The anatomy and immunology of vasculature in the central nervous system

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity

(2019) Rejane Rua et al.   NATURE IMMUNOLOGY

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

(2018) Matthew V. Russo et al.   NATURE IMMUNOLOGY

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advances in Meningeal Immunity

(2018) Rejane Rua et al.   TRENDS IN MOLECULAR MEDICINE

Leukaemia hijacks a neural mechanism to invade the central nervous system

(2018) Hisayuki Yao et al.   NATURE

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

(2018) Fanny Herisson et al.   NATURE NEUROSCIENCE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Molecular characterization of perivascular drainage pathways in the murine brain

(2017) Melanie-Jane Hannocks et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

(2017) Sam Horng et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial

(2017) Jacob Elkins et al.   LANCET NEUROLOGY

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

(2017) Yasir N. Jassam et al.   NEURON

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke

(2016) Melissa A. Lopes Pinheiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Central Nervous System Stromal Cells Control Local CD8 + T Cell Responses during Virus-Induced Neuroinflammation

(2016) Jovana Cupovic et al.   IMMUNITY

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

(2016) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Choroid Plexus in Healthy and Diseased Brain

(2016) Charanjit Kaur et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

(2016) Nanhong Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology

(2016) Aleksandra Deczkowska et al.   TRENDS IN IMMUNOLOGY

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

(2016) Phillip A. Swanson et al.   PLoS Pathogens

Matrix metalloproteinases as therapeutic targets for stroke

(2015) Yi Yang et al.   BRAIN RESEARCH

Heterogeneous vascular permeability and alternative diffusion barrier in sensory circumventricular organs of adult mouse brain

(2015) Shoko Morita et al.   CELL AND TISSUE RESEARCH

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

(2015) Silvia Tietz et al.   JOURNAL OF CELL BIOLOGY

Bacterial induction of Snail1 contributes to blood-brain barrier disruption

(2015) Brandon J. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity

(2015) Jonathan J Miner et al.   NATURE MEDICINE

Brain Swelling and Death in Children with Cerebral Malaria

(2015) Karl B. Seydel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

(2015) Helen M. Lazear et al.   Science Translational Medicine

Immune Surveillance of the CNS following Infection and Injury

(2015) Matthew V. Russo et al.   TRENDS IN IMMUNOLOGY

The choroid plexus—a multi-role player during infectious diseases of the CNS

(2015) Christian Schwerk et al.   Frontiers in Cellular Neuroscience

Normal pio-dural arterial connections

(2015) Pervinder Bhogal et al.   INTERVENTIONAL NEURORADIOLOGY

Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration

(2015) Jian Song et al.   Cell Reports

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

(2015) Natalya Korogod et al.   eLife

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Neutrophil recruitment to the brain in mouse and human ischemic stroke

(2014) Isabel Perez-de-Puig et al.   ACTA NEUROPATHOLOGICA

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals

(2014) B. P. Daniels et al.   mBio

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

CNS-specific T cells shape brain function via the choroid plexus

(2013) Kuti Baruch et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-Like Receptors: Sensor Molecules for Detecting Damage to the Nervous System

(2013) Hyunkyoung Lee et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria

(2013) Shanshan W. Howland et al.   EMBO Molecular Medicine

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

(2013) Fanny Langlet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice

(2013) A Radjavi et al.   MOLECULAR PSYCHIATRY

Transcranial amelioration of inflammation and cell death after brain injury

(2013) Theodore L. Roth et al.   NATURE

A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity

(2013) Dmitri Lodygin et al.   NATURE MEDICINE

Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS

(2013) Hongxia Duan et al.   Scientific Reports

Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease

(2013) Roxana Carare et al.   Acta Neuropathologica Communications

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

(2012) Michael Gliem et al.   ANNALS OF NEUROLOGY

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

(2012) Catherine Larochelle et al.   BRAIN

Neutrophil-active chemokines in in vivo imaging of neutrophil trafficking

(2012) Maria-Jesus Sanz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS

(2012) Ken Flanagan et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

(2011) Lillian Cruz-Orengo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

(2011) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anatomy and Pathology of the Cranial Emissary Veins

(2011) Martin M. Mortazavi et al.   NEUROSURGERY

Comparison of Immortalized bEnd5 and Primary Mouse Brain Microvascular Endothelial Cells as in vitro Blood–Brain Barrier Models for the Study of T Cell Extravasation

(2010) Oliver Steiner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Immune surveillance of the normal human CNS takes place in dependence of the locoregional blood-brain barrier configuration and is mainly performed by CD3+/CD8+ lymphocytes

(2010) Christian Loeffler et al.   NEUROPATHOLOGY

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1

(2009) A. Woodfin et al.   BLOOD

Brain-Endocrine Interactions: A Microvascular Route in the Mediobasal Hypothalamus

(2009) Philippe Ciofi et al.   ENDOCRINOLOGY

Lymphocytic Choriomeningitis Virus-Induced Mortality in Mice Is Triggered by Edema and Brain Herniation

(2009) C. M. Matullo et al.   JOURNAL OF VIROLOGY

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

(2009) Silvia Buonamici et al.   NATURE

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis

(2008) Erin E. McCandless et al.   AMERICAN JOURNAL OF PATHOLOGY

Models of multiple sclerosis: new insights into pathophysiology and repair

(2008) Hans Lassmann   CURRENT OPINION IN NEUROLOGY

An Analysis of Regional Microvascular Loss and Recovery following Two Grades of Fluid Percussion Trauma: A Role for Hypoxia-Inducible Factors in Traumatic Brain Injury

(2008) Eugene Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Perivascular Spaces and the Two Steps to Neuroinflammation

(2008) Trevor Owens et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

(2008) Jiyun V. Kim et al.   NATURE

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Experimental models, neurovascular mechanisms and translational issues in stroke research

(2007) E H Lo   BRITISH JOURNAL OF PHARMACOLOGY