Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection

(2019) Eric M. Velazquez et al.   Nature Microbiology

A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)

(2019) Christopher Geven et al.   BMJ Open

Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients

(2019) Dorothy M. Wade et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immune Checkpoint Inhibition in Sepsis

(2019) Richard S. Hotchkiss et al.   CRITICAL CARE MEDICINE

Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle

(2019) Sebastien Preau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Glucose control in the ICU

(2019) Jan Gunst et al.   Current Opinion in Anesthesiology

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

(2019) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival

(2019) Derek B. Danahy et al.   JOURNAL OF IMMUNOLOGY

Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes

(2019) Scott C. Brakenridge et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Influences of stress hormones on microbial infections

(2019) Emmanuel Konadu Sarkodie et al.   MICROBIAL PATHOGENESIS

Role of ghrelin on growth hormone/insulin-like growth factor-1 axis during endotoxemia

(2019) Felipe Faim et al.   GROWTH HORMONE & IGF RESEARCH

Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab

(2019) Richard S. Hotchkiss et al.   INTENSIVE CARE MEDICINE

Sepsis hysteria: excess hype and unrealistic expectations

(2019) Mervyn Singer et al.   LANCET

Ghrelin alterations during experimental and human sepsis

(2019) I. Nikitopoulou et al.   CYTOKINE

Do critical care patients hibernate? Theoretical support for less is more

(2019) Giacomo Stanzani et al.   INTENSIVE CARE MEDICINE

Current gaps in sepsis immunology: new opportunities for translational research

(2019) Ignacio Rubio et al.   LANCET INFECTIOUS DISEASES

Validation of a Host Response Assay, Septicyte™ LAB, for Discriminating Sepsis from SIRS in the ICU

(2018) Russell R Miller III et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia

(2018) Birgitt Gutbier et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular and Functional Neuroscience in Immunity

(2018) Valentin A. Pavlov et al.   Annual Review of Immunology

Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects

(2018) Christopher Geven et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis

(2018) Joel R. Wilmore et al.   Cell Host & Microbe

Endocrine and Metabolic Alterations in Sepsis and Implications for Treatment

(2018) Catherine Ingels et al.   CRITICAL CARE CLINICS

MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock

(2018) Francisco Vasques-Nóvoa et al.   CRITICAL CARE MEDICINE

Molecular Regulation of Acute Tie2 Suppression in Sepsis

(2018) Kristina Thamm et al.   CRITICAL CARE MEDICINE

Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis

(2018) Suresh K. Angurana et al.   CRITICAL CARE MEDICINE

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters

(2018) Timothy E. Sweeney et al.   CRITICAL CARE MEDICINE

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

(2018) Tobias Welte et al.   INTENSIVE CARE MEDICINE

Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study

(2018) Andrew Conway Morris et al.   INTENSIVE CARE MEDICINE

Pathogen colonization of the gastrointestinal microbiome at intensive care unit admission and risk for subsequent death or infection

(2018) Daniel E. Freedberg et al.   INTENSIVE CARE MEDICINE

Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study

(2018) Marianna Parlato et al.   INTENSIVE CARE MEDICINE

Enhancing Recovery From Sepsis

(2018) Hallie C. Prescott et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia

(2018) Ho Pan Sham et al.   JOURNAL OF IMMUNOLOGY

Interleukin 38 Protects Against Lethal Sepsis

(2018) Fang Xu et al.   JOURNAL OF INFECTIOUS DISEASES

Compartment diversity in innate immune reprogramming

(2018) Orhan Rasid et al.   MICROBES AND INFECTION

Long-Term Cognitive Outcomes After Sepsis: a Translational Systematic Review

(2018) Tatiana Barichello et al.   MOLECULAR NEUROBIOLOGY

Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis

(2018) Yue Zhou et al.   MOLECULAR THERAPY

Current understanding of the human microbiome

(2018) Jack A Gilbert et al.   NATURE MEDICINE

Mechanisms and treatment of organ failure in sepsis

(2018) Christophe Lelubre et al.   Nature Reviews Nephrology

Neuroimaging Findings in Sepsis-Induced Brain Dysfunction: Association with Clinical and Laboratory Findings

(2018) Günseli Orhun et al.   Neurocritical Care

Pro-inflammatory activation of microglia in the brain of patients with sepsis

(2018) T. Zrzavy et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Electroacupuncture prevents cognitive impairment induced by lipopolysaccharide via inhibition of oxidative stress and neuroinflammation

(2018) Yao-Guo Han et al.   NEUROSCIENCE LETTERS

Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve

(2018) Suyan Li et al.   NEUROSCIENCE LETTERS

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels

(2018) Elisa Balboa et al.   SHOCK

Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis

(2018) Julie A. Stortz et al.   SHOCK

Hemophagocytic Lymphohistiocytosis

(2018) Gunnar Lachmann et al.   SHOCK

Exotoxins and endotoxins: Inducers of inflammatory cytokines

(2018) Jean-Marc Cavaillon   TOXICON

A community approach to mortality prediction in sepsis via gene expression analysis

(2018) Timothy E. Sweeney et al.   Nature Communications

Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis

(2018) Ryota Fuke et al.   BMJ Open

Electroacupuncture Improves Intestinal Dysfunction in Septic Patients: A Randomised Controlled Trial

(2018) Jian-biao Meng et al.   Biomed Research International

Endothelial Activation: The Ang/Tie Axis in Sepsis

(2018) Aleksandra Leligdowicz et al.   Frontiers in Immunology

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

(2018) Hiroyuki Horiguchi et al.   Frontiers in Immunology

Deterioration of Organ Function As a Hallmark in Sepsis: The Cellular Perspective

(2018) Michael Bauer et al.   Frontiers in Immunology

Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients

(2018) Ali Danesh et al.   Frontiers in Immunology

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Arguing for Adaptive Clinical Trials in Sepsis

(2018) Victor B. Talisa et al.   Frontiers in Immunology

Human skin commensals augment Staphylococcus aureus pathogenesis

(2018) Emma Boldock et al.   Nature Microbiology

Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay

(2018) Felix Ellett et al.   Nature Biomedical Engineering

The role of epigenetic alterations involved in sepsis: An overview

(2018) Fatima Ismail Hassan et al.   CURRENT PHARMACEUTICAL DESIGN

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss)

(2018) Marcin F. Osuchowski et al.   SHOCK

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial

(2018) Carolyn S Calfee et al.   Lancet Respiratory Medicine

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial

(2018) David B Antcliffe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial

(2018) Ewan C. Goligher et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level

(2018) R. Phillip Dellinger et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Extracorporeal cytokine adsorption in septic shock: A proof of concept randomized, controlled pilot study

(2018) Fatime Hawchar et al.   JOURNAL OF CRITICAL CARE

Immunosuppression is Inappropriately Qualifying the Immune Status of Septic and SIRS Patients

(2018) Jean-Marc Cavaillon et al.   SHOCK

Simultaneous targeting of CD14 and factor XIa by a fusion protein consisting of an anti-CD14 antibody and the modified second domain of bikunin improves survival in rabbit sepsis models

(2017) Masaki Nakamura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Potentially modifiable factors contributing to sepsis-associated encephalopathy

(2017) Romain Sonneville et al.   INTENSIVE CARE MEDICINE

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014

(2017) Chanu Rhee et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cellular and extracellular miRNAs are blood-compartment-specific diagnostic targets in sepsis

(2017) Marlene Reithmair et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased healthcare facility use in veterans surviving sepsis hospitalization

(2017) Kimberley M. DeMerle et al.   JOURNAL OF CRITICAL CARE

Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response

(2017) Farina Borken et al.   JOURNAL OF IMMUNOLOGY

Hospital-related cost of sepsis: A systematic review

(2017) Habibollah Arefian et al.   JOURNAL OF INFECTION

Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice

(2017) Melissa B. McPeak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Long-term risk of seizures in adult survivors of sepsis

(2017) Michael E. Reznik et al.   NEUROLOGY

Recognizing Sepsis as a Global Health Priority — A WHO Resolution

(2017) Konrad Reinhart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness

(2017) Neil E. Hill et al.   PLoS One

Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model ofEscherichia colisepsis

(2017) Ravi Shankar Keshari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restorative Mechanisms Regulating Protein Balance in Skeletal Muscle During Recovery From Sepsis

(2017) Kristen T. Crowell et al.   SHOCK

Sphingosine-1-Phosphate

(2017) Martin S. Winkler et al.   SHOCK

Blocking Liver Autophagy Accelerates Apoptosis and Mitochondrial Injury in Hepatocytes and Reduces Time to Mortality in a Murine Sepsis Model

(2017) Takehiko Oami et al.   SHOCK

Coagulation and sepsis

(2017) Marcel Levi et al.   THROMBOSIS RESEARCH

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

(2017) Julie Rayes et al.   Nature Communications

The microbiota protects against respiratory infection via GM-CSF signaling

(2017) Rebecca L. Brown et al.   Nature Communications

A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification

(2017) U. Hassan et al.   Nature Communications

The gut microbiota as a modulator of innate immunity during melioidosis

(2017) Jacqueline M. Lankelma et al.   PLoS Neglected Tropical Diseases

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

(2017) Brendon P Scicluna et al.   Lancet Respiratory Medicine

Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat

(2017) Stephen J. Kuperberg et al.   Frontiers in Immunology

Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice

(2017) Jérome Morel et al.   Scientific Reports

Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes

(2017) Natalie E. Stevens et al.   Scientific Reports

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

(2016) T. A. M. Claushuis et al.   BLOOD

Neuroanatomy and Physiology of Brain Dysfunction in Sepsis

(2016) Aurelien Mazeraud et al.   CLINICS IN CHEST MEDICINE

The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness

(2016) Nathan J. Klingensmith et al.   CRITICAL CARE CLINICS

Use of Biotelemetry to Define Physiology-Based Deterioration Thresholds in a Murine Cecal Ligation and Puncture Model of Sepsis

(2016) Anthony J. Lewis et al.   CRITICAL CARE MEDICINE

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

(2016) Bita Shakoory et al.   CRITICAL CARE MEDICINE

Septic encephalopathy and septic encephalitis‬‬

(2016) Simone C. Tauber et al.   Expert Review of Anti-Infective Therapy

The immunoprotective activity of interleukin-33 in mouse model of cecal ligation and puncture-induced sepsis

(2016) Shu Li et al.   IMMUNOLOGY LETTERS

Comparison of sepsis rats induced by caecal ligation puncture or Staphylococcus aureus using a LC-QTOF-MS metabolomics approach

(2016) Zhang Lin et al.   INFECTION GENETICS AND EVOLUTION

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

(2016) Kim Timmermans et al.   INTENSIVE CARE MEDICINE

Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum

(2016) Davide Tommaso Andreis et al.   INTENSIVE CARE MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evaluation of the FilmArray Blood Culture Identification Panel: Results of a Multicenter Controlled Trial

(2016) Hossein Salimnia et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis

(2016) Javier Cabrera-Perez et al.   JOURNAL OF IMMUNOLOGY

Defining immunological dysfunction in sepsis: A requisite tool for precision medicine

(2016) Jesús F. Bermejo-Martin et al.   JOURNAL OF INFECTION

Treatment of endotoxaemia and septicaemia in the equine patient

(2016) A. H. Werners   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

The Early Expression of HLA-DR and CD64 Myeloid Markers Is Specifically Compartmentalized in the Blood and Lungs of Patients with Septic Shock

(2016) Tomasz Skirecki et al.   MEDIATORS OF INFLAMMATION

Microbiome-wide association studies link dynamic microbial consortia to disease

(2016) Jack A. Gilbert et al.   NATURE

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit

(2016) Stéphane Gaudry et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study

(2016) Rachel D. Savage et al.   PLoS One

Mechanisms of Intestinal Barrier Dysfunction in Sepsis

(2016) Benyam P. Yoseph et al.   SHOCK

LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways

(2016) Heng Zeng et al.   Scientific Reports

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Disruption of the microbiota across multiple body sites in critically ill children

(2016) Matthew B. Rogers et al.   Microbiome

The Role of ACTH and Corticosteroids for Sepsis and Septic Shock: An Update

(2016) Djillali Annane   Frontiers in Endocrinology

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome

(2016) Robert P. Dickson et al.   Nature Microbiology

Moving From Disease-Centered to Patient Goals–Directed Care for Patients With Multiple Chronic Conditions

(2016) Mary E. Tinetti et al.   JAMA Cardiology

NK cells promote neutrophil recruitment in the brain during sepsis-induced neuroinflammation

(2016) Hao He et al.   Scientific Reports

Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain–immune interface

(2016) Sanae Hasegawa-Ishii et al.   Scientific Reports

Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis

(2015) Parjam S. Zolfaghari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intraalveolar Catecholamines and the Human Lung Microbiome

(2015) Robert P. Dickson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hospitalization Type and Subsequent Severe Sepsis

(2015) Hallie C. Prescott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

(2015) Hector R. Wong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Brain Tissue Oxygenation in Patients with Septic Shock: a Feasibility Study

(2015) Michael Wood et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections*

(2015) Jean-Louis Vincent et al.   CRITICAL CARE MEDICINE

Stress Disorders Following Prolonged Critical Illness in Survivors of Severe Sepsis

(2015) Gloria-Beatrice Wintermann et al.   CRITICAL CARE MEDICINE

Dysregulation in microRNA expression in peripheral blood mononuclear cells of sepsis patients is associated with immunopathology

(2015) Juhua Zhou et al.   CYTOKINE

Metagenomic Analysis Reveals Dynamic Changes of Whole Gut Microbiota in the Acute Phase of Intensive Care Unit Patients

(2015) Masahiro Ojima et al.   DIGESTIVE DISEASES AND SCIENCES

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

CD39 improves survival in microbial sepsis by attenuating systemic inflammation

(2015) Balázs Csóka et al.   FASEB JOURNAL

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Readmission Diagnoses After Hospitalization for Severe Sepsis and Other Acute Medical Conditions

(2015) Hallie C. Prescott et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged

(2015) Dina C. Nacionales et al.   JOURNAL OF IMMUNOLOGY

Endothelial barrier dysfunction in septic shock

(2015) S. M. Opal et al.   JOURNAL OF INTERNAL MEDICINE

The future of murine sepsis and trauma research models

(2015) Philip A. Efron et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil extracellular traps in patients with sepsis

(2015) Masamitsu Hashiba et al.   JOURNAL OF SURGICAL RESEARCH

The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill

(2015) O. Friedrich et al.   PHYSIOLOGICAL REVIEWS

Profound Endothelial Damage Predicts Impending Organ Failure and Death in Sepsis

(2015) Pär Johansson et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Metabolomic Analyses of Brain Tissue in Sepsis Induced by Cecal Ligation Reveal Specific Redox Alterations—Protective Effects of the Oxygen Radical Scavenger Edaravone

(2015) Naomi Hara et al.   SHOCK

Sepsis Attenuates the Anabolic Response to Skeletal Muscle Contraction

(2015) Jennifer L. Steiner et al.   SHOCK

Impaired Heart Rate Regulation and Depression of Cardiac Chronotropic and Dromotropic Function in Polymicrobial Sepsis

(2015) Donald B. Hoover et al.   SHOCK

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

(2015) P. Rocheteau et al.   Nature Communications

Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model

(2015) Tomasz Skirecki et al.   Stem Cell Research & Therapy

Cognitive decline after sepsis

(2015) Djillali Annane et al.   Lancet Respiratory Medicine

A Novel Host-Proteome Signature for Distinguishing between Acute Bacterial and Viral Infections

(2015) Kfir Oved et al.   PLoS One

Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock

(2014) Tom Vanden Berghe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Minocycline But Not Tigecycline Is Neuroprotective and Reduces the Neuroinflammatory Response Induced by the Superimposition of Sepsis Upon Traumatic Brain Injury*

(2014) Chiara Adembri et al.   CRITICAL CARE MEDICINE

Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2

(2014) Ivan Tancevski et al.   EMBO Molecular Medicine

HMGB1 as a therapeutic target for sepsis: it's all in the timing!

(2014) Lori F Gentile et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness

(2014) Tobias Wollersheim et al.   INTENSIVE CARE MEDICINE

Accuracy of LightCycler® SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis

(2014) Paul Dark et al.   INTENSIVE CARE MEDICINE

Longitudinal Assessment of Adrenal Function in the Early and Prolonged Phases of Critical Illness in Septic Patients: Relations to Cytokine Levels and Outcome

(2014) Dimitra Argyro Vassiliadi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CD24-Triggered Caspase-Dependent Apoptosis via Mitochondrial Membrane Depolarization and Reactive Oxygen Species Production of Human Neutrophils Is Impaired in Sepsis

(2014) M. Parlato et al.   JOURNAL OF IMMUNOLOGY

Reflex control of inflammation by sympathetic nerves, not the vagus

(2014) D. Martelli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Age-Associated Increase in Cytokine Production During Systemic Inflammation—II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue

(2014) Marlene E. Starr et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dopamine mediates vagal modulation of the immune system by electroacupuncture

(2014) Rafael Torres-Rosas et al.   NATURE MEDICINE

Host Responses to Sepsis Vary in Different Low-Lethality Murine Models

(2014) Lori F. Gentile et al.   PLoS One

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Membership and Behavior of Ultra-Low-Diversity Pathogen Communities Present in the Gut of Humans during Prolonged Critical Illness

(2014) A. Zaborin et al.   mBio

Symptoms of Depression in Survivors of Severe Sepsis: A Prospective Cohort Study of Older Americans

(2013) Dimitry S. Davydow et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Identification and Description of a Novel Murine Model for Polytrauma and Shock

(2013) Lori F. Gentile et al.   CRITICAL CARE MEDICINE

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis

(2013) Jesmond Dalli et al.   EMBO Molecular Medicine

CD137 Expressed on Neutrophils Plays Dual Roles in Antibacterial Responses against Gram-Positive and Gram-Negative Bacterial Infections

(2013) Quang-Tam Nguyen et al.   INFECTION AND IMMUNITY

Comparative Analysis of Monocyte Subsets in the Pig

(2013) L. Fairbairn et al.   JOURNAL OF IMMUNOLOGY

Sustained and Incomplete Recovery of Naive CD8+ T Cell Precursors after Sepsis Contributes to Impaired CD8+ T Cell Responses to Infection

(2013) S. A. Condotta et al.   JOURNAL OF IMMUNOLOGY

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superantigens Are Critical for Staphylococcus aureus Infective Endocarditis, Sepsis, and Acute Kidney Injury

(2013) W. Salgado-Pabon et al.   mBio

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway

(2013) Binggang Xiang et al.   Nature Communications

The role of mitochondrial dysfunction in sepsis-induced multi-organ failure

(2013) Mervyn Singer   Virulence

Disruption of Platelet-derived Chemokine Heteromers Prevents Neutrophil Extravasation in Acute Lung Injury

(2012) Jochen Grommes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intensive Care Unit–acquired Weakness

(2012) Jane Batt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*

(2012) François Philippart et al.   CRITICAL CARE MEDICINE

Cecal Ligation and Puncture-Induced Murine Sepsis Does Not Cause Lung Injury*

(2012) Kendra N. Iskander et al.   CRITICAL CARE MEDICINE

Platelet mRNA

(2012) Jesse W. Rowley et al.   CURRENT OPINION IN HEMATOLOGY

Absolute counts of peripheral blood leukocyte subpopulations in intraabdominal sepsis and pneumonia-derived sepsis: a pilot study

(2012) Grazyna Anna Hoser et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Unstressing intemperate models: how cold stress undermines mouse modeling

(2012) Christopher L. Karp   JOURNAL OF EXPERIMENTAL MEDICINE

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

Unknown

(2012) Sangeeta Chavan et al.   MOLECULAR MEDICINE

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

DNAemia Detection by Multiplex PCR and Biomarkers for Infection in Systemic Inflammatory Response Syndrome Patients

(2012) Catherine Fitting et al.   PLoS One

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

The Endogenous Bacteria Alter Gut Epithelial Apoptosis and Decrease Mortality Following Pseudomonas aeruginosa Pneumonia

(2012) Amy C. Fox et al.   SHOCK

Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes

(2011) Ronan Kapetanovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Improving long-term outcomes after discharge from intensive care unit

(2011) Dale M. Needham et al.   CRITICAL CARE MEDICINE

Tumor Necrosis Factor Inhibits Glucocorticoid Receptor Function in Mice

(2011) Tom Van Bogaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscle weakness in septic patients requiring mechanical ventilation: Protective effect of transcutaneous neuromuscular electrical stimulation

(2011) Pablo O. Rodriguez et al.   JOURNAL OF CRITICAL CARE

Trauma Hemorrhagic Shock-Induced Lung Injury Involves a Gut-Lymph-Induced TLR4 Pathway in Mice

(2011) Diego C. Reino et al.   PLoS One

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth

(2010) K. A. Cavassani et al.   BLOOD

Effect of transcutaneous electrical muscle stimulation on muscle volume in patients with septic shock*

(2010) Jesper B. Poulsen et al.   CRITICAL CARE MEDICINE

Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: a systematic review

(2010) Anna G Angelousi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Functional Comparison of Innate Immune Signaling Pathways in Primates

(2010) Luis B. Barreiro et al.   PLoS Genetics

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of pediatric septic shock subclasses based on genome-wide expression profiling

(2009) Hector R Wong et al.   BMC Medicine

Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality*

(2009) Tarek Sharshar et al.   CRITICAL CARE MEDICINE

Stratification is the key: Inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis*

(2009) Marcin F. Osuchowski et al.   CRITICAL CARE MEDICINE

Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: A randomized controlled trial*

(2009) Didier Payen et al.   CRITICAL CARE MEDICINE

Resilience to Bacterial Infection: Difference between Species Could Be Due to Proteins in Serum

(2009) H. Shaw Warren et al.   JOURNAL OF INFECTIOUS DISEASES

Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

(2009) William D Schweickert et al.   LANCET

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

(2008) Alex Dyson et al.   CRITICAL CARE MEDICINE

Circulating levels of GH predict mortality and complement prognostic scores in critically ill medical patients

(2008) Philipp Schuetz et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Impact of antibiotics on the gut microbiota of critically ill patients

(2008) G. Iapichino et al.   JOURNAL OF MEDICAL MICROBIOLOGY