The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
出版年份 2019 全文链接
标题
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
作者
关键词
-
出版物
Science Translational Medicine
Volume 11, Issue 505, Pages eaau2291
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2019-08-15
DOI
10.1126/scitranslmed.aau2291
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?
- (2018) Yuetiva Deming et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders
- (2018) Susana Carmona et al. LANCET NEUROLOGY
- Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models
- (2018) C.Y. Daniel Lee et al. NEURON
- Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure
- (2018) Zeran Li et al. Genome Medicine
- Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Diagnostic Performance in a Homogeneous Mono-Center Population
- (2018) Per Johansson et al. JOURNAL OF ALZHEIMERS DISEASE
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- MS4A4A: a novel cell surface marker for M2 macrophages and plasma cells
- (2017) Ratna Sanyal et al. IMMUNOLOGY AND CELL BIOLOGY
- MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data
- (2017) Olena O Yavorska et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Soluble TREM2 induces inflammatory responses and enhances microglial survival
- (2017) Li Zhong et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TREM2-Ligand Interactions in Health and Disease
- (2017) Daniel L. Kober et al. JOURNAL OF MOLECULAR BIOLOGY
- Glial contributions to neurodegeneration in tauopathies
- (2017) Cheryl E. G. Leyns et al. Molecular Neurodegeneration
- TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
- (2017) Shane M. Bemiller et al. Molecular Neurodegeneration
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
- (2017) Kuan-lin Huang et al. NATURE NEUROSCIENCE
- Elucidating the Role of TREM2 in Alzheimer’s Disease
- (2017) Jason D. Ulrich et al. NEURON
- TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
- (2017) Cheryl E. G. Leyns et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Connecting genetic risk to disease end points through the human blood plasma proteome
- (2017) Karsten Suhre et al. Nature Communications
- Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis
- (2017) Bruno A. Benitez et al. Scientific Reports
- Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
- (2017) Lasse Folkersen et al. PLoS Genetics
- Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
- (2016) Laura Piccio et al. ACTA NEUROPATHOLOGICA
- Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?
- (2016) Ting-Ting Chang et al. Cardiovascular Diabetology
- sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
- (2016) Marc Suárez‐Calvet et al. EMBO Molecular Medicine
- Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
- (2016) Daniel I Swerdlow et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
- (2016) Amanda Heslegrave et al. Molecular Neurodegeneration
- Near-optimal probabilistic RNA-seq quantification
- (2016) Nicolas L Bray et al. NATURE BIOTECHNOLOGY
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
- (2016) Ye Zhang et al. NEURON
- Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury
- (2016) M. Suarez-Calvet et al. Science Translational Medicine
- Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease
- (2016) Kristi Henjum et al. Alzheimers Research & Therapy
- Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases
- (2016) Mariet Allen et al. Scientific Data
- Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
- (2016) Yuetiva Deming et al. Scientific Reports
- TREM2 regulates microglial cell activation in response to demyelination in vivo
- (2015) Claudia Cantoni et al. ACTA NEUROPATHOLOGICA
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling
- (2015) Glenn Cruse et al. MOLECULAR BIOLOGY OF THE CELL
- TREM2 in CNS homeostasis and neurodegenerative disease
- (2015) Meghan M. Painter et al. Molecular Neurodegeneration
- TREM2 is associated with increased risk for Alzheimer’s disease in African Americans
- (2015) Sheng Chih Jin et al. Molecular Neurodegeneration
- The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
- (2015) et al. SCIENCE
- Second-generation PLINK: rising to the challenge of larger and richer datasets
- (2015) Christopher C Chang et al. GigaScience
- Coding variants in TREM2 increase risk for Alzheimer's disease
- (2014) Sheng Chih Jin et al. HUMAN MOLECULAR GENETICS
- An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
- (2014) Y. Zhang et al. JOURNAL OF NEUROSCIENCE
- Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
- (2014) Jason D Ulrich et al. Molecular Neurodegeneration
- Frontobasal gray matter loss is associated with the TREM2 p.R47H variant
- (2014) Elkin O. Luis et al. NEUROBIOLOGY OF AGING
- Powerful detection of osteoarthritis susceptibility loci by comprehensive examination of clinically important endophenotypes
- (2014) K. Panoutsopoulou et al. OSTEOARTHRITIS AND CARTILAGE
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
- (2014) G. Kleinberger et al. Science Translational Medicine
- Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
- (2014) Olivier Delaneau et al. Nature Communications
- Apolipoprotein E Genotype and the Diagnostic Accuracy of Cerebrospinal Fluid Biomarkers for Alzheimer Disease
- (2014) Ronald Lautner et al. JAMA Psychiatry
- TREM2 and the neuroimmunology of Alzheimer's disease
- (2013) Suzanne E. Hickman et al. BIOCHEMICAL PHARMACOLOGY
- Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage
- (2013) Patrick Wunderlich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Systematic identification of trans eQTLs as putative drivers of known disease associations
- (2013) Harm-Jan Westra et al. NATURE GENETICS
- A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family
- (2013) Rita Guerreiro et al. NEUROBIOLOGY OF AGING
- TREM2 is associated with the risk of Alzheimer's disease in Spanish population
- (2013) Bruno A. Benitez et al. NEUROBIOLOGY OF AGING
- GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease
- (2013) Carlos Cruchaga et al. NEURON
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Annotation of functional variation in personal genomes using RegulomeDB
- (2012) A. P. Boyle et al. GENOME RESEARCH
- Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease
- (2012) Carlos Cruchaga et al. HUMAN MOLECULAR GENETICS
- Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
- (2012) Bryan Howie et al. NATURE GENETICS
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies
- (2011) Daniah Trabzuni et al. JOURNAL OF NEUROCHEMISTRY
- HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
- (2011) L. D. Ward et al. NUCLEIC ACIDS RESEARCH
- LocusZoom: regional visualization of genome-wide association scan results
- (2010) R. J. Pruim et al. BIOINFORMATICS
- METAL: fast and efficient meta-analysis of genomewide association scans
- (2010) C. J. Willer et al. BIOINFORMATICS
- Identification of Quantitative Trait Loci Underlying Proteome Variation in Human Lymphoblastoid Cells
- (2010) Nikhil Garge et al. MOLECULAR & CELLULAR PROTEOMICS
- ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
- (2010) K. Wang et al. NUCLEIC ACIDS RESEARCH
- SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease
- (2010) Carlos Cruchaga et al. PLoS Genetics
- Variants in TF and HFE Explain ∼40% of Genetic Variation in Serum-Transferrin Levels
- (2008) Beben Benyamin et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
- (2008) Laura Piccio et al. BRAIN
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search