

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

(2018) Sara Mostafavi et al.   NATURE NEUROSCIENCE

Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease

(2018) Zhi-Bin Yao et al.   Neural Regeneration Research

Differential effects of completed and incomplete pregnancies on the risk of Alzheimer disease

(2018) Hyesue Jang et al.   NEUROLOGY

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Alzheimer’s Disease in Physicians — Assessing Professional Competence and Tempering Stigma

(2018) Gayatri Devi   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR-engineered genome editing for the next generation neurological disease modeling

(2018) Weijun Feng et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases

(2018) Bao-Liang Sun et al.   PROGRESS IN NEUROBIOLOGY

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics

(2018) Jan Verheijen et al.   TRENDS IN GENETICS

Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease

(2018) Laura M. Winchester et al.   Genome Medicine

Site Specific Evaluation of Lymphatic Vessel Sclerosis in Lower Limb Lymphedema Patients

(2018) Makoto Mihara et al.   Lymphatic Research and Biology

Lymphatic Vessel Diameter and Lymphosclerosis: Two Different Characteristics

(2018) Hayahito Sakai et al.   Lymphatic Research and Biology

Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node

(2018) Rajnish S. Dave et al.   Frontiers in Immunology

Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice

(2018) Linmei Wang et al.   BRAIN PATHOLOGY

Mechanisms of Connexin-Related Lymphedema

(2018) Jorge A. Castorena-Gonzalez et al.   CIRCULATION RESEARCH

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

(2018) Joshua C. Bis et al.   MOLECULAR PSYCHIATRY

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Rodent models for Alzheimer disease

(2018) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

(2018) Dennis W. Dickson et al.   NEUROLOGY

Definition of Late Onset Alzheimer’s Disease and Anticipation Effect of Genome-Wide Significant Risk Variants: Pilot Study of the APOE e4 Allele

(2018) Vincenzo De Luca et al.   NEUROPSYCHOBIOLOGY

Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans

(2018) Gali H. Weissberger et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

(2018) Iris J. Broce et al.   ACTA NEUROPATHOLOGICA

APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults

(2018) Melissa Lamar et al.   Alzheimers & Dementia

Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

(2018) Rosalinde E.R. Slot et al.   Alzheimers & Dementia

Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanisms

(2018) Yen-Feng Lin et al.   Alzheimers & Dementia

Vascular Risk and β -Amyloid Are Synergistically Associated with Cortical Tau

(2018) Jennifer S. Rabin et al.   ANNALS OF NEUROLOGY

Apolipoprotein E4 genotype compromises brain exosome production

(2018) Katherine Y Peng et al.   BRAIN

Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage

(2018) Xuejin Cao et al.   BRAIN RESEARCH BULLETIN

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging

(2018) Qi Yan et al.   MOLECULAR PSYCHIATRY

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

The Meningeal Lymphatic System: A New Player in Neurophysiology

(2018) Sandro Da Mesquita et al.   NEURON

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

(2018) Xunde Xian et al.   eLife

Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

(2018) Alexandra M. Wennberg et al.   JAMA Neurology

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

(2018) Rosalyn Hithersay et al.   JAMA Neurology

GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

(2018) Yuji Kajiwara et al.   Acta Neuropathologica Communications

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology

(2018) Mikael Marttinen et al.   NEUROBIOLOGY OF DISEASE

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and plasticity of meningeal lymphatic vessels

(2017) Salli Antila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Is sporadic Alzheimer′s disease a developmental disorder?

(2017) Thomas Arendt et al.   JOURNAL OF NEUROCHEMISTRY

FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques

(2017) Rajnish S. Dave et al.   Journal of Neuroimmune Pharmacology

Viruses and Multiple Sclerosis: From Mechanisms and Pathways to Translational Research Opportunities

(2017) Alexios-Fotios A. Mentis et al.   MOLECULAR NEUROBIOLOGY

Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load

(2017) K Goozee et al.   MOLECULAR PSYCHIATRY

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

(2017) K E Hopperton et al.   MOLECULAR PSYCHIATRY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

(2017) Neil I Bower et al.   NATURE NEUROSCIENCE

Vascular heterogeneity and specialization in development and disease

(2017) Michael Potente et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

(2017) Efthimios Dardiotis et al.   NEUROBIOLOGY OF AGING

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases

(2017) Nils C. Gassen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Factors Associated with Lymphosclerosis

(2017) Takumi Yamamoto et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Islet amyloid polypeptide: Another key molecule in Alzheimer’s pathogenesis?

(2017) Yun Zhang et al.   PROGRESS IN NEUROBIOLOGY

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

(2017) Hélène-Marie Lanoiselée et al.   PLOS MEDICINE

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

(2017) Jerome Robert et al.   eLife

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Mediterranean diet and cognitive health: Initial results from the Hellenic Longitudinal Investigation of Ageing and Diet

(2017) Costas A. Anastasiou et al.   PLoS One

Prominent Lymphatic Vessel Hyperplasia with Progressive Dysfunction and Distinct Immune Cell Infiltration in Lymphedema

(2016) Epameinondas Gousopoulos et al.   AMERICAN JOURNAL OF PATHOLOGY

Lymphatic System in Cardiovascular Medicine

(2016) Aleksanteri Aspelund et al.   CIRCULATION RESEARCH

Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases

(2016) Robert W. Mahley   CLINICAL CHEMISTRY

Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease

(2016) Niklas Mattsson et al.   EMBO Molecular Medicine

Integration of CD45-positive leukocytes into newly forming lymphatics of adult mice

(2016) K. Buttler et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment

(2016) Shiran Salomon-Zimri et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Epigenetics of dementia: understanding the disease as a transformation rather than a state

(2016) Bryan Maloney et al.   LANCET NEUROLOGY

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

(2016) Thiyagaragan M. Achariyar et al.   Molecular Neurodegeneration

Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway

(2016) V R Varma et al.   MOLECULAR PSYCHIATRY

Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer’s disease-related signaling

(2016) D A Bangasser et al.   MOLECULAR PSYCHIATRY

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies

(2016) Joshua T. Geiger et al.   NEUROBIOLOGY OF DISEASE

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

(2016) Antoine Louveau et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Epigenomic engineering for Down syndrome

(2016) A.F. Mentis   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation

(2016) Yinyuan Ding et al.   Science Signaling

Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation

(2016) Yinyuan Ding et al.   Science Signaling

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

(2016) Shorena Janelidze et al.   Annals of Clinical and Translational Neurology

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

(2015) Panos Roussos et al.   Alzheimers & Dementia

Neuropsychiatric Symptoms as Predictors of Progression to Severe Alzheimer’s Dementia and Death: The Cache County Dementia Progression Study

(2015) Matthew E. Peters et al.   AMERICAN JOURNAL OF PSYCHIATRY

Nonvenous Origin of Dermal Lymphatic Vasculature

(2015) I. Martinez-Corral et al.   CIRCULATION RESEARCH

Role of Apolipoprotein E in β-Amyloidogenesis

(2015) Yukiko Hori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The identification of cognitive subtypes in Alzheimer's disease dementia using latent class analysis

(2015) Nienke M E Scheltens et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Generalized lymphedema associated with neurologic signs (GLANS) syndrome: A new entity?

(2015) Marine Berton et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1

(2015) Ziran Wang et al.   MOLECULAR NEUROBIOLOGY

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease

(2015) J I Vélez et al.   MOLECULAR PSYCHIATRY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Cardiac lymphatics are heterogeneous in origin and respond to injury

(2015) Linda Klotz et al.   NATURE

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Stress, the Stress System and the Role of Glucocorticoids

(2015) Nicolas C. Nicolaides et al.   NEUROIMMUNOMODULATION

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes

(2015) Balthasar A. Heesters et al.   PLoS Pathogens

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

(2014) Catherine F. Slattery et al.   Alzheimers & Dementia

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome

(2014) Mariëlle Alders et al.   HUMAN GENETICS

Immune cell trafficking from the brain maintains CNS immune tolerance

(2014) Mohammad G. Mohammad et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphangiogenic factors, mechanisms, and applications

(2014) Wei Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel

(2014) Aleksanteri Aspelund et al.   JOURNAL OF CLINICAL INVESTIGATION

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease

(2014) Y Y Lim et al.   MOLECULAR PSYCHIATRY

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

(2014) Miguel Pappolla et al.   NEUROBIOLOGY OF DISEASE

Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease

(2014) Zuzana Šišková et al.   NEURON

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis

(2013) Theodora Psaltopoulou et al.   ANNALS OF NEUROLOGY

Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema

(2013) Kristiana Gordon et al.   CIRCULATION RESEARCH

Impact of Apolipoprotein E on Alzheimer’s Disease

(2013) Paul Hauser et al.   Current Alzheimer Research

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4, and the Risk of Late-Onset Alzheimer Disease in African Americans

(2013) Christiane Reitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Human housekeeping genes, revisited

(2013) Eli Eisenberg et al.   TRENDS IN GENETICS

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

(2013) Matthew R. Halliday et al.   JAMA Neurology

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

(2012) Nike Julia Krautler et al.   CELL

Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation

(2012) Amélie Sabine et al.   DEVELOPMENTAL CELL

Blood flow reprograms lymphatic vessels to blood vessels

(2012) Chiu-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy

(2012) Stavros J. Baloyannis et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Variant TREM2 as Risk Factor for Alzheimer's Disease

(2012) Harald Neumann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood A  clearance in a mouse model of  -amyloidosis

(2012) J. M. Castellano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOE  4 Status and Traumatic Brain Injury on the Gridiron or the Battlefield

(2012) S. Gandy et al.   Science Translational Medicine

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

(2012) Debby Tsuang et al.   JAMA Neurology

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

GJC2 Missense Mutations Cause Human Lymphedema

(2010) Robert E. Ferrell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

(2009) Hwee Ying Lim et al.   AMERICAN JOURNAL OF PATHOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Topographic study on nerve-associated lymphatic vessels in the murine craniofacial region by immunohistochemistry and electron microscopy

(2009) Masahide Furukawa et al.   BIOMEDICAL RESEARCH-TOKYO

Lymphatic development

(2009) Matthew G. Butler et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Amyloid- (1-42), Total Tau, and Phosphorylated Tau as Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease

(2009) C. Mulder et al.   CLINICAL CHEMISTRY

Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis

(2009) Eleni Bazigou et al.   DEVELOPMENTAL CELL

Novel missense mutations in theFOXC2gene alter transcriptional activity

(2009) M.A.M. van Steensel et al.   HUMAN MUTATION

Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans

(2009) Marielle Alders et al.   NATURE GENETICS

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

Gene expression changes in the course of normal brain aging are sexually dimorphic

(2008) N. C. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING